DBA/2J

Strain details
Nomenclature	DBA/2JOzarc
Common name	DBA/2J
Synonyms	DB2, D2J, D2, DBA, DBA/2
Strain	Inbred
Coat colour	Dilute brown (a/a Tyrp1^b/Tyrp1^b Myo5a^d/Myo5a^d)
Species	Mouse
JAX stock number	000671
Location	Area Oz2

Strain descriptions

MHC haplotype: H2K^d
Complement factor: C5 deficient
DBA/2J strain is distinct from the C57BL/6J strain and exhibits unique characteristics.
This strain has high incidence of sterility.
DBA/2J mice show a low susceptibility to developing atherosclerotic aortic lesions following 14 weeks on an atherogenic diet.
This strain is homozygous for Cdh23^ahl, the age-related hearing loss 1 mutation, which on this background results in progressive hearing loss that is already severe by three months of age.
They exhibit eye abnormalities similar to human glaucoma, including iris pigment dispersion, iris atrophy, and elevated intraocular pressure.
DBA/2J mice are susceptible to audiogenic seizures in their early age, but this decreases as they reach adulthood.
They also exhibit calcareous pericarditis and calcified lesions in various organs.
DBA/2J mice show affinity for methamphetamine, but intolerance to alcohol and morphine. Notably, they lack surface expression of CD94/NKG2A receptors on NK cells, which are involved in self-tolerance and recognition of target cells.

The DBA inbred strain is the oldest of all inbred strains of mice. Dr. CC Little began inbreeding in 1909 from a mouse colony segregating for coat color. During 1929 and 1930 crosses were made among substrains, and several new substrains were established including DBA/1 and DBA/2. DBA/1 and DBA/2 differ at a large number of loci (including the MHC H2haplotype) which is most likely results from residual heterozygosity in the strain when the substrains were separated.
DBA/2J strain was transferred from ARC to Ozgene ARC in 2023.

DBA/2J is a widely used inbred strain that is valuable in many research areas, including cardiovascular biology, neurobiology, and sensorineural research.

Past ARC and transfer reports:

Current Ozgene ARC reports (from 01-Jun-2023)

These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: JAX General Terms and Conditions.
JAX mice are the gold standard for animal model research.
Ozgene ARC terms and Conditions

Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors