Papers

Please browse here to find research papers published by our clients utilising Ozgene mice.

2017

1. Endogenous inspired biomineral-installed hyaluronan nanoparticles as pH-responsive carrier of methotrexate for rheumatoid arthritis. (KO conditional)
MM Alam; HS Han; S Sung; JH Kang; KH Sa; H Al Faruque; J Hong; EJ Nam; IS Kim; JH Park; YM Kang
J Control Release., 2017 Mar 11;252:62-72. doi: 10.1016/j.jconrel.2017.03.012. [Epub ahead of print]
Kyungpook National University Hospital 130 Dongdeok-ro, Junggu, Daegu 41944, Republic of Korea. Sungkyunkwan University, Suwon 440-746, Republic of Korea. Kyungpook National University School of Medicine, Daegu 700-422, Republic of Korea. Sungkyunkwan University, Suwon 440-746, Republic of Korea.
2. The Inflammatory Bowel Disease-Associated Autophagy Gene Atg16L1T300A Acts as a Dominant Negative Variant in Mice. (KO conditional)
P Gao; H Liu; H Huang; Q Zhang; W Strober; F Zhang
J Immunol., 2017 Mar 15;198(6):2457-2467. doi: 10.4049/jimmunol.1502652. Epub 2017 Feb 15.
Chinese Academy of Sciences, Beijing 100101, China. University of Chinese Academy of Sciences, Beijing 100049, China. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
3. Oral prion disease pathogenesis is impeded in the specific absence of CXCR5-expressing dendritic cells. (KO conditional)
BM Bradford; B Reizis; NA Mabbott
J Virol., 2017 Mar 8. pii: JVI.00124-17. doi: 10.1128/JVI.00124-17. [Epub ahead of print]
University of Edinburgh, Easter Bush EH25 9RG, United Kingdom. New York University Langone Medical Center, New York, NY USA.
4. New murine Niemann-Pick type C models bearing a pseudoexon-generating mutation recapitulate the main neurobehavioural and molecular features of the disease. (KI non-conditional)
M Gómez-Grau; J Albaigès; J Casas; C Auladell; M Dierssen; L Vilageliu; D Grinberg
Sci Rep., 2017 Feb 7;7:41931. doi: 10.1038/srep41931.
University of Barcelona, 08028 Barcelona, Spain. Institut de Biomedicina de la UB (IBUB)-Institut de Recerca Sant Joan de Déu (IRSJD), 08028 Barcelona, Spain. Centre for Biomedical Research on Rare Diseases (CIBERER), 08028 Barcelona, Spain. Barcelona Institute of Science and Technology, 08003 Barcelona, Spain. Departament de Química Biomèdica, Institut de Química Avançada de Catalunya (IQAC-CSIC), 08034 Barcelona, Spain. Pompeu Fabra University (UPF), 08003 Barcelona, Spain.
5. α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation. (KO conditional)
SS Kang; Z Zhang; X Liu; FP Manfredsson; L He; PM Iuvone; X Cao; YE Sun; L Jin; K Ye
Proc Natl Acad Sci U S A., 2017 Jan 31;114(5):1183-1188. doi: 10.1073/pnas.1618627114. Epub 2017 Jan 17.
Emory University School of Medicine, Atlanta, GA 30322. Michigan State University, Grand Rapids, MI 49503. Huazhong University of Science and Technology, Wuhan 430022, China. Tongji Hospital, Shanghai 200065, China. Tongji University School of Medicine, Shanghai 200065, China.
6. A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection. (KO conditional)
M Dutta; SJ Robertson; A Okumura; DP Scott; J Chang; JM Weiss; GL Sturdevant; F Feldmann; E Haddock; AL Chiramel; SS Ponia; JD Dougherty; MG Katze; AL Rasmussen; SM Best
Cell Rep., 2017 Jan 17;18(3):816-829. doi: 10.1016/j.celrep.2016.12.069.
School of Medicine, University of Washington, Seattle, WA 59105, USA. National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA. Columbia University, New York, NY 10032, USA.
7. Modelling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice. (KI non-conditional)
J Barman-Aksözen; P Ćwiek; VB Bansode; F Koentgen; J Trüb; P Pelczar; P Cinelli; X Schneider-Yin; D Schümperli; EI Minder
Dis Model Mech., 2017 Jan 12. pii: dmm.027755. doi: 10.1242/dmm.027755. [Epub ahead of print]
Municipal Hospital Triemli, 8063 Zurich, Switzerland. University of Bern, 3012 Bern, Switzerland. Ozgene Pty Ltd, Bentley, Perth, Western Australia, Australia. University of Basel, 4002 Basel, Switzerland. University Hospital Zurich, 8091 Zurich, Switzerland. Municipal Hospital Triemli, 8063 Zurich, Switzerland
8. First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15. (KO non-conditional)
JK Low; A Ambikairajah; K Shang; DA Brown; VW Tsai; SN Breit; T Karl
PLoS One., 2017 Jan 12;12(1):e0168416. doi: 10.1371/journal.pone.0168416. eCollection 2017.
Neuroscience Research Australia (NeuRA), Randwick, New South Wales, Australia. Western Sydney University, Campbelltown, New South Wales, Australia. St Vincent's Hospital, Darlinghurst, New South Wales, Australia. The Institute for Clinical Pathology and Medical Research and Westmead Hospital, Westmead, New South Wales, Australia

2016

9. Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy. (KI ROSA26)
C Altmann; S Hardt; C Fischer; J Heidler; HY Lim; A Häussler; B Albuquerque; B Zimmer; C Möser; C Behrends; F Koentgen; I Wittig; MH Schmidt; AM Clement; T Deller; I Tegeder
Neurobiol Dis., 2016 Dec;96:294-311. doi: 10.1016/j.nbd.2016.09.010. Epub 2016 Sep 11.
Goethe-University Hospital, Frankfurt, Germany. Johannes Gutenberg University, Mainz, Germany. Ozgene Pty Ltd, Bentley, WA, Australia.
10. Development and Validation of a New Mouse Model to Investigate the Role of SV2A in Epilepsy. (KO conditional)
C Menten-Dedoyart; ME Serrano Navacerrada; O Bartholome; J Sánchez Gil; V Neirinckx; S Wislet; G Becker; A Plenevaux; P Van den Ackerveken; B Rogister
PLoS One., 2016 Nov 18;11(11):e0166525. doi: 10.1371/journal.pone.0166525. eCollection 2016.
GIGA-Neurosciences, University of Liège, Liège, Belgium. Cyclotron Research Center, University of Liège, Liège, Belgium. Neurology Department, CHU, Academic Hospital, University of Liège, Liège, Belgium.
11. IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae (KO conditional)
K Chen; T Eddens; G Trevejo-Nunez; EE Way; W Elsegeiny; DM Ricks; AV Garg; CJ Erb; M Bo; T Wang; W Chen; JS Lee; SL Gaffen; JK Kolls
Cell Host & Microbe, 2016 Nov 9;20(5):596-605. doi: 10.1016/j.chom.2016.10.003
University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
12. Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets. (KI conditional)
SL French; AC Paramitha; MJ Moon; RA Dickins; JR Hamilton
PLoS One., 2016 Oct 27;11(10):e0165565. doi: 10.1371/journal.pone.0165565. eCollection 2016.
Australian Centre for Blood Diseases, Monash University, Melbourne, Australia.
13. Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration. (KI non-conditional)
Y Dong; R Fischer; PJ Naudé; O Maier; C Nyakas; M Duffey; EA Van der Zee; D Dekens; W Douwenga; A Herrmann; E Guenzi; RE Kontermann; K Pfizenmaier; UL Eisel
Proc Natl Acad Sci U S A., Proc Natl Acad Sci U S A.
University of Groningen, NL-9700 CC Groningen, The Netherlands. University of Stuttgart, 70569 Stuttgart, Germany. Semmelweis University, H-1088 Budapest, Hungary. Baliopharm AG, CH-4051 Basel, Switzerland.
14. An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation. (KI ROSA26)
G Segerer; K Hadamek; M Zundler; A Fekete; A Seifried; MJ Mueller; F Koentgen; M Gessler; E Jeanclos; A Gohla
Sci Rep., 2016 Oct 12;6:35160. doi: 10.1038/srep35160.
University of Würzburg, Würzburg, Germany. Ozgene Pty Ltd, Bentley, WA, Australia.
15. Critical Role of IL-22/IL22-RA1 Signaling in Pneumococcal Pneumonia. (KO conditional)
G Trevejo-Nunez; W Elsegeiny; P Conboy; K Chen; JK Kolls
J Immunol., 2016 Sep 1;197(5):1877-83. doi: 10.4049/jimmunol.1600528. Epub 2016 Jul 25.
Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA 15224.
16. Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus. (KI conditional)
RS Brown; IC Kokay; HR Phillipps; SH Yip; P Gustafson; A Wyatt; CM Larsen; P Knowles; SR Ladyman; P LeTissier; DR Grattan
J Neurosci., 2016 Aug 31;36(35):9173-85. doi: 10.1523/JNEUROSCI.1471-16.2016.
Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand. University of Edinburgh, Edinburgh EH8 9YL, United Kingdom. Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
17. Inhibition of CBLB protects from lethal Candida albicans sepsis. (KI non-conditional)
G Wirnsberger; F Zwolanek; T Asaoka; I Kozieradzki; L Tortola; RA Wimmer; A Kavirayani; F Fresser; G Baier; WY Langdon; F Ikeda; K Kuchler; JM Penninger
Nat Med., 2016 Aug;22(8):915-23. doi: 10.1038/nm.4134. Epub 2016 Jul 18.
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria. Max F. Perutz Laboratories (MFPL), Department of Medical Biochemistry, Vienna, Austria. Vienna Biocenter Core Facilities (VBCF), Vienna, Austria. Medical University Innsbruck, Innsbruck, Austria. University of Western Australia, Perth, Western Australia, Australia.
18. Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. (KI non-conditional)
Y Xiao; J Tang; H Guo; Y Zhao; R Tang; S Ouyang; Q Zeng; CA Rappleye; MV Rajaram; LS Schlesinger; L Tao; GD Brown; WY Langdon; BT Li; J Zhang
Nat Med., 2016 Aug;22(8):906-14. doi: 10.1038/nm.4141. Epub 2016 Jul 18.
Ohio State University, Columbus, Ohio, USA. Central South University, Changsha, P.R. China. Guangzhou Medical University, Guangzhou, P.R. China. University of South China, Changsha, P.R. China. University of Aberdeen, Aberdeen, UK. University of Western Australia, Crawley, Western Australia, Australia.
19. Hepatic overexpression of CD36 improves glycogen homeostasis and attenuates high-fat diet induced hepatic steatosis and insulin resistance. (KI ROSA26)
WG Garbacz; P Lu; TM Miller; SM Poloyac; NS Eyre; G Mayrhofer; M Xu; S Ren; W Xie
Mol Cell Biol., 2016 Aug 15. pii: MCB.00138-16.
University of Pittsburgh, Pittsburgh, Pennsylvania, USA. The University of Adelaide, Australia.
20. Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size. (KO conditional)
RB Perry; I Rishal; E Doron-Mandel; AL Kalinski; KF Medzihradszky; M Terenzio; S Alber; S Koley; A Lin; M Rozenbaum; D Yudin; PK Sahoo; C Gomes; V Shinder; W Geraisy; EA Huebner; CJ Woolf; A Yaron; AL Burlingame; JL Twiss; M Fainzilber
Cell Rep., 2016 Aug 9;16(6):1664-76. doi: 10.1016/j.celrep.2016.07.005. Epub 2016 Jul 28.
Weizmann Institute of Science, Rehovot 76100, Israel. University of South Carolina, Columbia, SC 29208; University of California, San Francisco, CA 94158; Boston Children's Hospital and Harvard Medical School, MA 02115, USA.
21. DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes. (KI non-conditional)
RW Maul; T MacCarthy; EG Frank; KA Donigan; MP McLenigan; W Yang; H Saribasak; DE Huston; SS Lange; R Woodgate; PJ Gearhart
J Exp Med., 2016 Jul 25. pii: jem.20151227.
National Institute on Aging, National Institutes of Health, Baltimore, MD 21224. State University of New York, Stony Brook, NY 11794. National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20850. University of Texas MD Anderson Cancer Center Science Park, Smithville, TX 78957.
22. Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. (KO conditional)
R Fan; A Toubal; S Goñi; K Drareni; Z Huang; F Alzaid; R Ballaire; P Ancel; N Liang; A Damdimopoulos; I Hainault; A Soprani; J Aron-Wisnewsky; F Foufelle; T Lawrence; JF Gautier; N Venteclef; E Treuter
Nat Med., 2016 Jul;22(7):780-91. doi: 10.1038/nm.4114. Epub 2016 Jun 6.
Karolinska Institutet, Huddinge, Sweden. Sorbonne Universités, Université Pierre et Marie-Curie, Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Cardiometabolism and Nutrition, Clinique Geoffroy Saint-Hilaire, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière, Lariboisière Hospital, University Paris-Diderot, Paris, France. Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille Université, Marseille, France.
23. Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice. (KO conditional)
LK Philp; TK Day; MS Butler; G Laven-Law; S Jindal; TE Hickey; HI Scher; LM Butler; WD Tilley
Sci Rep., 2016 Jun 30;6:28950. doi: 10.1038/srep28950.
Faculty of Health Sciences, University of Adelaide, Australia. Memorial Sloan Kettering Cancer Center, New York, USA.
24. Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration. (KO conditional)
TH Lo; PA Silveira; PD Fromm; ND Verma; PA Vu; F Kupresanin; R Adam; M Kato; VC Cogger; GJ Clark; DN Hart
J Immunol., 2016 Jun 17. pii: 1600259.
ANZAC Research Institute, Sydney, New South Wales 2139, Australia. Sydney Medical School, University of Sydney, Sydney, New South Wales 2006, Australia. Mater Medical Research Institute, Brisbane, Queensland 4101, Australia. Department of Haematology, Royal Prince Alfred Hospital, Sydney, New South Wales 2050, Australia.
25. Characterizing the molecular phenotype of an Atp7aT985I conditional knock in mouse model for X-linked distal hereditary motor neuropathy (dHMNX). (KI conditional)
G Perez-Siles; A Grant; M Ellis; C Ly; A Kidambi; M Khalil; RM Llanos; S Fontaine; AV Strickland; S Züchner; S Bermeo; E Neist; TC Brennan-Speranza; RI Takata; CE Speck-Martins; JF Mercer; GA Nicholson; ML Kennerson
Metallomics., 2016 Jun 13.
ANZAC Research Institute, Concord, NSW, Australia. University of Sydney, Sydney, NSW, Australia. School of Life and Environmental Sciences, Deakin University, Burwood, VIC, Australia. The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia. University of Miami Miller School of Medicine, Miami, FL, USA. Sarah Network Rehabilitation Hospitals, Brasilia, DF, Brazil. Concord Hospital, Concord, NSW, Australia.
26. Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion. (KO conditional)
BA Benz; S Nandadasa; M Takeuchi; RC Grady; H Takeuchi; RK LoPilato; S Kakuda; RP Somerville; SS Apte; RS Haltiwanger; BC Holdener
Dev Biol., 2016 Jun 10. pii: S0012-1606(16)30223-8. doi: 10.1016/j.ydbio.2016.05.038.
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, United States. Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States. Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, United States.
27. Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. (KO conditional)
Z Huang; D Sun; JX Hu; FL Tang; DH Lee; Y Wang; G Hu; XJ Zhu; J Zhou; L Mei; WC Xiong
J Neurosci., 2016 May 25;36(21):5833-49. doi: 10.1523/JNEUROSCI.4487-15.2016.
Charlie Norwood Veterans Administration Medical Center, Augusta, Georgia 30912. Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Northeast Normal University, Changchun, Jilin 130024, China. Xuzhou Medical College, Xuzhou, Jiangsu 221002, China. Key Laboratory of Laboratory Medicine (Wenzhou Medical University), Ministry of Education, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China. Medical College of Georgia, Augusta University, Augusta, Georgia 30912. Northeast Normal University, Changchun, Jilin 130024, China.
28. The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis. (KO/KI)
DC Ifrim; J Quintin; F Courjol; I Verschueren; JH van Krieken; F Koentgen; C Fradin; NA Gow; LA Joosten; JW van der Meer; F van de Veerkonk; MG Netea
J Interferon Cytokine Res., 2016 Apr;36(4):267-76. doi: 10.1089/jir.2015.0040. Epub 2016 Jan 27.
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Inserm U995, Lille, France; Université de Lille, Faculté de Médecine, Lille, France; Ozgene Pty Ltd, Bentley, WA, Australia; Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
29. TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis (KO conditional)
S Aizawa; T Okamoto; Y Sugiyama; T Kouwaki; A Ito; T Suzuki; C Ono; T Fukuhara; M Yamamoto; M Okochi; N Hiraga; M Imamura; K Chayama; R Suzuki; I Shoji; K Moriishi; K Moriya; K Koike; Y Matsuura
Nat Commun., 2016 May 4;7:11379. doi: 10.1038/ncomms11379.
Osaka University, Osaka, 565-0871, Japan. Hiroshima University School of Medicine, Hiroshima 734-8551, Japan. National Institute of Infectious Diseases, Tokyo 162-8640, Japan. Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. University of Yamanashi, Yamanashi 409-3898, Japan. The University of Tokyo, Tokyo 113-8655, Japan.
30. Exclusive transmission of embryonic stem cell-derived genome through the mouse germline. (KO/KI)
F Koentgen; J Lin; M Katidou; I Chang; M Khan; J Watts; P Mombaerts
Genesis, 2016 Mar 25. doi: 10.1002/dvg.22938. [Epub ahead of print]
Ozgene Pty Ltd, Bentley, WA, Australia. Max Planck Research Unit for Neurogenetics, Frankfurt, Germany.
31. Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice (KO conditional)
M Hellstrom; M Ericsson; B Johansson; M Faraz; F Anderson; R Henriksson; SK Nilsson; H Hedman
Am J Physiol Regul Integr Comp Physiol., 2016 Mar 23:ajpregu.00309.2015. doi: 10.1152/ajpregu.00309.2015. [Epub ahead of print]
Umeå University, SE-901 87 Umeå, Sweden
32. Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation. (KO conditional)
P Kumar; L Monin; P Castillo; W Elsegeiny; W Horne; T Eddens; A Vikram; M Good; AA Schoenborn; K Bibby; RC Montelaro; DW Metzger; AS Gulati; JK Kolls
Immunity., 2016 Mar 15;44(3):659-71. doi: 10.1016/j.immuni.2016.02.007.
University of Pittsburgh, Pittsburgh, PA 15224, USA. University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Albany Medical College, Albany, NY 12208, USA.
33. A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. (KO conditional)
C Spilker; S Nullmeier; KM Grochowska; A Schumacher; I Butnaru; T Macharadze; GM Gomes; P Yuanxiang; G Bayraktar; C Rodenstein; C Geiseler; A Kolodziej; J Lopez-Rojas; D Montag; F Angenstein; J Bär; W D'Hanis; T Roskoden; M Mikhaylova; E Budinger; FW Ohl; O Stork; AC Zenclussen; A Karpova; H Schwegler; MR Kreutz
PLoS Genet., 2016 Mar 15;12(3):e1005907. doi: 10.1371/journal.pgen.1005907. eCollection 2016.
Leibniz Institute for Neurobiology, Magdeburg, Germany. Otto-von-Guericke University, Magdeburg, Germany. Functional Neuroimaging Group, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Magdeburg, Germany. University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology, ZMNH, Hamburg, Germany.
34. Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration. (KO conditional)
SY Park; Y Yun; JS Lim; MJ Kim; SY Kim; JE Kim; IS Kim
Nat Commun., 2016 Mar 14;7:10871. doi: 10.1038/ncomms10871.
Dongguk University, Gyeongju 780-714, Republic of Korea. Kyungpook National University, Daegu 700-422, Republic of Korea. Asan Medical Center, Seoul 138-736, Republic of Korea. Korea Institute Science and Technology, Seoul 136-791, Republic of Korea. Korea University, Seoul 136-701, Republic of Korea.
35. Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gating. (KO conditional)
GC Carlson; RE Lin; Y Chen; BR Brookshire; RS White; I Lucki; SJ Siegel; SF Kim
Neuroscience., 2016 May 13;322:408-15. doi: 10.1016/j.neuroscience.2016.02.063. Epub 2016 Mar 3.
The Perlman School of Medicine at the University of Pennsylvania, Translational Research Building, Philadelphia, PA 19104, USA.
36. Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1. (KO conditional)
S Minocha; TL Sung; D Villeneuve; F Lammers; W Herr
Dev Biol., 2016 Feb 24. pii: S0012-1606(15)30319-5. doi: 10.1016/j.ydbio.2016.02.019. [Epub ahead of print]
Center for Integrative Genomics, Génopode, University of Lausanne, 1015 Lausanne, Switzerland.
37. Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. (KI conditional)
S Patial; AD Curtis; WS Lai; DJ Stumpo; GD Hill; GP Flake; MD Mannie; PJ Blackshear
Proc Natl Acad Sci U S A., 2016 Feb 16;113(7):1865-70. doi: 10.1073/pnas.1519906113. Epub 2016 Feb 1.
Signal Transduction Laboratory & Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Integrated Laboratory Systems, Research Triangle Park, NC, USA; East Carolina University Brody School of Medicine, Greenville, NC, USA; Duke University Medical Center, Durham, NC, USA.
38. Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice. (KO conditional)
CE Xirouchaki; SP Mangiafico; K Bate; Z Ruan; AM Huang; BW Tedjosiswoyo; B Lamont; W Pong; J Favaloro; AR Blair; JD Zajac; J Proietto; S Andrikopoulos
Mol Metab., 2016 Jan 21;5(3):221-32. doi: 10.1016/j.molmet.2016.01.004. eCollection 2016.
University of Melbourne, Heidelberg, Victoria, 3084, Australia.
39. Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice. (KO conditional)
L Tian; SC Choi; HN Lee; Y Murakami; CF Qi; M Sengottuvelu; O Voss; K Krzewski; JE Coligan
Cell Death Differ., 2016 Jan 15. doi: 10.1038/cdd.2015.161. [Epub ahead of print]
Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH: Pathology Core, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD, USA.
40. Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis. (Bruce4 ES cells)
S Kümper; FK Mardakheh; A McCarthy; M Yeo; GW Stamp; A Paul; J Worboys; A Sadok; C Jørgensen; S Guichard; CJ Marshall
Elife., 2016 Jan 14;5. pii: e12203. doi: 10.7554/eLife.12203. [Epub ahead of print]
Division of Cancer Biology, Institute of Cancer Research: Experimental Pathology Laboratory, Cancer Research UK London Research Institute, London, United Kingdom. Cancer Research UK Manchester Institute, Manchester, United Kingdom.
41. Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice. (KO conditional)
M Zheng; W Horne; JP McAleer; D Pociask; T Eddens; M Good; B Gao; JK Kolls
Infect Immun., 2016 Jan 4;84(3):782-9. doi: 10.1128/IAI.01268-15.
University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Tulane University ,New Orleans, Louisiana, USA. Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.

2015

42. Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice. (KI ROSA26)
KM McMurray; X Du; M Brownlee; AA Palmer
Behav Brain Res., 2015 Dec 19. pii: S0166-4328(15)30335-1. doi: 10.1016/j.bbr.2015.12.026.
University of Chicago, Chicago, IL, USA. Albert Einstein College of Medicine, Bronx, NY, USA. University of California San Diego, La Jolla, CA, USA.
43. Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment. (KO/KI)
DC Knutson; AM Mitzey; LE Talton; M Clagett-Dame
Brain Res., Dec 10. pii: S0006-8993(15)00944-0. doi: 10.1016/j.brainres.2015.12.005.
University of Wisconsin-Madison, Madison, WI, USA. University of California, Los Angeles, CA, USA.
44. Characterization of a genetically engineered mouse model of hemophilia A with complete deletion of the F8 gene. (KO conditional)
BN Chao; WH Baldwin; JF Healey; ET Parker; K Shafer-Weaver; C Cox; P Jiang; C Kanellopoulou; P Lollar; SL Meeks; MJ Lenardo
J Thromb Haemost, 2015 Nov 20. doi: 10.1111/jth.13202. [Epub ahead of print]
National Institutes of Health, Bethesda, MD; Emory University, Atlanta, GA, USA.
45. Helios Controls a Limited Subset of Regulatory T Cell Functions. (KO conditional)
M Sebastian; M Lopez-Ocasio; A Metidji; SA Rieder; EM Shevach; AM Thornton
J Immunol, 2015 Nov 18. pii: 1501704. [Epub ahead of print]
National Institutes of Health, Bethesda, MD, USA.
46. Discovery of the imidazole-derived GPR40 agonist AM-3189. (KO/KI)
Z Ma; DC Lin; R Sharma; J Liu; L Zhu; AR Li; T Kohn; Y Wang; JJ Liu; MD Bartberger; JC Medina; R Zhuang; L Li; J Zhang; J Luo; S Wong; GR Tonn; JB Houze
Bioorg Med Chem Lett., 2015 Nov 17. pii: S0960-894X(15)30258-4. doi: 10.1016/j.bmcl.2015.11.050. [Epub ahead of print]
Amgen Inc., South San Francisco, CA, USA.
47. Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography. (KI conditional)
B Zapiec; P Mombaerts
Proc Natl Acad Sci U S A., 2015 Oct 27;112(43):E5873-82. doi: 10.1073/pnas.1512135112. Epub 2015 Oct 8.
Max Planck Research Unit for Neurogenetics, Frankfurt, Germany; Institute of Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany.
48. Pappa2 deletion alters IGFBPs but has little effect on glucose disposal or adiposity. (KO conditional)
JK Christians; AK Bath; N Amiri
Growth Horm IGF Res., 2015 Oct;25(5):232-9. doi: 10.1016/j.ghir.2015.07.001. Epub 2015 Jul 7.
Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
49. Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation. (KO conditional)
RR Ramiscal; IA Parish; RS Lee-Young; JJ Babon; J Blagih; A Pratama; J Martin; N Hawley; JY Cappello; PF Nieto; JI Ellyard; NJ Kershaw; RA Sweet; CC Goodnow; RG Jones; MA Febbraio; CG Vinuesa; V Athanasopoulos
Elife., 2015 Oct 23;4. pii: e08698. doi: 10.7554/eLife.08698.
Department of Immunology and Infectious Disease, Australian National University, Canberra, Australia. Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Division of Structural Biology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. Department of Physiology, Goodman Cancer Research Centre, McGill University, Montreal, Canada. Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, Australia.
50. Response to Heard et al. (KO conditional)
M Moulin; AK Voss; T Thomas; WW Wong; WD Cook; F Koentgen; J Vince; J Silke; DL Vaux
EMBO J., 2015 Oct 1;34(19):2396-7. doi: 10.15252/embj.201592761.
Université Paris Sud, Paris, France; The University of Melbourne & La Trobe University, Melbourne, VIC, Australia; Ozgene Pty Ltd, Bentley, WA, Australia; University of Zürich, Zürich, Switzerland.
51. Pappa2 deletion in mice affects male but not female fertility. (KO conditional)
JK Christians; AY King; MD Rogowska; SM Hessels
Reprod Biol Endocrinol, 2015 Sep 29;13:109. doi: 10.1186/s12958-015-0108-y.
Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
52. Breeding Strategy Determines Rupture Incidence in Post-Infarct Healing WARPing Cardiovascular Research. (KO/KI)
S Deckx; P Carai; J Bateman; S Heymans; AP Papageorgiou
PLoS One, 2015 Sep 25;10(9):e0139199. doi: 10.1371/journal.pone.0139199. eCollection 2015.
Maastricht University, Maastricht, The Netherlands; Centre for Molecular and Vascular Biology, KULeuven, Leuven, Belgium; University of Melbourne, Victoria, Australia.
53. Fam83h null mice support a neomorphic mechanism for human ADHCAI (KO/KI)
SK Wang; Y Hu; J Yang; CE Smith; AS Richardson; Y Yamakoshi; YL Lee; F Seymen; M Koruyucu; K Gencay; M Lee; M Choi; JW Kim; JC Hu; JP Simmer
Wiley Periodicals, Inc., 21 Sep 2015, doi: 10.1002/mgg3.178
University of Michigan School of Dentistry, Michigan, USA; Peking University, Beijing, China; McGill University, Montreal, Canada; Tsurumi University, Yokohama, Japan; National Taiwan University, Taipei, Taiwan; Istanbul University, Istanbul, Turkey; Seoul National University, Seoul, Korea;
54. Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation. (KI conditional)
M Hasan; CS Fermaintt; N Gao; T Sakai; T Miyazaki; S Jiang; QZ Li; JP Atkinson; HC 3rd Morse; MA Lehrman; N Yan
Immunity, 2015 Sep 15;43(3):463-74. doi: 10.1016/j.immuni.2015.07.022. Epub 2015 Aug 25.
University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA; Washington University School of Medicine, St. Louis, MO 63110, USA.
55. PAPP-A2 expression by osteoblasts is required for normal postnatal growth in mice. (KO conditional)
N Amiri; JK Christians
Growth Horm IGF Res., 2015 Sep 11. pii: S1096-6374(15)30030-7. doi: 10.1016/j.ghir.2015.09.003. [Epub ahead of print]
Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
56. Generation and characterization of mice with a conditional null allele of the HtrA4 gene. (KO conditional)
J Liu; Y Li; J Hoh
Mol Med Rep., 2015 Sep 3. doi: 10.3892/mmr.2015.4291. [Epub ahead of print]
Yale University, New Haven, CT 06520, USA; Shandong University, Jinan, Shandong 250014, P.R. China.
57. MAR binding protein SMAR1 favors IL-10 mediated regulatory T cell function in acute colitis. (KO conditional)
B Mirlekar; S Patil; R Bopanna; S Chattopadhyay
Biochem Biophys Res Commun., 2015 Aug 21;464(2):647-53. doi: 10.1016/j.bbrc.2015.07.028. Epub 2015 Jul 10.
Chromatin and Disease Biology Laboratory, National Centre for Cell Science, Ganeshkhind, Pune 411007, India. Experimental Animal Facility, National Centre for Cell Science, Ganeshkhind, Pune 411007, India.
58. Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent. (KO/KI)
M Oosting; K Buffen; SC Cheng; IC Verschueren; F Koentgen; FL van de Veerdonk; MG Netea; LA Joosten
Cytokine, 2015 Aug 18. pii: S1043-4666(15)30044-2. doi: 10.1016/j.cyto.2015.08.005. [Epub ahead of print]
Radboud University Medical Centre, Nijmegen, The Netherlands; Ozgene Pty Ltd., Bentley, WA, Australia.
59. APP intracellular domain-WAVE1 pathway reduces amyloid-β production. (KO conditional)
I Ceglia; C Reitz; J Gresack; JH Ahn; V Bustos; M Bleck; X Zhang; G Martin; SM Simon; AC Nairn; P Greengard; Y Kim
Nat Med, 2015 Aug 17. doi: 10.1038/nm.3924. [Epub ahead of print]
The Rockefeller University, New York, USA; Columbia University, New York, USA; Ewha Womans University, Seoul, South Korea; Yale University School of Medicine, New Haven, Connecticut, USA.
60. The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. (KO conditional)
LM Ooms; LC Binge; EM Davies; P Rahman; JR Conway; R Gurung; DT Ferguson; A Papa; CG Fedele; JL Vieusseux; RC Chai; F Koentgen; JT Price; T Tiganis; P Timpson; CA McLean; CA Mitchell
Cancer Cell, 2015 Aug 10;28(2):155-69. doi: 10.1016/j.ccell.2015.07.003.
Monash University, Clayton, VIC, Australia; The Kinghorn Cancer Centre and University of NSW, Darlinghurst, Australia; Ozgene Pty Ltd, Bentley, WA, Australia; Alfred Hospital, Prahran, VIC, Australia.
61. Age-related hearing loss and degeneration of cochlear hair cells in mice lacking thyroid hormone receptor β1. (KO/KI)
L Ng; E Cordas; X Wu; KR Vella; AN Hollenberg; D Forrest
Endocrinology, 2015 Aug 4:en20151468. [Epub ahead of print]
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston.
62. The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice. (KI ROSA26)
B Chung; M Stadion; N Schulz; D Jain; S Scherneck; HG Joost; A Schürmann
Diabetologia, 2015 Aug 1. [Epub ahead of print]
Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rebruecke, Arthur-Scheunert-Allee 114-116, D-14558, Nuthetal, Germany.
63. Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration (KO conditional)
WN Yu; V Nogueira; A Sobhakumari; KC Patra; PT Bhaskar; N Hay
Cell Rep., 2015 Jul 28;12(4):610-21. doi: 10.1016/j.celrep.2015.06.057. Epub 2015 Jul 16.
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA. Research & Development Section, Jesse Brown VA Medical Center, Chicago, IL 60612, USA.
64. Differential Tissue-Specific Function of Adora2b in Cardioprotection. (KO conditional)
SW Seo; M Koeppen; S Bonney; M Gobel; M Thayer; PN Harter; K Ravid; HK Eltzschig; M Mittelbronn; L Walker; T Eckle
J Immunol., 2015 Aug 15;195(4):1732-43. doi: 10.4049/jimmunol.1402288. Epub 2015 Jul 1.
University of Colorado Denver, Aurora, CO 80045; Kyung Hee University, Seoul 130-701, Republic of Korea; Ludwig Maximilians University Munich, 80336 Munich, Germany; University of Frankfurt, 60528 Frankfurt, Germany; Boston University School of Medicine, Boston, MA 02118.
65. Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD). (KO conditional)
B Mirlekar; S Ghorai; M Khetmalas; R Bopanna; S Chattopadhyay
Mucosal Immunol., 2015 May 20. doi: 10.1038/mi.2015.42. [Epub ahead of print]
Chromatin and Disease Biology Laboratory, National Centre for Cell Science, Pune, India; DY Patil Institute of Bioinformatics and Biotechnology, Pune, India.
66. Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. (KO conditional)
N Bonhoure; A Byrnes; RD Moir; W Hodroj; F Preitner; V Praz; G Marcelin; SC Jr Chua; N Martinez-Lopez; R Singh; N Moullan; J Auwerx; G Willemin; H Shah; K Hartil; B Vaitheesvaran; I Kurland; N Hernandez; IM Willis
Genes Dev., 2015 May 1;29(9):934-47. doi: 10.1101/gad.258350.115.
Albert Einstein College of Medicine, Bronx, New York 10461, USA; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
67. Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice. (KO conditional)
D Boucher; T Vu; AL Bain; M Tagliaro-Jahns; W Shi; SW Lane; KK Khanna
FASEB J., 2015 Apr 27. pii: fj.14-269944. [Epub ahead of print]
Signal Transduction Laboratory, Translational Leukaemia Research, QIMR Berghofer Medical Research Institute, Herston, Australia; University of Queensland, Brisbane, Australia; Institut National De La Recherche Agronomique, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Équipes de Recherche Labellisées Centre National de la Recherche Scientifique 3559, Saclay Plant Sciences, Versailles, France.
68. Inductively coupled mass spectrometry analysis of biometals in conditional Hamp1 and Hamp1 and Hamp2 transgenic mouse models. (KO conditional)
S Lu; J Seravalli; D Harrison-Findik
Transgenic Res., 2015 Apr 23. [Epub ahead of print]
University of Nebraska Medical Center, Omaha, NE, USA.
69. Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. (KO conditional)
J Li; SF Jørgensen; SM Maggadottir; M Bakay; K Warnatz; J Glessner; R Pandey; U Salzer; RE Schmidt; E Perez; E Resnick; S Goldacker; M Buchta; T Witte; L Padyukov; V Videm; T Folseraas; F Atschekzei; JT Elder; RP Nair; J Winkelmann; C Gieger; MM Nöthen; C Büning; S Brand; KE Sullivan; JS Orange; B Fevang; S Schreiber; W Lieb; P Aukrust; H Chapel; C Cunningham-Rundles; A Franke; TH Karlsen; B Grimbacher; H Hakonarson; L Hammarström; E Ellinghaus
Nat Commun., 2015 Apr 20;6:6804. doi: 10.1038/ncomms7804.
Children's Hospital of Philadelphia & University of Pennsylvania, PA, USA. Oslo University Hospital, Norway. University of Freiburg, Germany. Hannover Medical School, Germany. University of Miami Miller School of Medicine, FL, USA. Mount Sinai School of Medicine, New York, NY, USA. Karolinska Institutet, Stockholm, Sweden. Norwegian University of Science and Technology, Trondheim, Norway. University of Michigan, Ann Arbor, MI, USA. German Research Center for Environmental Health, Neuherberg, Germany. Technische Universität München, Germany. Stanford Center for Sleep Sciences and Medicine, Palo Alto, CA, USA. University of Bonn, Germany. Charité, Berlin, Germany. University Hospital Munich-Grosshadern, Munich, Germany. Texas Children's Hospital, Houston, TX, USA. Christian-Albrechts-University, Kiel, Germany. University of Oxford, UK. Karolinska University Hospital, Huddinge, Sweden.
70. Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus. (KO conditional)
G Jung; EJ Kim; A Cicvaric; S Sase; M Gröger; H Höger; FJ Sialana; J Berger; FJ Monje; G Lubec
J Neurochem., 2015 Apr 11. doi: 10.1111/jnc.13119. [Epub ahead of print]
Medical University of Vienna, Austria.
71. Anti-PCSK9 Antibody Pharmacokinetics and Low-Density Lipoprotein-Cholesterol Pharmacodynamics in Nonhuman Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to Neonatal Fc Receptor-Binding Enhancement. (KO conditional)
KR Henne; B Ason; M Howard; W Wang; J Sun; J Higbee; J Tang; KC Matsuda; R Xu; L Zhou; JC Chan; C King; DE Piper; RR Ketchem; ML Michaels; SM Jackson; MW Retter
J Pharmacol Exp Ther., 2015 Apr;353(1):119-31. doi: 10.1124/jpet.114.221242. Epub 2015 Feb 4.
Amgen, South San Francisco, California, USA.
72. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice. (KI non-conditional)
M Yue; K Hinkle; P Davies; E Trushina; F Fiesel; T Christenson; A Schroeder; L Zhang; E Bowles; B Behrouz; S Lincoln; J Beevers; A Milnerwood; A Kurti; PJ McLean; JD Fryer; W Springer; D Dickson; M Farrer; H Melrose
Neurobiol Dis., 2015 Mar 31. pii: S0969-9961(15)00099-6. doi: 10.1016/j.nbd.2015.02.031.
Mayo Clinic Jacksonville, Jacksonville FL 32224, USA; University of Dundee, DD1 4HN, Scotland, UK; Mayo Clinic College of Medicine and Mayo Clinic Rochester, Rochester, MN 55905, USA; Center for Applied Genetics, University of British Columbia, V6T 2B5, Canada.
73. Epithelial NAIPs protect against colonic tumorigenesis. (KO non-conditional)
R Allam; MH Maillard; A Tardivel; V Chennupati; H Bega; CW Yu; D Velin; P Schneider; KM Maslowski
J Exp Med., 2015 Mar 9;212(3):369-83. doi: 10.1084/jem.20140474. Epub 2015 Mar 2.
Ludwig Center for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland; Switzerland Universitätsklinik für Hämatologie und Hämatologisches Zentrallabor, Inselspital/Universitätsspital, 3010 Bern, Switzerland; Lausanne University Hospital, 1015 Lausanne, Switzerland; RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
74. Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease. (KO conditional)
SV Chemmannur; AJ Badhwar; B Mirlekar; SK Malonia; M Gupta; N Wadhwa; R Bopanna; U Mabalirajan; S Majumdar; B Ghosh; S Chattopadhyay
Mucosal Immunol., 2015 Mar 4. doi: 10.1038/mi.2015.11. [Epub ahead of print]
National Centre for Cell Science, Pune University, Pune, India. Piramal Enterprises, Nirlon Complex, Mumbai, India. University of Massachusetts Medical School, Worcester, Massachusetts, USA. National Institute of Immunology, New Delhi, India. 5CSIR-Institute of Genomic and Integrative Biology, New Delhi, India.
75. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. (KO conditional)
X Zhu; JS Messer; Y Wang; F Lin; CM Cham; J Chang; TR Billiar; MT Lotze; DL Boone; EB Chang
J Clin Invest., 2015 Feb 2. pii: 76344. doi: 10.1172/JCI76344. [Epub ahead of print]
Department of Medicine, University of Chicago, Chicago, Illinois, USA. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
76. Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse. (KI conditional)
CM Karsten; Y Laumonnier; B Eurich; F Ender; K Bröker; S Roy; A Czabanska; T Vollbrandt; J Figge; J Köhl
J Immunol., 2015 Jan 14. pii: 1401401. [Epub ahead of print]
Institute for Systemic Inflammation Research, Cell Analysis Core, Institute for Systemic Inflammation Research, University of Lübeck, 23538 Lübeck, Germany. Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
77. The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets. (KI conditional)
CE Hughes; BA Finney; F Koentgen; KL Lowe; SP Watson
Blood, 2015 Jan 1;125(1):144-54. doi: 10.1182/blood-2014-05-579375. Epub 2014 Oct 28.
University of Birmingham, Birmingham, United Kingdom; Ozgene Pty Ltd, Bentley, WA, Australia.

2014

78. Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1. (KO conditional)
VL Patterson; AJ Zullo; C Koenig; S Stoessel; H Jo; X Liu; J Han; M Choi; AT DeWan; JL Thomas; CY Kuan; J Hoh
PLoS One, 2014 Dec 22;9(12):e115789. doi: 10.1371/journal.pone.0115789. eCollection 2014.
Yale University School of Medicine, New Haven, Connecticut, USA; Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
79. Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development. (KO conditional)
SA Ramsbottom; V Sharma; HJ Rhee; L Eley; HM Phillips; HF Rigby; C Dean; B Chaudhry; DJ Henderson
PLoS Genet., 2014 Dec 18;10(12):e1004871. doi: 10.1371/journal.pgen.1004871. eCollection 2014.
Institute of Genetic Medicine, Newcastle University, Centre for Life, Newcastle upon Tyne, UK; National Heart and Lung Institute, Imperial College London, London, UK; Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK.
80. Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain. (KO/KI)
VC Wimmer; RC Harty; KL Richards; AM Phillips; H Miyazaki; N Nukina; S Petrou
J Comp Neurol., 2014 Nov 25. doi: 10.1002/cne.23715. [Epub ahead of print]
Florey Institute of Neuroscience and Mental Health, Cnr Genetics Lane and Royal Parade, Victoria, 3010, Australia.
81. Positron emission tomography and functional characterization of a complete PBR/TSPO knockout. (KO conditional)
RB Banati; RJ Middleton; R Chan; CR Hatty; W Wai-Ying Kam; C Quin; MB Graeber; A Parmar; D Zahra; P Callaghan; S Fok; NR Howell; M Gregoire; A Szabo; T Pham; E Davis; GJ Liu
Nat Commun., 2014 Nov 19;5:5452. doi: 10.1038/ncomms6452.
Life Sciences, Australian Nuclear Science and Technology Organisation, New South Wales 2232, Australia; Medical Imaging & Radiation Sciences, Faculty of Health Science and Brain & Mind Research Institute, The University of Sydney, Sydney, New South Wales 2
82. Nox2 Knockout Delays Infarct Progression and Increases Vascular Recovery through Angiogenesis in Mice following Ischaemic Stroke with Reperfusion. (KO conditional)
SK McCann; GJ Dusting; CL Roulston
PLoS One, 2014 Nov 6;9(11):e110602. doi: 10.1371/journal.pone.0110602. eCollection 2014.
O'Brien Institute, St Vincent's Hospital, Melbourne, Victoria, Australia; Centre for Eye Research, the Royal Eye and Ear Hospital, Melbourne, Victoria, Australia; University of Melbourne, Victoria, Australia.
83. GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment. (KO conditional)
X Wang; H Sumida; JG Cyster
J Exp Med., 2014 Oct 27. pii: jem.20140646. [Epub ahead of print]
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143
84. Ly49E Expression on CD8αα-Expressing Intestinal Intraepithelial Lymphocytes Plays No Detectable Role in the Development and Progression of Experimentally Induced Inflammatory Bowel Diseases. (KO conditional)
A Van Acker; J Filtjens; S Van Welden; S Taveirne; E Van Ammel; M Vanhees; L Devisscher; T Kerre; T Taghon; B Vandekerckhove; J Plum; G Leclercq
PLoS One, 2014 Oct 13;9(10):e110015. doi: 10.1371/journal.pone.0110015. eCollection 2014.
Department of Clinical Chemistry, Microbiology and Immunology, and Department of Gastroenterology, Ghent University, Ghent, Belgium.
85. SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation. (KO conditional)
N Chaudhary; KK Nakka; PL Chavali; J Bhat; S Chatterjee; S Chattopadhyay
Cell Death Dis., 2014 Oct 9;5:e1447. doi: 10.1038/cddis.2014.397.
Chromatin and Disease Biology Laboratory, National Centre for Cell Science, Pune University Campus, Pune, India. Department of Biophysics, Bose Institute, Kolkata, India.
86. Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. (KO/KI)
C Schreiweis; U Bornschein; E Burguière; C Kerimoglu; S Schreiter; M Dannemann; S Goyal; E Rea; CA French; R Puliyadi; M Groszer; SE Fisher; R Mundry; C Winter; W Hevers; S Pääbo; W Enard; AM Graybiel
Proc Natl Acad Sci U S A, 2014 Sep 30;111(39):14253-8. doi: 10.1073/pnas.1414542111.
McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Ger
87. PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol and atherosclerosis in the absence of ApoE. (KO non-conditional)
B Ason; JW van der Hoorn; J Chan; E Lee; EJ Pieterman; KK Nguyen; M Di; S Shetterly; J Tang; WC Yeh; M Schwarz; JW Jukema; R Scott; SM Wasserman; HM Princen; S Jackson
J Lipid Res., 2014 Sep 25. pii: jlr.M053207. [Epub ahead of print]
Amgen, Inc, Thousand Oaks, CA, United States; TNO - Metabolic Health Research, Netherlands; Leiden University Medical Center, Netherlands.
88. The Role of p75NTR in Cholinergic Basal Forebrain Structure and Function. (KO/KI)
Z Boskovic; F Alfonsi; BA Rumballe; S Fonseka; F Windels; EJ Coulson
J Neurosci., 2014 Sep 24;34(39):13033-8. doi: 10.1523/JNEUROSCI.2364-14.2014.
Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia.
89. Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice (KI non-conditional)
DA Beccano-Kelly; N Kuhlmann; I Tatarnikov; M Volta; LN Munsie; P Chou; LP Cao; H Han; L Tapia; MJ Farrer; AJ Milnerwood
Front. Cell. Neurosci., doi: 10.3389/fncel.2014.00301
University of British Columbia, Canada
90. Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β-cell, regeneration. (KO/KI)
CH Chung; A Miller; A Panopoulos; E Hao; R Margolis; A Terskikh; F Levine
Physiol Rep., 2014 Sep 4;2(9). pii: e12131. doi: 10.14814/phy2.12131. Print 2014 Sep 1.
Sanford-Burnham Medical Research Institute, La Jolla, California.
91. A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation. (KI non-conditional)
H Wang; M Yan; J Sun; S Jain; R Yoshimi; SM Abolfath; K Ozato; VG Jr Coleman; AP Ng; D Metcalf; L DiRago; SL Nutt; HC 3rd Morse
J Immunol., 2014 Aug 15;193(4):1766-77. doi: 10.4049/jimmunol.1301939. Epub 2014 Jul 14.
National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Department of Internal M
92. Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer. (KO conditional)
TW Owens; RL Rogers; S Best; A Ledger; AM Mooney; A Ferguson; P Shore; A Swarbrick; CJ Ormandy; PT Simpson; JS Carroll; JE Visvader; MJ Naylor
Cancer Res., 2014 Jul 23. pii: canres.0053.2014.
School of Medical Sciences, University of Sydney. Kinghorn Cancer Centre, Garvan Institute of Medical Research, Melbourne. ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research. Faculty of Lifes Sciences, The Universit
93. Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland. (KO conditional)
JM Cunnick; S Kim; J Hadsell; S Collins; C Cerra; P Reiser; DC Flynn; Y Cho
Oncogene, 2014 Jul 21;0. doi: 10.1038/onc.2014.205. [Epub ahead of print]
Department of Basic Sciences, The Commonwealth Medical College, Scranton, PA, USA. Graduate School of Medicine, The Commonwealth Medical College, Scranton, PA, USA. Fortis Institute Scranton, Scranton, PA, USA. Department of Pathology, Pocono Health Syst
94. Netrin-1 controls sympathetic arterial innervation. (KO conditional)
I Brunet; E Gordon; J Han; B Cristofaro; D Broqueres-You; C Liu; K Bouvrée; J Zhang; R Del Toro; T Mathivet; B Larrivée; J Jagu; L Pibouin-Fragner; L Pardanaud; MJ Machado; TE Kennedy; Z Zhuang; M Simons; BI Levy; M Tessier-Lavigne; A Grenz; H Eltzschig; A Eichmann
J Clin Invest, 2014 Jul 1;124(7):3230-40. doi: 10.1172/JCI75181.
Centre Interdisciplinaire de Recherche en Biologie (CIRB), Collège de France, Inserm U1050/CNRS UMR7241, Paris, France. Paris Cardiovascular Research Center (PARCC), INSERM U970, Paris, France. Yale Cardiovascular Research Center, Yale University School
95. The diabetes susceptibility gene clec16a regulates mitophagy. (KO conditional)
SA Soleimanpour; A Gupta; M Bakay; AM Ferrari; DN Groff; J Fadista; LA Spruce; JA Kushner; L Groop; SH Seeholzer; BA Kaufman; H Hakonarson; DA Stoffers
Cell, 2014 Jun 19;157(7):1577-90. doi: 10.1016/j.cell.2014.05.016.
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine and the Institute for Diabetes, Obesity and Metabolism of the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Metabolism, Endo
96. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice. (KI non-conditional)
HM O'Neill; JS Lally; S Galic; M Thomas; PD Azizi; MD Fullerton; BK Smith; T Pulinilkunnil; Z Chen; MC Samaan; SB Jorgensen; JR Dyck; GP Holloway; TJ Hawke; BJ van Denderen; BE Kemp; GR Steinberg
Diabetologia, 2014 Aug;57(8):1693-702. doi: 10.1007/s00125-014-3273-1. Epub 2014 Jun 10.
Division of Endocrinology and Metabolism, Department of Medicine, HSC 4N63, McMaster University, 1280 Main St West, Hamilton, ON, Canada, L8N 3Z5.
97. Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndrome. (KO/KI)
CA Reid; B Leaw; KL Richards; R Richardson; V Wimmer; C Yu; EL Hill-Yardin; H Lerche; IE Scheffer; SR Berkovic; S Petrou
Brain., 2014 Jun;137(Pt 6):1701-15. doi: 10.1093/brain/awu077.
Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Parkville, 3010, Australia. Department of Neurology and Epileptology, Hertie Institute of Clinical Brain Research, University of Tübingen, Germany. Neurological Clinic and
98. Facilitation of endoglin-targeting cancer therapy by development/utilization of a novel genetically engineered mouse model expressing humanized endoglin (CD105). (Not categorised)
H Toi; M Tsujie; Y Haruta; K Fujita; J Duzen; BK Seon
Int J Cancer, 2014 May 28. doi: 10.1002/ijc.28994. [Epub ahead of print]
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY; Department of Surgery, Megumino Hospital, Eniwa, Hokkaido, Japan.
99. Characterization of the Mitofusin 2 R94W Mutation in a Knock-in Mouse Model. (KI conditional)
AV Strickland; AP Rebelo; F Zhang; J Price; B Bolon; JP Silva; R Wen; S Züchner
J Peripher Nerv Syst., 2014 May 23. doi: 10.1111/jns5.12066.
Department of Human Genetics and Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL.
100. Stress- and diet-induced fat gain is controlled by NPY in catecholaminergic neurons (KO/KI)
L Zhang; ICJ Lee; RF Enriquez; J Lau; LH Vähätalo; PA Baldock; E Savontaus; H Herzog
Molecular Metabolism, 16 May 2014 (10.1016/j.molmet.2014.05.001)
Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney 2010, Australia Faculty of Medicine, UNSW Australia, Sydney 2052, Australia
101. Optimization of GPR40 Agonists for Type 2 Diabetes (KO/KI)
JJ Liu; Y Wang; Z Ma; M Schmitt; L Zhu; SP Brown; PJ Dransfield; Y Sun; R Sharma; Q Guo; R Zhuang; J Zhang; J Luo; GR Tonn; S Wong; G Swaminath; JC Medina; DCH Lin; JB Houze
ACS Med. Chem. Lett., 2014, 5 (5), pp 517–521
Department of Therapeutic Discovery, Metabolic Disorders, Translational Sciences, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, United States
102. Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells. (KI non-conditional)
J Jacobsen; OA Haabeth; AA Tveita; KW Schjetne; LA Munthe; B Bogen
J Immunol., 2014 May 1;192(9):4174-83. doi: 10.4049/jimmunol.1302359. Epub 2014 Apr 4.
Centre for Immune Regulation, Oslo University Hospital, University of Oslo, N-0372 Oslo, Norway
103. Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells. (KO conditional)
Y Chaly; HC Blair; SM Smith; DS Bushnell; AD Marinov; BT Campfield; R Hirsch
Ann Rheum Dis., 2014 Mar 21. doi: 10.1136/annrheumdis-2013-204822. [Epub ahead of print]
Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
104. The co-repressor Rcor1 is essential for murine erythropoiesis. (KO conditional)
H Yao; DC Goldman; T Nechiporuk; S Kawane; SK McWeeney; TW Tyner; G Fan; MA Kerenyi; SH Orkin; WH Fleming; G Mandel
Blood, 2014 Mar 20. [Epub ahead of print]
Vollum Institute, Howard Hughes Medical Institute, Oregon Health & Science University, Portland, OR, United States
105. Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy. (KO/KI)
RJ Hatch ; CA Reid; S Petrou
Epilepsia, 2014 Mar 7. doi: 10.1111/epi.1
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
106. A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism. (KI conditional)
S Hasan; DR van der Veen; R Winsky-Sommerer ; A Hogben; EE Laing; F Koentgen; DJ Dijk; SN Archer
FASEB J, 2014 Mar 5. [Epub ahead of print]
Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
107. Physiological expression of the PI3K-activating mutation Pik3caH1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice. (KI conditional)
LM Hare; TJ Phesse; PM Waring; KG Montgomery; KM Kinross; K Mills; V Roh; JK Heath; RG Ramsay; M Ernst; WA Phillips
The Biochemical journal, 2014 Mar 1;458(2):251-8. doi: 10.1042/BJ20131412.
Department of Pathology, University of Melbourne, Parkville, VIC, Australia. Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.
108. The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. (KO/KI)
Y Yoshida; R Yoshimi; H Yoshii; D Kim; A Dey; H Xiong; J Munasinghe; I Yazawa; MJ O'Donovan; OA Maximova; S Sharma; J Zhu; H Wang; HC 3rd Morse; K Ozato
Immunity, 2014 Feb 20;40(2):187-98. doi: 10.1016/j.immuni.2013.11.022.
NICHD, NINDS, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. Mount Sinai School of Medicine, New York, NY 10029, USA.
109. Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages. (KO conditional)
A Nikolaou; B Stijlemans; D Laoui; E Schouppe; HT Tran; D Tourwé; SY Chai; PM Vanderheyden; JA Van Ginderachter
Journal of the renin-angiotensin-aldosterone system : JRAAS, 2014 Feb 14. [Epub ahead of print]
Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel, Belgium
110. Transforming Growth Factor β-induced Protein Promotes Severe Vascular Inflammatory Responses. (KO conditional)
JS Bae; W Lee; JO Nam; JE Kim; SW Kim; IS Kim
American journal of respiratory and critical care medicine, 2014 Feb 7. [Epub ahead of print]
Kyungpook National University, Daegu, Republic of Korea
111. S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant (KO/KI)
Greenwald SH; Kuchenbecker JA; Roberson DK; Nietz M; Nietz J
Visual Neuroscience, 31, pp 25-37. doi:10.1017/S0952523813000515.
Vision Sciences, University of Washington, Seattle, Washington
112. p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression. (KO conditional)
L Tian; SC Choi; Y Murakami; J Allen; HC Morse Iii; CF Qi; K Krzewski; JE Coligan
Nature communications, 2014 Jan 30;5:3146. doi: 10.1038/ncomms4146.
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.
113. Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages. (KO conditional)
Y Chaly; Y Fu; A Marinov; B Hostager; W Yan; B Campfield; JA Kellum; D Bushnell; Y Wang; J Vockley; R Hirsch
European journal of immunology, 2014 Jan 28. doi: 10.1002/eji.201344063. [Epub ahead of print]
Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

2013

114. Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular HMGB1 in cellular protection. (KO conditional)
Huang H; Nace GW; McDonald KA; Tai S; Klune JR; Rosborough BR; Ding Q; Loughran P; Zhu X; Beer-Stolz; Chang EB; Billiar T; Tsung A
Hepatology (Baltimore, Md.), 2013 Dec 21. doi: 10.1002/hep.26976. [Epub ahead of print]
Department Of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
115. The role of Dectin-2 for host defense against systemic infection with Candida glabrata. (KO conditional)
Ifrim DC; Bain JM; Reid DM; Oosting M; Verschueren I; Gow NA; van Krieken JH; Brown GD; Kullberg BJ; Joosten LA; van der Meer JW; Koentgen F; Erwig LP; Quintin J; Netea MG
Infection and immunity, Infect Immun. 2013 Dec 16. [Epub ahead of print]
Department of Internal Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands.
116. Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks. (KO/KI)
M Chopin; C Seillet; S Chevrier; L Wu; HC 3rd Morse; GT Belz; ST Nutt
J Exp Med, 2013 Dec 16;210(13):2967-80. doi: 10.1084/jem.20130930.
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
117. Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation. (KI ROSA26)
E Rodríguez-Gallego; M Riera-Borrull; A Hernández-Aguilera; R Mariné-Casadó; A Rull; R Beltrán-Debón; F Luciano-Mateo; JA Menendez; A Vazquez-Martin; JJ Sirvent; V Martín-Paredero; AL Corbí; E Sierra-Filardi; G Aragonès; A García-Heredia; J Camps; C Alonso-Villaverde; J Joven
Mediators of inflammation, 2013;2013:953841. doi: 10.1155/2013/953841. Epub 2013 Dec 15.
Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Spain ; Campus of International Excellence Southern Catalonia, Spain. Catalan I
118. Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. (KI conditional)
V Marsh Durban; MM Deuker; MW Bosenberg; W Phillips; M McMahon
The Journal of clinical investigation, 2013 Dec 2;123(12):5104-18. doi: 10.1172/JCI69619. Epub 2013 Nov 8.
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA
119. Normal Autophagic Activity in Macrophages from Mice Lacking Gαi3, AGS3, or RGS19. (KI non-conditional)
A Vural; TJ McQuiston; JB Blumer; C Park; IY Hwang; Y Williams-Bey; CS Shi; DZ Ma; JH Kehrl
PloS one, 2013 Nov 28;8(11):e81886. doi: 10.1371/journal.pone.0081886.
B-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
120. Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice. (KI non-conditional)
EA Jacobsen; WE Lesuer; L Willetts; KR Zellner; K Mazzolini; N Antonios; B Beck; C Protheroe; SI Ochkur; D Colbert; P Lacy; R Moqbel; J Appleton; NA Lee; JJ Lee
Allergy, 2013 Nov 25. doi: 10.1111/all.12321. [Epub ahead of print]
Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA, USA.
121. Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases. (KO conditional)
GL Vilas; SK Loganathan; J Liu; AK Riau; JD Young; JS Mehta; EN Vithana; JR Casey
Human molecular genetics, 2013 Nov 15;22(22):4579-90. doi: 10.1093/hmg/ddt307.
Membrane Protein Disease Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
122. Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality. (KO/KI)
MG Gall; Y Chen; AJ Vieira de Ribeiro; H Zhang; CG Bailey; DS Spielman; DM Yu; MD Gorrell
PloS one, 2013 Nov 6;8(11):e78378. doi: 10.1371/journal.pone.0078378.
Centenary Institute, Camperdown and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
123. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. (KI non-conditional)
MD Fullerton; S Galic; K Marcinko; S Sikkema; T Pulinilkunnil; ZP Chen; HM O'Neill; RJ Ford; R Palanivel; M O'Brien; DG Hardie; SL Macaulay; JD Schertzer; JR Dyck; BJ van Denderen; BE Kemp; GR Steinberg
Nature medicine, 2013 Nov 3. doi: 10.1038/nm.3372. [Epub ahead of print]
Department of Medicine, Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
124. Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression. (KI conditional)
CL Trejo; S Green; V Marsh; EA Collisson; G Iezza; WA Phillips; M McMahon
Cancer research, 2013 Nov 1;73(21):6448-61. doi: 10.1158/0008-5472.CAN-13-0681. Epub 2013 Sep 9.
Helen Diller Family Comprehensive Cancer Center. Departments of Cell and Molecular Pharmacology. Hematology and Oncology, and Pathology. University of California, San Francisco. San Francisco, California. Surgical Oncology Research Laboratory. Sir Peter M
125. Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction. (KO conditional)
R Xu; BD Paul; DR Smith; R Tyagi; F Rao; AB Khan; DJ Blech; MS Vandiver; MM Harraz; P Guha; I Ahmed; N Sen; M Gallagher; SH Snyder
Proceedings of the National Academy of Sciences of the United States of America, 2013 Oct 1;110(40):16181-16186. Epub 2013 Sep 16.
The Solomon H. Snyder Department of Neuroscience, Department of Pharmacology and Molecular Sciences, and Medical Scientist Training Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
126. Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy. (KO conditional)
SB Han; HP Ang; R Poh; SS Chaurasia; G Peh; J Liu; DT Tan; EN Vithana; JS Mehta
Investigative ophthalmology & visual science, 2013 Sep 27;54(9):6179-89. doi: 10.1167/iovs.13-12089.
Singapore National Eye Centre, Singapore.
127. Kruppel-like factor 15 is critical for vascular inflammation. (KO conditional)
Y Lu; L Zhang; X Liao; P Sangwung; DA Prosdocimo; G Zhou; AR Votruba; L Brian; YJ Han; H Gao; Y Wang; K Shimizu; K Weinert-Stein; M Khrestian; DI Simon; NJ Freedman; MK Jain
The Journal of clinical investigation, 2013 Sep 3. pii: 68552. doi: 10.1172/JCI68552. [Epub ahead of print]
128. The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice. (KO conditional)
M Iguchi; M Osanai; Y Hayashi; F Koentgen; GH Lee
Oncogene, 2013 Aug 19. doi: 10.1038/onc.2013.331. [Epub ahead of print]
Department of Pathology, Kochi University School of Medicine, Kochi, Japan.
129. Loss of the Nuclear Receptor Corepressor SLIRP Compromises Male Fertility. (KO conditional)
SM Colley; L Wintle; R Searles; V Russell; RC Firman; S Smith; K Deboer; DJ Merriner; B Genevieve; JM Bentel; BG Stuckey; MR Phillips; LW Simmons; DM de Kretser; MK O'Bryan; PJ Leedman
PloS one, 2013 Aug 15;8(8):e70700. doi: 10.1371/journal.pone.0070700.
Laboratory for Cancer Medicine, The University of Western Australia Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia.
130. Genetic Deletion of Cell Division Autoantigen 1 Retards Diabetes-Associated Renal Injury. (KO conditional)
Z Chai; A Dai; Y Tu; J Li; T Wu; Y Wang; LJ Hale; F Koentgen; MC Thomas; ME Cooper
Journal of the American Society of Nephrology : JASN, 2013 Aug 8. [Epub ahead of print]
Proliferation and Fibrosis Laboratory.
131. IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. (KO conditional)
KE Hamilton; FK Noubissi; PS Katti; CM Hahn; SR Davey; ET Lundsmith; AJ Klein-Szanto; AD Rhim; VS Spiegelman; AK Rustgi
Carcinogenesis, 2013 Jul 11. [Epub ahead of print]
Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
132. Loss of Usp9x Disrupts Cortical Architecture, Hippocampal Development and TGFβ-Mediated Axonogenesis. (KO conditional)
S Stegeman; LA Jolly; S Premarathne; J Gecz; LJ Richards; A Mackay-Sim; SA Wood
PloS one, 2013 Jul 5;8(7):e68287. doi: 10.1371/journal.pone.0068287. Print 2013.
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia.
133. Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. (KO conditional)
P Nagarajan; Z Ge; B Sirbu; C Doughty; PA Agudelo Garcia; M Schlederer; AT Annunziato; D Cortez; L Kenner; MR Parthun
PLoS genetics, 2013 Jun;9(6):e1003518. doi: 10.1371/journal.pgen.1003518. Epub 2013 Jun 6.
Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA.
134. Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells. (KO conditional)
C Xing; X Fu; X Sun; P Guo; M Li; JT Dong
PloS one, 2013 Jun 5;8(6):e65538. doi: 10.1371/journal.pone.0065538. Print 2013.
Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin, China.
135. Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. (KO conditional)
FH Beraldo; IN Soares; DF Goncalves; J Fan; AA Thomas; TG Santos; AH Mohammad; M Roffé; MD Calder; S Nikolova; GN Hajj; AL Guimaraes; AR Massensini; I Welch; DH Betts; R Gros; M Drangova; AJ Watson; R Bartha; VF Prado; VR Martins; MA Prado
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013 May 31. [Epub ahead of print]
Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.
136. Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils. (KI non-conditional)
AD Doyle; EA Jacobsen; SI Ochkur; L Willetts; K Shim; J Neely; J Kloeber; WE Lesuer; RS Pero; P Lacy; R Moqbel; NA Lee; JJ Lee
Journal of leukocyte biology, 2013 May 24. [Epub ahead of print]
Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
137. Glucose homeostasis in mice is transglutaminase 2 independent. (KI non-conditional)
SE Iismaa; M Aplin; S Holman; TW Yiu; K Jackson; JG Burchfield; CJ Mitchell; L O'Reilly; A Davenport; J Cantley; C Schmitz-Peiffer; TJ Biden; GJ Cooney; RM Graham
PloS one, 2013 May 22;8(5):e63346. doi: 10.1371/journal.pone.0063346.
Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.
138. Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation. (KO conditional)
A Pratama; RR Ramiscal; DG Silva; SK Das; V Athanasopoulos; J Fitch; NK Botelho; PP Chang; X Hu; JJ Hogan; P Maña; D Bernal; H Korner; D Yu; CC Goodnow; MC Cook; CG Vinuesa
Immunity, 2013 Apr 18;38(4):669-80. doi: 10.1016/j.immuni.2013.01.011.
John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.
139. Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering. (KI non-conditional)
J Vukovic; GG Borlikova; MJ Ruitenberg; GJ Robinson; RK Sullivan; TL Walker; PF Bartlett
The Journal of neuroscience : the official journal of the Society for Neuroscience, http://www.ncbi.nlm.nih.gov/pubmed/23575857
The University of Queensland, Brisbane, Queensland 4072, Australia.
140. Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type-Specific Functions of TLR4 during Sepsis. (KO conditional)
M Deng; MJ Scott; P Loughran; G Gibson; C Sodhi; S Watkins; D Hackam; TR Billiar
Journal of immunology (Baltimore, Md. : 1950), 2013 Apr 5. [Epub ahead of print]
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
141. Rgs13 constrains early B cell responses and limits germinal center sizes. (KO/KI)
IY Hwang; KS Hwang; C Park; KA Harrison; JH Kehrl
PloS one, 2013;8(3):e60139. doi: 10.1371/journal.pone.0060139. Epub 2013 Mar 22.
B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
142. Cellular specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury. (KO conditional)
GW Nace; H Huang; JR Klune; RE Eid; BR Rosborough; S Korff; S Li; RA Shapiro; DB Stolz; CP Sodhi; DJ Hackam; DA Geller; TR Billiar; A Tsung
Hepatology (Baltimore, Md.), 2013 Mar 4. doi: 10.1002/hep.26346. [Epub ahead of print]
Department of Surgery, University of Pittsburgh, Pittsburgh, PA.
143. Nitroxyl (HNO) Suppresses Vascular Nox2 Oxidase Activity. (KO conditional)
AA Miller; KF Maxwell; S Chrissobolis; ML Bullen; B Biomed; JM Ku; T Michael De Silva; S Selemidis; EU Hooker; GR Drummond; CG Sobey; BK Kemp-Harper
Free radical biology & medicine, 2013 Feb 28. pii: S0891-5849(13)00089-0. doi: 10.1016/j.freeradbiomed.2013.02.025. [Epub ahead of print]
Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University, Melbourne, VIC 3800, Australia.
144. TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. (KO conditional)
VW Tsai; L Macia; H Johnen; T Kuffner; R Manadhar; SB Jørgensen; KK Lee-Ng; HP Zhang; L Wu; CP Marquis; L Jiang; Y Husaini; S Lin; H Herzog; DA Brown; A Sainsbury; SN Breit
PloS one, 2013;8(2):e55174. doi: 10.1371/journal.pone.0055174. Epub 2013 Feb 28.
St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, New South Wales, Australia.
145. Dexras1, a Small GTPase, Is Required for Glutamate-NMDA Neurotoxicity. (KO conditional)
Y Chen; RS Khan; A Cwanger; Y Song; C Steenstra; S Bang; JH Cheah; J Dunaief; KS Shindler; SH Snyder; SF Kim
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013 Feb 20;33(8):3582-7. doi: 10.1523/JNEUROSCI.1497-12.2013.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
146. Pregnancy Associated Plasma Protein A2 (PAPP-A2) Affects Bone Size and Shape and Contributes to Natural Variation in Postnatal Growth in Mice. (KO conditional)
JK Christians; DR de Zwaan; SH Fung
PloS one, 2013;8(2):e56260. doi: 10.1371/journal.pone.0056260. Epub 2013 Feb 15.
Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
147. Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2. (KO conditional)
W Shi; AL Bain; B Schwer; F Al-Ejeh; C Smith; L Wong; H Chai; MS Miranda; U Ho; M Kawaguchi; Y Miura; JW Finnie; M Wall; J Heierhorst; C Wicking; KJ Spring; FW Alt; KK Khanna
PLoS genetics, 2013 Feb;9(2):e1003298. doi: 10.1371/journal.pgen.1003298. Epub 2013 Feb 7.
Queensland Institute of Medical Research, Herston, Australia.
148. Divergent effects of endogenous and exogenous GILZ in models of inflammation and arthritis. (KO conditional)
D Ngo; E Beaulieu; R Gu; A Leaney; L Santos; H Fan; Y Yang; W Kao; J Xu; V Escriou; S Loiler; MJ Vervoordeldonk; EF Morand
Arthritis and rheumatism, 2013 Jan 17. doi: 10.1002/art.37858. [Epub ahead of print]
Monash University, Clayton, Victoria, Australia.
149. Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo. (KI ROSA26)
JR Sundaram; CP Poore; NH Sulaimee; T Pareek; AB Asad; R Rajkumar; WF Cheong; MR Wenk; GS Dawe; KH Chuang; HC Pant; S Kesavapany
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013 Jan 2;33(1):334-343.
Department of Biochemistry, Centre for Life Sciences, National University of Singapore, 28 Medical Drive, #04-21, Singapore 117456.

2012

150. Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet. (KO conditional)
BK Cole; MA Morris; WJ Grzesik; KA Leone; JL Nadler
Mediators Inflamm., 2012;2012:851798. doi: 10.1155/2012/851798. Epub 2012 Dec 27.
Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
151. NLRX1 does not inhibit MAVS-dependent antiviral signalling. (KO conditional)
F Soares; I Tattoli; ME Wortzman; D Arnoult; DJ Philpott; SE Girardin
Innate immunity, 2012 Dec 4. [Epub ahead of print]
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
152. Human myo-inositol monophosphatase 2, rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. (KO conditional)
T Ohnishi; Y Tanizawa; A Watanabe; T Nakamura; H Ohba; H Hirata; C Kaneda; Y Iwayama; T Arimoto; K Watanabe; I Mori; T Yoshikawa
Journal of neurochemistry, 2012 Dec 4. doi: 10.1111/jnc.12112. [Epub ahead of print]
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan.
153. Generation of mice with a conditional null Fraser syndrome 1 (Fras1) allele. (KO conditional)
JE Pitera; M Turmaine; AS Woolf; PJ Scambler
Genesis, 2012 Dec;50(12):892-8. doi: 10.1002/dvg.22045.
Molecular Medicine Unit, Institute of Child Health, University College London, United Kingdom.
154. Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase. (KO conditional)
E Loyens; D De Bundel; H Demaegdt; SY Chai; P Vanderheyden; Y Michotte; P Gard; I Smolders
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2012 Nov 26:1-11. [Epub ahead of print]
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
155. Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity. (KI non-conditional)
M Espéli; MR Clatworthy; S Bökers; KE Lawlor; AJ Cutler; F Köntgen; PA Lyons; KG Smith
The Journal of experimental medicine, 2012 Nov 19;209(12):2307-19. doi: 10.1084/jem.20121752.
Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, England, UK.
156. Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. (KO conditional)
SK Drexler; L Bonsignore; M Masin; A Tardivel; R Jackstadt; H Hermeking; P Schneider; O Gross; J Tschopp; AS Yazdi
Proceedings of the National Academy of Sciences of the United States of America, 2012 Nov 6;109(45):18384-9. doi: 10.1073/pnas.1209171109.
Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.
157. Elimination of Germinal Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen. (KI ROSA26)
TD Chan; K Wood; JR Hermes; D Butt; CJ Jolly; A Basten; R Brink
Immunity, 2012 Nov 6. pii: S1074-7613(12)00462-1. doi: 10.1016/j.immuni.2012.07.017.
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.
158. A phenotype survey of thirty-six mutant mouse strains with gene targeted defects in glycosyltransferases or glycan-binding proteins. (KO conditional)
SL Orr; D Le; JM Long; P Sobieszczuk; B Ma; H Tian; X Fang; JC Paulson; JD Marth; N Varki
Glycobiology, 2012 Oct 31. [Epub ahead of print]
Department of Pathology, University of California, San Diego, La Jolla, CA 92093-0687, USA.
159. Genetic Deletion of RALA and RALB Small GTPases Reveals Redundant Functions in Development and Tumorigenesis. (Bruce4 ES cells)
P Peschard; A McCarthy; V Leblanc-Dominguez; M Yeo; S Guichard; G Stamp; CJ Marshall
Current biology : CB, 2012 Oct 9. pii: S0960-9822(12)01076-7.
Oncogene Team, Division of Cancer Biology, Institute of Cancer Research, London SW3 6JB, UK.
160. A2B Adenosine Receptor Expression by Myeloid Cells Is Proinflammatory in Murine Allergic-Airway Inflammation. (KO conditional)
BG Belikoff; LJ Vaickus; M Sitkovsky; DG Remick
Journal of immunology (Baltimore, Md. : 1950), 2012 Oct 1;189(7):3707-13.
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
161. Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion. (KO conditional)
S Ye; ZA Karim; R Al Hawas; JE Pessin; AH Filipovich; SW Whiteheart
Blood, 2012 Sep 20;120(12):2484-92. Epub 2012 Jul 5
Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA.
162. Intestinal epithelial toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. (KO conditional)
CP Sodhi; MD Neal; R Siggers; S Sho; C Ma; MF Branca; T Prindle; AM Russo; A Afrazi; M Good; R Brower-Sinning; B Firek; MJ Morowitz; JA Ozolek; GK Gittes; TR Billiar; DJ Hackam
Gastroenterology, 2012 Sep;143(3):708-718.e5. Epub 2012 Jul 13.
Division of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA.
163. The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. (KO conditional)
S Jurado; K Gleeson; K O'Donnell; DJ Izon; CR Walkley; A Strasser; DM Tarlinton; J Heierhorst
The Journal of experimental medicine, Aug 27;209(9):1629-39. Epub 2012 Aug 13.
St. Vincent's Institute of Medical Research, The University of Melbourne, Melbourne, Victoria 3052, Australia.
164. Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype. (KO non-conditional)
EE Norgett; ZJ Golder; B Lorente-Cánovas; N Ingham; KP Steel; FE Karet Frankl
Proceedings of the National Academy of Sciences of the United States of America, 2012 Aug 21;109(34):13775-80. Epub 2012 Aug 7
Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom.
165. Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling. (KO conditional)
RB Perry; E Doron-Mandel; E Iavnilovitch; I Rishal; SY Dagan; M Tsoory; G Coppola; MK McDonald; C Gomes; DH Geschwind; JL Twiss; A Yaron; M Fainzilber
Neuron, 2012 Jul 26;75(2):294-305
Weizmann Institute of Science, Rehovot 76100, Israel.
166. Redd1 Is a Novel Marker of Testis Development but Is Not Required for Normal Male Reproduction. (KO conditional)
AJ Notini; PJ McClive; SJ Meachem; JA van den Bergen; PS Western; SE Gustin; VR Harley; P Koopman; AH Sinclair
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation, 2012 Jul 11. [Epub ahead of print]
Murdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Vic., Australia.
167. Role of STAT1 in the breast. (KO non-conditional)
SG Bailey; MS Cragg; PA Townsend
JAKSTAT., 2012 Jul 1;1(3):197-9. doi: 10.4161/jkst.20967.
Cancer Sciences Unit; Cancer Research UK Centre; Faculty of Medicine; University of Southampton; Southampton General Hospital; Southampton, UK.
168. Mice Deficient in GEM GTPase Show Abnormal Glucose Homeostasis Due to Defects in Beta-Cell Calcium Handling. (KO conditional)
JE Gunton; M Sisavanh; RA Stokes; J Satin; LS Satin; M Zhang; SM Liu; W Cai; K Cheng; GJ Cooney; DR Laybutt; T So; JC Molero; ST Grey; DA Andres; MS Rolph; CR Mackay
PloS one, 2012;7(6):e39462. Epub 2012 Jun 28
Diabetes and Transcription Factors Group, Garvan Institute of Medical Research, Sydney, Australia.
169. Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria. (KO conditional)
IS Kil; SK Lee; KW Ryu; HA Woo; MC Hu; SH Bae; SG Rhee
Molecular cell, 2012 Jun 8;46(5):584-94.
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.
170. Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors. (KI conditional)
A Tikoo; V Roh; KG Montgomery; I Ivetac; P Waring; R Pelzer; L Hare; M Shackleton; P Humbert; WA Phillips
PloS one, 2012;7(5):e36924. doi: 10.1371/journal.pone.0036924. Epub 2012 May 30.
Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
171. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. (KO conditional)
KM Hinkle; M Yue; B Behrouz; JC Dachsel; SJ Lincoln; EE Bowles; JE Beevers; BN Dugger; CB Kent; B Winner; I Prots; K Nishioka; W Lin; DW Dickson; CG Janus; MJ Farrer; HL Melrose
Molecular neurodegeneration, 2012 May 30;7(1):25. [Epub ahead of print]
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA.
172. Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice. (KO conditional)
F Wiede; SH Chew; C van Vliet; IJ Poulton; K Kyparissoudis; T Sasmono; K Loh; ML Tremblay; DI Godfrey; NA Sims; T Tiganis
PloS one, 2012;7(5):e36703. Epub 2012 May 8
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
173. Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. (KO conditional)
Y Liu; FS Korte; F Moussavi-Harami; M Yu; M Razumova; M Regnier; MT Chin
American journal of physiology. Heart and circulatory physiology, 2012 May;302(9):H1860-70. Epub 2012 Mar 9.
Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington 98109, USA.
174. Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response. (KO conditional)
CM Fang; S Roy; E Nielsen; M Paul; R Maul; A Paun; F Koentgen; FM Raval; E Szomolanyi-Tsuda; PM Pitha
Genes and immunity, 2012 Apr 26. doi: 10.1038/gene.2012.10. [Epub ahead of print]
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
175. Methionine sulfoxide reductase contributes to meeting dietary methionine requirements. (KO conditional)
H Zhao; G Kim; RL Levine
Archives of biochemistry and biophysics, 2012 Apr 13;522(1):37-43. [Epub ahead of print]
Laboratory of Biochemistry, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
176. PORCN Moonlights in a Wnt-Independent Pathway That Regulates Cancer Cell Proliferation. (KO conditional)
TM Covey; S Kaur; T Tan Ong; KD Proffitt; Y Wu; P Tan; DM Virshup
PloS one, 2012;7(4):e34532. Epub 2012 Apr 11.
Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
177. Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice. (KO conditional)
V Pham; AL Albiston; CE Downes; CH Wong; S Diwakarla; L Ng; S Lee; PJ Crack; SY Chai
Journal of neurotrauma, 2012 Apr 10;29(6):1243-8. Epub 2011 Dec 5
Howard Florey Institute, Victoria, Australia.
178. Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo. (KO conditional)
L Bai; MG Constantinides; SY Thomas; R Reboulet; F Meng; F Koentgen; L Teyton; PB Savage; A Bendelac
Journal of immunology (Baltimore, Md. : 1950), 2012 Apr 1;188(7):3053-61. Epub 2012 Mar 5.
Committee on Immunology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.
179. NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells. (KO non-conditional)
F Staehli; K Ludigs; LX Heinz; Q Seguín-Estévez; I Ferrero; M Braun; K Schroder; M Rebsamen; A Tardivel; C Mattmann; HR Macdonald; P Romero; W Reith; G Guarda; J Tschopp
Journal of immunology (Baltimore, Md. : 1950), 2012 Apr 15;188(8):3820-8. Epub 2012 Mar 12.
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
180. IAPs limit activation of RIP kinases by TNF receptor 1 during development. (Double targeting)
M Moulin; H Anderton; AK Voss; T Thomas; WW Wong; A Bankovacki; R Feltham; D Chau; WD Cook; J Silke; DL Vaux
The EMBO journal, 2012 Feb 10. doi: 10.1038/emboj.2012.18. [Epub ahead of print]
La Trobe Institute for Molecular Science, La Trobe University, Victoria, Australia.
181. Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice. (KO conditional)
I Caminschi; D Vremec; F Ahmet; MH Lahoud; JA Villadangos; KM Murphy; WR Heath; K Shortman
Molecular immunology, 2012 Feb;50(1-2):9-17. Epub 2011 Dec 29
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
182. Alcohol and aldehyde dehydrogenases: Retinoid metabolic effects in mouse knockout models. (KO non-conditional)
S Kumar; LL Sandell; PA Trainor; F Koentgen; G Duester
Biochimica et biophysica acta, 2012 Jan;1821(1):198-205. Epub 2011 Apr 15.
Sanford-Burnham Medical Research Institute, Development and Aging Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
183. Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype. (KO conditional)
X Tang; L Tian; G Esteso; SC Choi; AD Barrow; M Colonna; F Borrego; JE Coligan
Journal of immunology (Baltimore, Md. : 1950), 2012 Jan 15;188(2):548-58. Epub 2011 Dec 7
Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
184. Microenvironmental regulation by fibrillin-1. (KO conditional)
G Sengle; K Tsutsui; DR Keene; SF Tufa; EJ Carlson; NL Charbonneau; RN Ono; T Sasaki; MK Wirtz; JR Samples; LI Fessler; JH Fessler; K Sekiguchi; SJ Hayflick; LY Sakai
PLoS genetics, 2012 Jan;8(1):e1002425. doi: 10.1371/journal.pgen.1002425. Epub 2012 Jan 5
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America.
185. An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice. (KI conditional)
KM Kinross; KG Montgomery; M Kleinschmidt; P Waring; I Ivetac; A Tikoo; M Saad; L Hare; V Roh; T Mantamadiotis; KE Sheppard; GL Ryland; IG Campbell; KL Gorringe; JG Christensen; C Cullinane; RJ Hicks; RB Pearson; RW Johnstone; GA McArthur; WA Phillips
The Journal of clinical investigation, 2012 Feb 1;122(2):553-7. doi: 10.1172/JCI59309. Epub 2012 Jan 3.
Cancer Research Division, Peter MacCallum Cancer Centre (Peter Mac), East Melbourne, Victoria, Australia.

2011

186. Regulation of the probability of mouse odorant receptor gene choice. (KO non-conditional)
M Khan; E Vaes; P Mombaerts
Cell, 2011 Nov 11;147(4):907-21
Max Planck Institute of Biophysics, 60438 Frankfurt, Germany.
187. Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures. (KO conditional)
E Loyens; A Schallier; SY Chai; D De Bundel; P Vanderheyden; Y Michotte; I Smolders
Seizure : the journal of the British Epilepsy Association, Oct;20(8):602-5. Epub 2011 May 25.
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
188. Analgesic Tolerance to High-Efficacy Agonists But Not to Morphine Is Diminished in Phosphorylation-Deficient S375A -Opioid Receptor Knock-In Mice. (KO/KI)
Grecksch G; Just S; Pierstorff C; Imhof AK; Glück L; Doll C; Lupp A; Becker A; Koch T; Stumm R; Höllt V; Schulz S
J Neurosci, 2011 Sep 28;31(39):13890-6
Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto-von-Guericke-University, D-39120 Magdeburg, Germany.
189. Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation (KO conditional)
Shimba S; Ogawa T; Hitosugi S; Ichihashi Y; Nakadaira Y; Kobayashi M; Tezuka M; Kosuge Y; Ishige K; Ito Y; Komiyama K; Okamatsu-Ogura Y; Kimura K; Saito M
PLoS One, 2011;6(9):e25231. Epub 2011 Sep 22.
Department of Health Science, School of Pharmacy, Nihon University, Funabashi, Chiba, Japan.
190. Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies (KO conditional)
Duysen, EG; Koentgen, F; Williams, GR; Timperley, CM; Schopfer, LM; Cerasoli, DM; Lockridge, O
Chem Res Toxicol, 2011 Sep 7. [Epub ahead of print]
Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-5950, USA.
191. AMP-activated protein kinase (AMPK) 12 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. (KO conditional)
O'Neill HM; Maarbjerg SJ; Crane JD; Jeppesen J; Jørgensen SB; Schertzer JD; Shyroka O; Kiens B; van Denderen BJ; Tarnopolsky MA; Kemp BE; Richter EA; Steinberg GR
Proc Natl Acad Sci U S A, 2011 Sep 6. [Epub ahead of print]
Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5.
192. Preclinical development of CAT-354, an IL-13-neutralising antibody, for the treatment of severe uncontrolled asthma. (KI non-conditional)
May, R; Monk, P; Cohen, E; Manuel, D; Dempsey, F; Davis, N; Dodd, A; Corkill, D; Woods, J; Joberty-Candotti, C; Conroy, L; Koentgen, F; Martin, E; Wilson, R; Brennan, N; Powell, J; Anderson, I.
Br J Pharmacol, 2011 Sep 6. doi: 10.1111/j.1476-5381.2011.01659.x. [Epub ahead of print]
MedImmune, Abington, Cambridge, UK.
193. Lung-specific loss of the laminin 3 subunit confers resistance to mechanical injury (KO conditional)
Urich, D; Eisenberg, JL; Hamill, KJ; Takawira, D; Chiarella, SE; Soberanes, S; Gonzalez, A; Koentgen, F; Manghi, T; Hopkinson, SB; Misharin, AV; Perlman, H; Mutlu, GM; Budinger, GR; Jones, JC
J Cell Sci, 2011 Sep 1;124(Pt 17):2927-37.
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
194. PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression (KO conditional)
Chi, Bun Chan; Chi, Wai Lee; Lin, Mei and Keqiang Ye; Xia, Liu; Xiaoling, Tang; Yongjun, Chen
EMBO J, 2011 Aug 16. doi: 10.1038/emboj.2011.281. [Epub ahead of print]
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
195. Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development. (KO/KI)
Ng, L; Lu, A; Swaroop, A; Sharlin, DS; Forrest, D.
J Neurosci, 2011 Aug 3;31(31):11118
NIDDK, Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892-1772, USA.
196. Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. (KO conditional)
Claudio, E; Cunningham, K; Li, W; Mukouyama, YS; O'Donnell, E; Siebenlist, U.; Soneji, K; Uchida, Y; Wang, H
Hum Mol Genet, 2011 Aug 15;20(16):3198-206. Epub 2011 May
Immune Activation Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
197. Human Cancer-Associated Mutations in A Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A Knock-in and Knockout Mice. (KO conditional)
Ruediger, R; Ruiz, J; Walter, G.
Mol Cell Biol, 2011 Sep;31(18):3832-44. Epub 2011 Jul
Department of Pathology, University of California at San Diego, La Jolla, CA 92093-0612, USA.
198. Evidence That Cd101 Is an Autoimmune Diabetes Gene in Nonobese Diabetic Mice. (KO conditional)
Bluestone, JA; Burren, O; Christensen, M; Clark, J; Finger, EB; Fraser, HI; Fusakio, ME; Houchins, JP; Howlett, SK; Koentgen, F; Masteller, EL; Mattner, J; Mohammed, JP; Moody, V; Moule, C; Naf, D; Peterson, LB; Rainbow, DB; Ridgway, WM; Steward, CA; Todd, JA; Wicker, LS
J Immunol, 2011 Jul 1;187(1):325-36. Epub 2011 May
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
199. Central nervous system dysfunction in a mouse model of FA2H deficiency. (KO conditional)
Bielawski, J; Cheng, H; Fullbright, G; Hama, H.; Han, X; Kern, MJ; Khan, PA; Li, JJ; Potter, KA; Rohrer, B; Scherer, SS; Venkata, JK; Yum, SW
GILA, 2011 Jul;59(7):1009-21. doi: 10.1002/glia.21172. Epub 2011 Apr
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
200. Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. (KO conditional)
An, J; Bun, Chan C; Hao, C; Liu, X; Luo, HR; Pradoldej, S; Ye, K.; Yepes, M
J Neurosci, 2011 Jun 1;31(22):8083
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
201. Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation. (KO/KI)
Gupta, M; He, JC; Li, Q; Lira, SA; Liu, J; Mayer, L; Morse, HC 3rd; Ning, H; Ouyang, X; Ozato, K; Qi, CF; Qin, L; Shin, MS; Xiong, H.; Yang, J; Zhang, R; Zhu, C
Nat Commun, 2011;2:314. doi: 10.1038/ncomms1311.
Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, New York 10029, USA.
202. Exploring phospholipase C-coupled Ca(2+) signalling networks using boolean modelling. (KO conditional)
Albert, R; Bhardwaj, G; Patterson, RL.; van, Rossum DB; Wells, CP
IET Syst Biol, 2011 May;5(3):174
The Pennsylvania State University, Department of Biology, University Park, PA 16801, USA.
203. Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. (KO non-conditional)
Boase, NA; Candi, E; Cook, DI; Dinudom, A; Koentgen, F; Kumar, S.; Melino, G; Rychkov, GY; Semsarian, C; Townley, SL; Tsoutsman, T; Voss, AK
Nat Commun, 2011;2:
Department of Haematology, Centre for Cancer Biology, SA Pathology, PO Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia.
204. Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: A study on the enzyme knockout mice. (KO conditional)
Cheng, Y; Duan, RD; Hansen, GH; Koentgen, F; Niels-Christiansen, LL; Nilsson, A; Ohlsson, L; Zhang, Y
J Lipid Research, 2011 Apr;52(4):771-81. Epub 2010 Dec
Gastroenterology and Nutrition Laboratory, Biomedical Center B11, Lund University, S-221 84 Lund, Sweden.
205. Adenosine Negative Feedback On A2A Adenosine Receptors Mediates Hypo-Responsiveness In Chronically Septic Mice (KO conditional)
Belikoff, B; Hatfield, S; Remick, DG.; Sitkovsky, M
Shock, 2011 Apr;35(4):38
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.
206. piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid Signaling (KO conditional)
Andrew, J. Morris; Hongmei, Ren; Huiyan, Huang; Krishna, Sarma; Michael, A. Frohman; Qun, Gao; Seok-Yong, Choi; Xiaoxue, Peng
Dev Cell, 2011 Mar 15;20(3):376
Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794-5140, USA.
207. The phosphoinositide kinase PIKfyve is vital in early embryonic development: Preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice (KI non-conditional)
Delvecchio, K; Ikonomov, OC; Jin, JP; Rappolee, D; Sbrissa, D; Shisheva, A.; Xie, Y
J Biol Chem, 2011 Apr 15;286(15):13404-13. Epub 2011 Feb
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
208. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response (Double targeting)
Anderton, H; Basten, A; Brink, R.; Gardam, S; Koentgen, F; Limaye, S; Silke, J; Turner, VM; Vaux, DL
Blood, 2011 Apr 14;117(15):4041-51. Epub 2011 Fe
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
209. Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase. (KO conditional)
Barrow, R; Cha, SH; Chakraborty, A; Juluri, KR; Kim, S; Kim, SF; Koldobskiy, MA3; Maag, D; Maxwell, MJ; Resnick, AC; Snowman, AM; Snyder, SH.
Cell Metab, 2011 Feb 2;13(2):215
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
210. IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools. (KO conditional)
Feng, J; Masiuk, M; Morse, HC 3rd.; Qi, CF; Shin, DM; Wang, H
J Immunol, 2011 Feb 1;186(3):1458-66. Epub 2010 Dec
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
211. Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB (KO conditional)
Boucher, KL; Choudhari, N; Hanno, AG; Hardesty, DA; Ma, JF; Maag, D; Maxwell, MJ; Pietropaoli, JW; Resnick, AC.; Saiardi, A; Snowman, AS; Snyder, SH.; Storm, PB; Xu, R
PNAS , 2011 Jan 25;108(4):1391-6. Epub 2011 Jan
The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
212. Vstm3 is a Member of the CD28 Family and an Important Modulator of T Cell Function (KO non-conditional)
Ardourel, D; Bilsborough, J; Blazar, BR; Bontadelli, K; Brandt, CS; Bucher, C; Bukowski, TR; Chadwick, EM; Fox, B; Gao, Z; Hammond, A; Hebb, L; Howard, ED; Johnston, J; Kuijper, JL; Levin, SD; Lewis, KE; Ostrander, CD; Ramsdell, F; Rixon, MW; Taft, DW; West, JW; Wolf, A; Xu, W
Euro J of Immunol, 2011 Apr;41(4):902-15. doi: 10.1002/eji.201041136. Epub 2011 Mar
Department of Immunology, ZymoGenetics, Inc., Seattle, WA, USA.
213. A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice. (KO conditional)
Belikoff, BG; Buras, JA; Georgiev, P; Hatfield, S; Lukashev, D; Ohta, A; Remick, DG; Sitkovsky, M.
J Immunol, 2011 Feb 15;186(4):2444-53. Epub 2011 Jan
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
214. Group V secretory phospholipase A2 plays a pathogenic role in myocardial ischaemia-reperfusion injury. (KO conditional)
Fujioka, D; Kawabata, K; Kobayashi, T; Kugiyama, K.; Mishina, H; Nakamura, T; Obata, JE; Saito, Y; Tamaru, S; Watanabe, K; Watanabe, Y; Yano, T
Cardiovasc Res, 2011 May 1;90(2):335-43. Epub 2010 Dec
Department of Internal Medicine II, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Yamanashi, Chuo 409-3898, Japan.
215. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. (KO/KI)
Brynedal, B; Hafler, JP; Joller, N; Kassam, N; Kuchroo, VK.; Levin, SD; Sharpe, AH; Spoerl, S
J Immunol, 2011 Feb 1;186(3):1338-42. Epub 2011 Ja
Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

2010

216. A comparative study of Lrrk2 function in primary neuronal cultures. (KO conditional)
JC Dächsel; B Behrouz; M Yue; JE Beevers; HL Melrose; MJ Farrer
Parkinsonism & related disorders, 2010 Dec;16(10):650-5. Epub 2010 Sep 17.
Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
217. Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK. (KO non-conditional)
YJ Chae; J Zhang; P Au; M Sabbadini; GX Xie; CS Yost
Anesthesiology, 2010 Dec;113(6):1326-37
Department of Anesthesia and Pain Medicine, Ajou University Medical Center, Suwon, Korea.
218. Whole-body deletion of AMPK 2 reduces muscle AMPK and exercise capacity. (KO conditional)
Campbell, DJ; Chen, ZP; Dzamko, NL; Galic, S; Hewitt, K; Honeyman, J; Jorgensen, SB; Kemp, BE.; Koentgen, F; Koopman, R; Lynch, GS; Naim, T; O'Neill, HM; Schertzer, JD; Scott, J; Steinberg, GR; Vandenderen, BJ; Watt, MJ
J Biol Chem, 2010 Nov 26;285(48):37198-209. Epub 2010 Sep
Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
219. microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. (KO conditional)
Cambronne, XA; Goodman, RH.; Leighton, BH; Lioy, DT; Luikart, BW; Magill, ST; Mandel, G; Westbrook, GL
PNAS, 2010 Nov 23;107(47):20382-7. Epub 2010 No
Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
220. The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. (KO conditional)
Pasquale, EB.; Roselli, S; Vervoort, V; Wallez, Y; Wang, L
Cell Signal, 2010 Nov;22(11):1745-52. Epub 2010 Jul
Sanford-Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA.
221. Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells. (KI non-conditional)
Cantrell, DA.; Emslie, E; Feijoo-Carnero, C; Matthews, SA; Navarro, MN; Sinclair, LV
Biochem J, 2010 Nov 15;432(1):153-63. doi: 10.1042/BJ20101188.
Ninewells Hospital, University of Dundee, Scotland, UK.
222. Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity. (Tg lentiviral)
KK Tam; DL Russell; DJ Peet; CP Bracken; RJ Rodgers; JG Thompson; KL Kind
Molecular and cellular endocrinology, 2010 Oct 7;327(1-2):47-55. Epub 2010 Jun 25.
The Robinson Institute, Research Centre for Reproductive Health, The University of Adelaide, South Australia, Australia.
223. The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. (KO conditional)
Coré, N; Cremer, H; Pasquale, EB.; Vervoort, V; Wallez, Y; Wang, L
J Neurosci, 2010 Sep 29;30(39):13201
Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.
224. Regional neural tube closure defined by the Grainy head-like transcription factors. (KO/KI)
Y Rifat; V Parekh; T Wilanowski; NR Hislop; A Auden; SB Ting; JM Cunningham; SM Jane
Developmental biology, 2010 Sep 15;345(2):237-45.
Melbourne Health Research Directorate, c/o Royal Melbourne Hospital Post Office, Parkville, VIC 3050, Australia.
225. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. (KI non-conditional)
Bey, AL; Bugge, TH.; Chavakis, T; Choi, EY; Connolly, BM; Currie, BM; Gårdsvoll, H; Leppla, SH; Liu, S; Molinolo, A; Ploug, M
Blood, 2010 Sep 2;116(9):1593-603. Epub 2010 May
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
226. In vivo studies of mutant fibrillin-1 microfibrils. (KI conditional)
Carlberg, VM; Carlson, EJ; Charbonneau, NL; Keene, DR; Manalo, EC; Ramirez, F; Sakai, LY.; Sengle, G; Tufa, S
J Biol Chem, 2010 Aug 6;285(32):24943-55. Epub 2010 Ju
Shriners Hospital for Children, Oregon Health & Science University, Portland, Oregon 97239, USA.
227. PNPASE regulates RNA import into mitochondria. (KO conditional)
Allen, EL; Chen, HW; Fan, KC; French, SW; Hong, JS; Koehler, CM; Lightowlers, RN; McCaffery, JM; Morse, HC 3rd; Oktay, Y; Smith, GM; Teitell, MA.; Wang, G; Zhang, J
Cell, 2010 Aug 6;142(3):456
Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA.
228. Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. (KO conditional)
Beck, H; Berkovic, SF; Cromer, BA; Davies, PJ; Hill, EL; Horstmann, MT; Leaw, BT; Lerche, H; Mitchell, S; Petrou, S.; Reid, CA; Richards, KL; Royeck, M; Scaf, BB; Wimmer, VC; Xu, R
J Clin Invest, 2010 Aug 2;120(8):2661-71. doi: 10.1172/JCI42219. Epub 2010 Jul
Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia.
229. S100A4 regulates macrophage chemotaxis (KO conditional)
Li ZH; Dulyaninova NG; House RP; Almo SC; Bresnick AR
Mol Biol Cell, 2010 Aug 1;21(15):2598-610. Epub 2010 Jun 2.
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
230. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. (KI non-conditional)
Bendor, J; Brandstetter, M; Flajolet, M; Greengard, P.; Hemmings, HC Jr; Lizardi-Ortiz, JE; Sulzer, D; Westphalen, RI
EMBO J, 2010 Aug 18;29(16):2813-26. Epub 2010 Jul
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065, USA.
231. Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice. (Tg pronuclear injection)
Aird, WC; Ballermann, BJ; Jahroudi, N.; Kulak, S; Liu, J; Nassiri, M; Uwiera, RR
Arterioscler Thromb Vasc Biol, 2010 Jul;30(7):1423-9. Epub 2010 Apr
University of Alberta, Edmonton, AL, Canada.
232. Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene, BORIS (KO/KI)
Abdullaev, Z; Kosaka-Suzuki, N; Lobanenkov, V.; Loukinov, D; Morse, HC 3rd; Pack, S; Pugacheva, E; Shin, DM; Suzuki, T; Yoon, J
Journal Mol Cell Biol, 2010 May;30(10):2473-84. Epub 2010 Mar
Laboratory of Immunopathology, National Institutes of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA.
233. c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway. (KI non-conditional)
Dagger, SA; Jansen, ES; Koentgen, F; Langdon, WY; Scott, CL; Steer, JH; Thien, CB
J Biol Chem, 2010 Apr 2;285(14):10969-81. Epub 2010 Fe
School of Pathology and Laboratory Medicine, University of Western Australia, Crawley 6009,Western Australia.
234. Expression of helios, an ikaros transcription factor family member, differentiates thymic-derived from peripherally induced foxp3+ T regulatory cells. (KO conditional)
Belkaid, Y; Korty, PE; Murray, PE; Shevach, EM.; Thornton, AM; Tran, DQ; Wohlfert, EA
J Immunol, 2010 Apr 1;184(7):3433-41. Epub 2010 Feb
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
235. Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. (Not categorised)
De, Silva TM; Diep, H; Drummond, GR; Judkins, CP; Miller, AA; Sobey, CG.
Stroke, 2010 Apr;41(4):784-9. Epub 2010 Feb
Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
236. Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. (KO conditional)
Chan, CB; Jun, JY; Jung, DY; Kim, JK; Liu, X; Luo, HR; Ye, K.
Diabetes, 2010 Apr;59(4):883-93. Epub 2010 Jan
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
237. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. (KO conditional)
Chan, CB; Dillehay, DL; Ensslin, MA; Liu, X; Ormandy, CJ; Serra, R; Sohn, P; Ye, K.
EMBO J, 2010 Mar 3;29(5):956-68. Epub 2010 Jan
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
238. Germline deletion of AMP-activated protein kinase subunits reduces bone mass without altering osteoclast differentiation or function. (KO conditional)
Gillespie, MT; Kemp, BE; McGregor, NE; Poulton, IJ; Quinn, JM; Saleh, H; Scott, JW; Sims, NA; Tam, S; van, Denderen BJ.
FASEB J, 2010 Jan;24(1):275-85. Epub 2009 Se
Prince Henry's Institute, Monash Medical Centre, Clayton, Australia.
239. Death-associated protein kinase-mediated cell death modulated by interaction with DANGER (KO conditional)
Ahmad, AS; Doré, S; Hester, L; Kang, BN; Patterson, RL; Saleem, S; Snyder, SH.
J Neuroscience, 2010 Jan 6;30(1):9
Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
240. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. (KO conditional)
Cooney, GJ; Furler, SM; Hegarty, BD; Hoehn, KL; Hoy, AJ; James, DE; Joshi, H; Kraegen, EW; Larance, M; Leslie, SJ; Phua, Y; Pickford, R; Preston, E; Swarbrick, MM; Turner, N; Wilks, D
Cell Metab, 2010 Jan;11(1):7
Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
241. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice (Not categorised)
Broughton, BR; Diep, H; Drummond, GR.; Dusting, GJ; Hooker, EU; Judkins, CP; Mast, AE; Miller, AA; Selemidis, S; Sobey, CG
Am J Physiol Heart Circ Physiol, 2010 Jan;298(1):H24-32. Epub 2009 Oct
Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
242. Engineering the mouse genome to model human disease for drug discovery. (Not categorised)
Koentgen, F; Naf, D.; Suess, G
Methods Mol Biol, 2010;602:55
Ozgene Pty Ltd, Bentley, WA, Australia.
243. Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory. (KO conditional)
Albiston, AL; Burns, P; Chai, SY.; Daswani, D; Diwakarla, S; Fernando, RN; Ng, L; Pham, V; Yeatman, HR
Neurobiol Learn Mem, 2010 Jan;93(1):19-30. Epub 2009 Au
University of Melbourne, Parkville, Victoria 3010, Australia.
244. Toll-like-receptor-4 Inhibits Enterocyte Proliferation via Impaired beta-catenin Signaling in Necrotizing Enterocolitis. (KO conditional)
Branca, M; Grant, ZS; Gribar, SC; Hackam, DJ.; Ma, C; Prindle, T Jr; Richardson, WM; Russo, A; Shapiro, RA; Shi, XH; Sodhi, CP
Gastroenterology, 2010 Jan;138(1):185-96. Epub 2009 Sep
Division of Pediatric Surgery, Department of Surgery, Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA.

2009

245. Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice. (KO conditional)
Albiston, AL; Burns, P; Chai, SY.; Diwakarla, S; Ng, L; Pham, V; Yeatman, HR
Peptides, 2009 Oct;30(10):1861-5. Epub 2009 Au
University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.
246. Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M. (KO conditional)
Bakker, ST; de, Winter JP.; Delzenne-Goette, E; Joenje, H; Oostra, AB; Rooimans, MA; Steltenpool, J; Te, Riele H; van, de Vrugt HJ; van, der Valk M; van, der Wal A
Hum Mol Genet, 2009 Sep 15;18(18):3484-95. Epub 2009 Jun
Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
247. Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses. (KO conditional)
Basten, A; Brink, R.; Gatto, D; Mackay, CR; Paus, D
Immunity, 2009 Aug 21;31(2):259-69. Epub 2009 Jul
Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
248. Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice. (KO/KI)
Hu, JC.; Hu, Y; Lertlam, R; Simmer, JP; Yamakoshi, Y
J Biol Chem, 2009 Jul 10;284(28):19110-21. Epub 2009 Ma
Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA.
249. A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice (KO/KI)
Wiebe, V; Adler, T; Aguilar, A; Arendt, T; Becker, L; Blass, T; Bolle, I; Brückner, M; Busch, DH; Calzada-Wack, J; Dalke, C; Ehrhardt, N; Enard, W; Favor, J; Fischer, J; Fisher, SE; Fuchs, H; Gailus-Durner, V; Gehre, S; Giger, T; Graw, J; Groszer, M; Hammerschmidt, K; Hans, W; Hölter, S; Hölzlwimmer, G; Hrabé, de Angelis M; Ivandic, B; Javaheri, A; Kalaydjiev, S; Kallnik, M; Kling, E; Klingenspor, M; Klopstock, T; Kunder, S; Mobrugger, I; Morgenstern, R; Müller, U; Naton, B; Nickel, B; Ollert, M; Pääbo, S.; Quintanilla-Martinez, L; Racz, I; Rathkolb, B; Rozman, J; Schreiweis, C; Schrewe, A; Schulz, H; Schwarz, J; Sohr, R; Somel, M; Winter, C; Wolf, E; Wurst, W; Zimmer, A
Cell, 2009 May 29;137(5):961
Max-Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany
250. Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. (KO/KI)
Atsumi, T; Chang, TH; Morse, HC 3rd; Ozato, K.; Wang, H; Yoshimi, R
J Immunol, 2009 Jun 15;182(12):7527
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
251. Probasin Promoter Driven Expression of ID1 Is not Sufficient for Carcinogenesis in Rodent Prostate. (Tg pronuclear injection)
Dong, Q.; Macleod, D; Salomon, R; Young, L; Yu, XL
J Histochem Cytochem, 2009 Jun;57(6):599-604. Epub 2009 Ma
Central Clinical School, The University of Sydney and Department of Endocrinology and Sydney Cancer Centre Royal Prince Alfred Hospital, New South Wales, Australia.
252. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. (KO conditional)
Fuss, I; Kitani, A; Meng, G; Strober, W.; Zhang, F
Immunity, 2009 Jun 19;30(6):860-74. Epub 2009 Ju
Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
253. Mice lacking the extracellular matrix protein WARP develop normally but have compromised peripheral nerve structure and function. (KO/KI)
Allen, JM; Bateman, JF.; Brachvogel, B; Fitzgerald, J; Hansen, U; Lamandé, SR; Rowley, L; Schlötzer-Schrehardt, U; Zamurs, L
J Biol Chem, 2009 May 1;284(18):12020-30. Epub 2009 Mar
Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia.
254. Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel co-localized with mGluR6 at mouse photoreceptor ribbon synapses. (KO/KI)
Brandstaetter, JH; Dearden, P; Koentgen, F; Maw, MA; Specht, D; Tom, Dieck S.; Turner, P; Wolfrum, U; Wu, SB
Invest Ophthalmol Vis Sci, 2009 Feb;50(2):505-15. Epub 2008 Oct
Department of Biology, Animal Physiology, University of Erlangen-Nuremberg, Erlangen, Germany.

2008

255. Testis Development, Fertility, and Survival in Ethanolamine Kinase 2-Deficient Mice. (KO conditional)
Gustin, SE; Harley, VR; Koopman, PA; McClive, PJ; Sinclair, AH.; Western, PS
Endocrinology, 2008 Dec;149(12):6176-86. Epub 2008 Aug
Murdoch Children's Research Institute, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.
256. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. (Bruce4 ES cells)
Basaraba, RJ; Bogdan, C; El, Kasmi KC; Fitzgerald, KA; Henao-Tamayo, M; Kanneganti, TD; Kaplan, G; König, T; Koo, MS; Murray, PJ.; Orme, IM; Pesce, JT; Qualls, JE; Schleicher, U; Smith, AM; Thompson, RW; Tuomanen, EI; Wynn, TA
Nat Immunol, 2008 Dec;9(12):1399-406. Epub 2008 No
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38015, USA.
257. Osteoclast inhibitory lectin (OCIL), an immune cell product that is required for normal bone physiology in vivo. (KO conditional)
Cipetic, M; Gillespie, MT.; Kartsogiannis, V; Ly, C; Martin, TJ; McGregor, NE; Ng, KW; Poulton, IJ; Quinn, JM; Saleh, H; Sims, NA; Smyth, MJ; Walker, EC; Wallace, ME; Zhou, H
J Biol Chem, 2008 Nov 7;283(45):30850-60. Epub 2008 Se
St. Vincent's Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia.
258. ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein. (KO conditional)
Bailey, SL; Chang, SC; Choo, KH; Earle, E; Graham, AN; Griffiths, B; Kalitsis, P.; Saffery, R
Chromosoma, 2008 Aug;117(4):367-80. Epub 2008 Mar
Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia.
259. Rat aquaporin-5 4.3-Kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. (Tg lentiviral)
Ann, D; Borok, Z.; Crandall, ED Ph D M D; Flodby, P; Liebler, JM; Minoo, P; Zhou, B
Am J Physiol Cell Physiol, 2008 Jul;295(1):C111-20. Epub 2008 Apr
Will Rogers Institute Pulmonary Research Center, Department of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
260. Conditional activation of a single-copy L1 transgene in mice by Cre. (KI conditional)
An, W; Boeke, JD.; Han, JS; Koentgen, F; Maitra, A; Schrum, CM
Genesis,
The High Throughput Biology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
261. The extracellular matrix protein WARP is a novel component of a distinct subset of basement membranes. (KO/KI)
Allen, JM; Bateman, JF.; Brachvogel, B; Farlie, PG; Fitzgerald, J
Matrix Biol, 2008 May;27(4):295-305. Epub 2008 Jan
Murdoch Childrens Research Institute, University of Melbourne, Royal Children's Hospital, Parkville, Victoria, Australia.
262. The murine stanniocalcin 2 gene is a negative regulator of post-natal growth. (Not categorised)
Chang, AC; Gunning, PW; Hardeman, EC; Hook, J; Lemckert, FA; Little, DG; McDonald, MM; Nguyen, MA; Reddel, RR.
Endocrinology, 2008 May;149(5):2403-10. Epub 2008 Fe
Cancer Research Unit, The Children's Hospital, Westmead, New South Wales 2145, Australia.
263. Enamel Defects and Ameloblast-specific Expression in Enam Knock-out/lacZ Knock-in Mice. (KO/KI)
Feng, JQ; Hu, JC; Hu, Y; Hunter, GK; McKee, MD; Papagerakis, P; Simmer, JP.; Smith, CE; Wright, JT; Yamakoshi, F; Yamakoshi, Y
J Biol Chem, 2008 Apr 18;283(16):10858-71. Epub 2008 Fe
Department of Orthodontics and Pediatric Dentistry and Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48108, USA.
264. Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. (Tg pronuclear injection)
Bonder, CS; Gamble, JR.; Hahn, CN; Li, X; Parsons, M; Pitson, SM; Proia, RL; Stankovic, M; Vadas, MA; Xia, P
Blood, 2008 Apr 1;111(7):3489-97. Epub 2008 Jan
Division of Human Immunology, Hanson Institute, Adelaide, Australia.
265. Distal cis-regulatory elements are required for tissue-specific expression of enamelin (Enam). (KO/KI)
Feng, JQ; Hu, JC.; Hu, Y; Papagerakis, P; Simmer, JP; Ye, L
Eur J Oral Sci, 2008 Apr;116(2):113
Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, Ann Arbor, MI 48108, USA.
266. Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. (KO conditional)
Asquith, S; Auden, A; Caddy, J; Cerruti, L; Cunningham, JM; Ellis, S; Hislop, NR; Jane, SM.; Sinclair, R; Ting, SB; Wilanowski, T; Zhao, LL
EMBO J, 2008 Mar 19;27(6):886-97. Epub 2008 Feb
Rotary Bone Marrow Research Laboratories, Melbourne Health Research Directorate, Royal Melbourne Hospital, Parkville, Victoria, Australia.
267. The Ets transcription factor Elf5 specifies mammary alveolar cell fate. (Tg pronuclear injection)
and, Ormandy C.; Asselin-Labat, M; Blazek, K; Chodosh, L; Gardiner-Garden, M; Hilton, H; Kazlauskas, M; Lindeman, G; Naylor, M; Oakes, R; Pfeffer, P; Pritchard, M; Visvader, J
Genes & Development, 2008 Mar 1;22(5):58
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
268. Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. (KO conditional)
Bhandari, R; Juluri, KR; Resnick, AC; Snyder, SH.
Proc Natl Acad Sci U S A, 2008 Feb 19;105(7):2349-53. Epub 2008 Feb
Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
269. An important role for type III Interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. (KO/KI)
Ank, N; Bartholdy, C; Chen, Z; Dagnaes-Hansen, F; Hartmann, R; Haugen, H; Iversen, MB; Jensen, UB; Klucher, K; Paludan, SR; Staeheli, P; Thomsen, AR
J Immunol, 2008 Feb 15;180(4):2474
Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark.
270. Anoikis effector Bit1 negatively regulates Erk activity. (KO conditional)
Besch-Williford, C; Biliran, H; Kairouz-Wahbe, R; Khor, I; Luo, X; Oshima, R; Pascual, J; Ruoslahti, E.; Wankell, M
Proc Natl Acad Sci U S A, 2008 Feb 5;105(5):1528-32. Epub 2008 Jan
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
271. Sequences in intron 51 of the von Willebrand factor gene target promoter activation to a subset of lung endothelial cells in transgenic mice. (Tg pronuclear injection)
Jahroudi, N.; Kleinschmidt, AM; Nassiri, M; Pitt, BR; Stitt, MS; Wasserloos, K; Watkins, SC
J Biol Chem, 2008 Feb 1;283(5):2741-50. Epub 2007 Nov
Biology Department, Allegheny College, Meadville, PA 16335, USA.
272. The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells. (KI non-conditional)
Dagger, SA; Langdon, WY.; Oksvold, MP; Thien, CB
Mol Immunol, 2008 Feb;45(4):925-36. Epub 2007 Sep
School of Surgery and Pathology, University of Western Australia, Crawley, Western Australia 6009, Australia.

2007

273. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. (Not categorised)
Ahmed, AU; Benetatos, CA; Brink, R; Callus, BA; Chau, D; Chunduru, SK; Condon, SM; Feltham, R; Khan, N; Koentgen, F; Leverkus, M; McKinlay, M; Schneider, P; Silke, J.; Tergaonkar, V; Vaux, DL; Vince, JE; Wong, WW
Cell, 2007 Nov 16;131(4):682
La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia.
274. NOTCH1 pathway activation is an early hallmark of SCL T-leukemogenesis. (KO conditional)
Begley, CG.; Brake, RL; Duhrsen, U; Gothert, JR; Izon, DJ.; Smeets, M
Blood, 2007 Nov 15;110(10):3753-62. Epub 2007 Aug
Department of Hematology, University Hospital, Essen, Germany.
275. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. (KO conditional)
Batten, M; Biben, C; Groom, J; Harvey, RP; Leung, H; Li, M; Mackay, CR; Mackay, F.; Martínez-A, C; Martínez-Muñoz, L; Mellado, M; Ransohoff, RM; Sierro, F; Woehl, B
Proc Natl Acad Sci U S A, 2007 Sep 11;104(37):14759-64. Epub 2007 Se
Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia.
276. Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. (KI non-conditional)
Farmer, PJ; Fosang, AJ.; Golub, SB; Lawlor, KE; Little, CB; Meeker, CT; Smith, SM
J Clin Invest, 2007 Jun;117(6):1627-36. Epub 2007 May
Arthritis Research Group, University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
277. Temporal regulation of Cre-recombinase activity in Scl-positive neurons of the central nervous system. (KO/KI)
Begley, CG.; Bradley, CK; Göthert, JR; Göttgens, B; Green, AR; Takano, EA; van, Eekelen JA.
Genesis, 2007 Mar;45(3):145
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Subiaco, Western Australia, Australia.
278. Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro. (KO conditional)
Bouralexis, S; Cipetic, M; Gillespie, MT; Kartsogiannis, V; Ly, C; Martin, TJ; Nakamura, A; Ng, KW; Price, JT; Quinn, JM.; Saleh, H; Sims, NA; Vieusseux, J; Zhou, H
Bone, 2007 Feb;40(2):305-15. Epub 2006 Oct
St. Vincent's Institute, 9, Princes Street, Fitzroy, Victoria, Australia.

2006

279. Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action. (KI non-conditional)
Cooney, GJ.; James, DE; Langdon, WY; Molero, JC; Thien, CB; Turner, N
Diabetes, 2006 Dec;55(12):341
Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia.
280. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. (KO conditional)
Andersen, B.; Bhandari, A; Gill, GN; Lin, KK; Lu, Z; Roop, DR; Spencer, JA; Wang, N; Wertz, P; Xu, X; Yu, Z
Dev Biol, 2006 Nov 1;299(1):122-36. Epub 2006 Jul
Departments of Medicine and Biological Chemistry, University of California, Irvine, CA 92697-4030, USA.
281. A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent. (Tg pronuclear injection)
Dunham, M; Koentgen, F; Lake, RA.; Robinson, BW; Robinson, C; Segal, A; Sherwood, A; van, Bruggen I
Cancer Res, 2006 Nov 15;66(22):10786
School of Medicine and Pharmacology and Western Australian Institute for Medical Research, University of Western Australia, Perth, Australia.
282. Renin enhancer is critical for control of renin gene expression and cardiovascular function. (KO non-conditional)
Adams, DJ; Arends, MJ; Head, GA; Kontgen, F; Lovicu, FJ; Markus, MA; Mayorov, DN; Morris, BJ.; Thiru, S; van, der Weyden L
J Biol Chem, 2006 Oct 20;281(42):31753-61. Epub 2006 Au
School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia.
283. Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies (KI non-conditional)
Lee, H; Mackay, CR.; Mackay, F; Newton, R; Padkjaer, SB; Quan, A; So, T; Thatcher, J; Vogelzang, A; Whitfeld, PL; Zahra, D; Zwirner J,Koentgen F
Nature Biotechnology, 2006 Oct;24(10):1279-84. Epub 2006 Sep
Immunology and Inflammation Department, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.
284. Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. (KO conditional)
Brehm, MA; Rock, KL.; Towne, CF; York, IA; Zendzian, S
Proc Natl Acad Sci U S A, 2006 Jun 13;103(24):9202-7. Epub 2006 Ju
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
285. Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis. (Tg pronuclear injection)
Andrikopoulos, S.; Fam, BC; Favaloro, J; Kebede, M; Lamont, BJ; Massinet, H; Papapostolou, S; Proietto, J; Visinoni, S; Weinrich, B
Endocrinology, 2006 Jun;147(6):2764-72. Epub 2006 Feb
Department of Medicine (Austin Health and Northern Health), University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria 3081, Australia.
286. Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. (KO/KI)
Alexander, WS.; Binder, MD; Butzkueven, H; Cate, HS; Cooper, H; Croker, B; Emery, B; Kilpatrick, TJ.; Marriott, M; Merson, T; Murray, S; Snell, C; Soo, PY; Zhang, JG
Proc Natl Acad Sci U S A, 2006 May 16;103(20):7859-64. Epub 2006 Ma
Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
287. Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. (KO non-conditional)
Kulkarni, AB; Leppla, SH.; Liu, S; Sreenath, T; Ward, JM; Wiggins, JF
Mol Cell Biol, 2006 May;26(10):3835
Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
288. Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning. (KO conditional)
Duester, G.; Molotkov, A; Molotkova, N
Development, 2006 May;133(10):1901-10. Epub 2006 Apr
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
289. Gout-associated uric acid crystals activate the NALP3 inflammasome. (KO/KI)
Martinon, F; Mayor, A; Petrilli, V; Tardivel, A; Tschopp, J.
Nature, 2006 Mar 9;440(7081):237-41. Epub 2006 Jan
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.

2005

290. The murine stanniocalcin 1 gene is not essential for growth and development. (KO conditional)
Cha, J; Chang, AC; Koentgen F,Reddel RR.
Mol Cell Biol, 2005 Dec;25(23):10604
Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia.
291. Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. (KI non-conditional)
Andoniou, CE; Blystad, FD; Langdon, WY; Lew, AM; Thien, CB; Voigt, V; Zhan, Y
EMBO J, 2005 Nov 2;24(21):3807-19. Epub 2005 Oc
School of Surgery and Pathology, University of Western Australia, Crawley, Australia.
292. Generation of transgenic mice with mild and severe retinal neovascularisation. (Not categorised)
Beazley, LD; Binz, N; Brankov, M; Constable, IJ; Dunlop, SA; Gorbatov, M; Graham CE,Barry CJ; Lai, CM; Lai, YK; May, LA; Rakoczy, EP.; Shen, WY
Br J Ophthalmol, 2005 Jul;89(7):91
Centre for Ophthalmology and Visual Science, The University of Western Australia, Nedlands, Australia.
293. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation (KO conditional)
Brian, L. Black; Christiana, Leimena; Christine, Biben; David, E. Elliott; David, J. McCulley; Diane, Fatkin and Richard P. Harvey; Donna, Lai; Fiona, A. Stennard; Jost, I. Preis; Mark, J. Solloway; Mauro, W. Costa; Milena, B. Furtado; Owen, W. J. Prall; Sally, L. Dunwoodie
Development, 2005 May;132(10):2451-62. Epub 2005 Apr
Victor Chang Cardiac Research Institute, St Vincent's Hospital, 384 Victoria Street, Darlinghurst 2010, New South Wales, Australia.
294. A homolog of Drosophila grainy head is essential for epidermal integrity in mice. (KO/KI)
Auden, A; Caddy, J; Cunningham, JM; Elias, PM; Ellis, S; Hislop, N; Holleran, WM; Jane, SM.; Kaur, P; Ting, SB; Uchida, Y; Wilanowski, T; Zhao, LL
Science, 2005 Apr 15;308(5720):41
Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050.
295. In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. (KI non-conditional)
Begley, CG.; Gothert, JR; Gottgens, B; Green, AR; Gustin, SE; Hall, MA; Izon, DJ
Blood, 2005 Apr 1;105(7):2724-32. Epub 2004 Dec
Division of Cancer Biology, Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, West Perth, Australia.
296. Lentiviral vector-based models of amyloid pathology: from cells to animals. (Tg lentiviral)

Current Alzheimer Research, 2005 Apr;2(2):239
Tranzyme Pharma Inc., 21 Davis Drive, Research Triangle Park, NC 27709, USA.
297. Matrix Metalloproteinases Are Not Essential for Aggrecan Turnover during Normal Skeletal Growth and Development. (KI non-conditional)
Fosang, AJ.; Golub, SB; Hembry, RM; Last, K; Lawlor, KE; Little, CB; Meeker, CT; Sims, NA
Mol Cell Biol, 2005 Apr;25(8):3388
Arthritis Research Group, University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville 3052, Australia.

2004

298. Human growth hormone presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejection. (Not categorised)
De, Kluyver R; Fernando, GJ; Frazer, IH.; Leggatt, GR; Matsumoto, K; Zhong, J
Immunol Cell Biol, 2004 Dec;82(6):577
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
299. Genetically tagging endothelial cells in vivo: bone marrow derived cells do not contribute toal Growth and Development. (Tg pronuclear injection)
Begley, CG.; Gothert, JR; Gottgens, B; Gustin, SE; Hall, MA; Izon, DJ; Jane, SM; Schmidt, U
Blood, 2004 Sep 15;104(6):1769-77. Epub 2004 Ju
Division of Cancer Biology, Telethon Institute for Child Health Research, Centre for Child Health Research and Western Australian Institute for Medical Research, University of Western Australia, West Perth, Australia.
300. The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal (KO non-conditional)
Beales, M; Böse, J; Gruber, AD; Hafner, M; Helming, L; Koentgen, F; Lengeling, A.; Schiebe, S; Wegener, I
J Biol, 2004;3(4):15. Epub 2004 Aug
German Research Center for Biotechnology (GBF), 38124 Braunschweig, Germany.
301. Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. (KO non-conditional)
Biben, C; Dunwoodie, SL; Henderson, MJ; Hird, SL; Ormandy, CJ; Saunders, DN; Sutherland, RL; Watts, CK.; Withington, SL
Mol Cell Biol, 2004 Aug;24(16):7225
Cancer Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst, 2010 NSW, Australia.
302. Novel approaches to models of Alzheimer's disease pathology for drug screening and development. (Tg lentiviral)
Chamblin, B; Koentgen, F; McMahon, L; Nair, A; Ramabhadran, R.; Shaughnessy, L; Thomas, MB; Wakefield, J
J Mol Neurosci, 2004;24(1):23
Tranzyme, Inc., Research Triangle Park, NC 27709, USA.
303. The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. (Bruce4 ES cells)
Barton, LM; Begley, CG.; Broccardo, C; Delaney, L; Deveaux, S; Erber, WN; Frampton, J; Gothert, JR; Gottgens, B; Green, AR.; Kinston, S; Knezevic, K; Kotsopoulou, E; Murphy, G; Piltz, S; Sanchez, MJ
Mol Cell Biol, 2004 Mar;24(5):1870
Department of Hematology, Cambridge Institute for Medical Research, University of Cambridge, United Kingdom.
304. All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain. (KO non-conditional)
Corcoran, LM; Dietrich, W; Humbert, PO.; Koentgen, F; Veale, M
J Immunol, 2004 Mar 1;172(5):296
The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.

2003

305. The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice. (KO conditional)
Barnett, L; Bernard, CC; Chow, AM; Clavarino, C; Freire, Garabal M; Goodyear, M; Huntington, ND; Koentgen, F; Linares, D; Mana, P; Reid, HH.; Tomioka, R
J Autoimmun, 2003 Dec;21(4):339
La Trobe University, Bundoora, Vic 3086, Australia.
306. Inositol and folate resistant neural tube defects in mice lacking the epithelial specific factor Grhl 3. (KO/KI)
Auden, A; Cunningham, JM; Hall, M; Jane, SM.; Parekh, V; Thomas, T; Ting, SB; Voss, AK; Wilanowski, T
Nat Med, 2003 Dec;9(12):1513-9. Epub 2003 No
Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050.
307. Role of the polymeric Ig receptor in mucosal B cell homeostasis. (KO non-conditional)
Brandtzaeg, P; Johansen, FE; Koentgen, F; Strugnell, RA.; Uren, TK; Wijburg, OL
J Immunol, 2003 Mar 1;170(5):253
Department of Microbiology and Immunology and Cooperative Research Center for Vaccine Technology, University of Melbourne, Parkville, Australia.
308. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU S12. (Not categorised)
Begley, CG.; Curtis, DJ; Elefanty, AG; Gothert, JR; Hall, MA; Jane, SM; Metcalf, D; Robb, L; Sourris, K
Proc Natl Acad Sci U S A,
Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia.

2002

309. Impaired cardiac contractility response to hemodynamic stress in S100A1 deficient mice. (KI non-conditional)
Cole, TJ; Du, XJ; Gao, XM; Heierhorst, J.; Kemp, BE; Kontgen, F; Tenis, N
Mol Cell Biol, 2002 Apr;22(8):282
Baker Medical Research Institute, Melbourne, Victoria
310. FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. (Not categorised)
Barnes, N; Gavin, AL; Hogarth, PM.; Koentgen, F; Mottram, P; Tan, PS
Immunity, 2002 Mar;16(3):379
Kronheimer Building, Studley Road, Heidelberg, Victoria 3084, Australia.
311. A 320 kilobase artificial chromosome encoding the human HLA DR3 DQ2 MHC haplotype confers HLA restriction in transgenic mice. (Not categorised)
Brown, L; Chen, Z; Deliyannis, G; Dudek, N; Gordon, T; Jackson, D; Koentgen, F; McCluskey, J.; Strugnell, R; Wijburg, O
J Immunol, 2002 Mar 15;168(6):305
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.
312. Essential role for the lymphostromal plasma membrane Ly 6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland. (KO non-conditional)
Barnett, L; Berzins, SP; Boyd, RL; Classon, BJ.; Gill, JW; Harvey, RP; Koentgen, F; Lambert, GW; Randle, Barrett ES; Zammit, DJ
Mol Cell Biol, 2002 Feb;22(3):946
Department of Pathology and Immunology, Monash Medical School, Prahran, Victoria, Australia.
313. Efficient Cre mediated deletion in cardiac progenitor cells conferred by a 3'UTR ires Cre allele of the homeobox gene Nkx2 5. (KO/KI)
Barnett, L; Biben, C; Elefanty, A; Harvey, RP.; Koentgen, F; Robb, L; Stanley, EG
Int J Dev Biol, 2002;46(4):43
Victor Chang Cardiac Research Institute, St Vincent's Hospital, Darlinghurst, NSW, Australia.

2001

314. Molecular cloning of F4/80 like receptor, a seven span membrane protein expressed differentially by dendritic cell and monocyte macrophage subpopulations. (Not categorised)
Caminschi, I; Hochrein, H; Kontgen, F; Laabi, Y; Lew, AM; Lucas, KM; O'Keeffe, MA; Shortman, K; Wright, MD.
J Immunol, 2001 Oct 1;167(7):357
Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia.
315. The small muscle specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin like growth factor 1 dependent manner. (Not categorised)
Barnett, L; Biben, C; Copeland, NG; Groves, N; Harvey, RP.; Jenkins, NA; Koentgen, F; Mohun, T; Palmer, S; Schindeler, A; Sparrow, DB; Wang, CC; Yeoh, T
J Cell Biol, 2001 May 28;153(5):985
Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.
316. Impaired thrombin generation in beta 2-glycoprotein I null mice. (Not categorised)
Y Sheng; SW Reddel; H Herzog; YX Wang; T Brighton; MP France; SA Robertson; SA Krilis
The Journal of biological chemistry, 2001 Apr 27;276(17):13817-21. Epub 2001 Jan 5.
Department of Medicine and the Department of Immunology, Allergy, and Infectious Disease, University of New South Wales, The St. George Hospital, Sydney, New South Wales 2217, Australia.
317. Gene targeting in a centralized facility. (Not categorised)
Barnett, LD; Kontgen, F
Methods Mol Biol, 2001;158:65
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

2000

318. Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2 5. (KO non-conditional)
Barnett, L; Biben, C; Elliott, DA; Feneley, M; Harvey, RP.; Kesteven, S; Koentgen, F; McDonald, L; Robb, L; Stanley, E; Weber, R
Circ Res, 2000 Nov 10;87(10):888
Victor Chang Cardiac Research Institute, Darlinghurst, Australia.
319. Homeodomain factor Nkx2 3 controls regional expression of leukocyte homing coreceptor MAdCAM 1 in specialized endothelial cells of the viscera. (KO conditional)
Barnett, L; Biben, C; Davidson, NO; Harvey, RP.; Koentgen, F; Nassir, F; Robb, L; Tarlinton, D; Wang, CC
Dev Biol, 2000 Aug 15;224(2):152
Victor Chang Cardiac Research Institute, St. Vincent's Hospital, Darlinghurst, Australia.
320. Gigantism in mice lacking suppressor of cytokine signalling 2. (Not categorised)
Alexander, WS.; Greenhalgh, CJ; Hilton, DJ; Metcalf, D; Nicola, NA; Starr, R; Viney, E; Willson, TA
Nature, 2000 Jun 29;405(6790):1069
The Walter and Eliza Hall Institute of Medical Research and The Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia.
321. Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis. (KO/KI)
Allison, J; Barnett, L; Biben, C; Campbell, IK; Hartley, L; Harvey, RP.; Koentgen, F; McKinley, M; Robb, L; Stanley, EG; Wicks, IP
Genesis, 2000 Apr;26(4):259

1999

322. Proapoptotic Bcl 2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. (Not categorised)
Adams, JM; Bouillet, P; Huang, DC; Kay, TW; Kontgen, F; Metcalf, D; Strasser, A.; Tarlinton, DM
Science, 1999 Nov 26;286(5445):173
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.
323. A direct method for the formation of peptide and carbohydrate dendrimers. (Not categorised)
Koentgen, F; Lambert, JN.; Langley, J; Mitchell, JP; Roberts, KD
Bioorg Med Chem Lett, 1999 Oct 4;9(19):278
School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia.

1998

324. EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. (KO non-conditional)
Bartlett, PF; Boyd, AW.; Dottori, M; Galea, M; Hartley, L; Kilpatrick, T; Kontgen, F; Murphy, M; Paxinos, G; Polizzotto, M
Proc Natl Acad Sci U S A, 1998 Oct 27;95(22):13248
Royal Brisbane Hospital, Herston, Queensland 4029, Australia.
325. Apoptosis regulator bcl w is essential for spermatogenesis but appears otherwise redundant. (KO non-conditional)
Adams, JM; Cory, S.; de, Kretser D; Gibson, L; Kontgen, F; Loveland, KL; Meehan, T; Metcalf, D; Print, CG; Stylianou, A; Wreford, N
Proc Natl Acad Sci U S A, 1998 Oct 13;95(21):12424
Post Office, Royal Melbourne Hospital, Victoria 3050, Australia.
326. Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock in" strategy. (KI non-conditional)
Barnett, L; Begley, CG.; Elefanty, AG; Kontgen, F; Metcalf, D; Robb, L.
Proc Natl Acad Sci U S A, 1998 Sep 29;95(20):11897-
Royal Melbourne Hospital, Victoria 3050, Australia.
327. Major histocompatibility complex class II expression by intrinsic renal cells is required for crescentic glomerulonephritis. (Not categorised)
Holdsworth, SR; Kontgen, F; Kurts, C; Li, S; Tipping, PG.
J Exp Med, 1998 Aug 3;188(3):597-
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, 3168, Victoria, Australia.
328. Induction of acute inflammation in vivo by staphylococcal superantigens I: Leukocyte recruitment occurs independently of T lymphocytes and major histocompatibility complex Class II molecules. (Not categorised)
Diener, K; Fraser, J; Kontgen, F; McColl, SR.; Tessier, P
Lab Invest, 1998 Jun;78(6):647
Department of Microbiology and Immunology, University of Adelaide, South Australia, Australia.
329. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. (KO non-conditional)
Begley, CG.; Hartley, L; Koentgen, F; Li, R; Nandurkar, HH; Robb, L
Nat Med, 1998 Mar;4(3):30
Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Victoria, Australia.

1997

330. Distinct roles for lymphotoxin alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. (KO non-conditional)
Cook, M; Fazekas, de St Groth B; Hoek, RM; Kontgen, F; Korner, H; Ledermann, B; Lemckert, FA; Riminton, DS; Sedgwick, JD.
Eur J Immunol, 1997 Oct;27(10):260
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia.
331. Adult mice with targeted mutation of the interleukin 11 receptor (IL11Ra) display normal hematopoiesis. (KO non-conditional)
Barnett, L; Begley, CG.; Kontgen, F; Nandurkar, HH; Robb, L; Tarlinton, D
Blood, 1997 Sep 15;90(6):2148
The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Victoria, Australia.
332. The role of leukemia inhibitory factor in skeletal muscle regeneration. (KO non-conditional)
Austin, L.; Bower, JJ; Koentgen, F; Kurek, JB; Murphy, M; Romanella, M
Muscle Nerve, 1997 Jul;20(7):815
Melbourne Neuromuscular Research Centre, St. Vincent's Hospital, Fitzroy, Melbourne, Australia.
333. Homeosis and intestinal tumours in Cdx2 mutant mice. (KO non-conditional)
Beck, F.; Chawengsaksophak, K; Hammond, VE; James, R; Kontgen, F
Nature, 1997 Mar 6;386(6620):8
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

1996

334. The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. (KO non-conditional)
Barnett, LD; Begley, CG.; Elefanty, AG; Elwood, NJ; Kontgen, F; Li, R; Robb, L
EMBO J, 1996 Aug 15;15(16):412
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
335. Resistance to endotoxin shock and reduced dissemination of gram negative bacteria in CD14 deficient mice. (KO non-conditional)
Ferrero, E; Goyert, SM.; Haziot, A; Hijiya, N; Kontgen, F; Silver, J; Stewart, CL; Yamamoto, S
Immunity, 1996 Apr;4(4):407
Division of Molecular Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030, USA.

1995

336. Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte macrophage colony stimulating factor and interleukins 3 and 5. (KO non-conditional)
Begley, CG.; Drinkwater, CC; Kontgen, F; Li, R; Metcalf, D; Nicola, NA; Robb, L
Proc Natl Acad Sci U S A, 1995 Oct 10;92(21):956
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
337. Mice lacking the c rel proto oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin 2 expression. (KO non-conditional)
Gerondakis, S.; Grumont, RJ; Kontgen, F; Li, R; Metcalf, D; Strasser, A; Tarlinton, D
Genes Dev, 1995 Aug 15;9(16):1965
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
338. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. (KO non-conditional)
Begley, CG.; Hartley, L; Harvey, RP; Kontgen, F; Li, R; Lyons, I; Metcalf, D; Robb, L
Proc Natl Acad Sci U S A, 1995 Jul 18;92(15):707
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
339. Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes. (Not categorised)
Carbone, FR; Heath, W; Kontgen, F; Lundberg, K; Shortman, K.
J Exp Med, 1995 May 1;181(5):1643
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
340. Creation and characterization of E selectin and VCAM 1 deficient mice. (KO non-conditional)
Burns, DK; et, al.; Kontgen, F; Kwee, L; Lombard, Gillooly KM; Norton, C; Rumberger, JM; Shuster, DJ; Stewart, C; Terry, R; Wolitzky, B
Ciba Found Symp, 1995;189:17-28; discussion 28-34, 7
Roche Research Center, Department of Biotechnology, Hoffman-La Roche Inc., Nutley, NJ 07110-1199, USA.

1994

341. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. (KO non-conditional)
MA Labow; CR Norton; JM Rumberger; KM Lombard-Gillooly; DJ Shuster; J Hubbard; R Bertko; PA Knaack; RW Terry; MJ Harbison; F Kontgen; CL Stewart; KW McIntyre; PC Will; DK Burns; BA Wolitzky
Immunity., 1994 Nov;1(8):709-20.
Roche Research Center, Hoffmann-La Roche, Incorporated, New Jersey 07110-1199, USA.

1993

342. T cell development in mice lacking the CD3 zeta/eta gene. (KO non-conditional)
Boyer, C; Brun, N; et, al.; Gillet, A; Kontgen, F; Malissen, M; Mazza, G; Rocha, B; Spanopoulou, E; Trucy, J; Vivier, E
EMBO J, 1993 Nov;12(11):4347
Marseille-Luminy, France.
343. Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. (KO conditional)
Kontgen, F; Suss, G; Stewart, C; Steinmetz, M; Bluethmann, H.
Int Immunol, 1993 Aug;5(8):957
Department of Biology, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
344. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF mediated toxicity but highly susceptible to infection by Listeria monocytogenes. (KO non-conditional)
Althage, A; Bluethmann, H.; Koebel, P; Kontgen, F; Lang, Y; Lesslauer, W; Lotscher, H; Rothe, J; Steinmetz, M; Zinkernagel, R
Nature, 1993 Aug 26;364(6440):798-
Department of Biology, Hoffmann-La Roche Ltd, Basel, Switzerland.
345. Simple screening procedure to detect gene targeting events in embryonic stem cells. (Not categorised)
Kontgen, F; Stewart, CL.
Methods Enzymol, 1993;225:878
Cellular Immunology Unit, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.

1992

346. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. (KO non-conditional)
Stewart, CL; Kaspar, P; Brunet, LJ; Bhatt, H; Gadi, I; Kontgen, F; Abbondanzo, SJ.
Nature, 1992 Sep 3;359(6390):7
Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110.

346 Publication(s)