J Immunol 2011 Jul 1;187(1):325-36. Epub 2011 May
Bluestone, JA; Burren, O; Christensen, M; Clark, J; Finger, EB; Fraser, HI; Fusakio, ME; Houchins, JP; Howlett, SK; Koentgen, F; Masteller, EL; Mattner, J; Mohammed, JP; Moody, V; Moule, C; Naf, D; Peterson, LB; Rainbow, DB; Ridgway, WM; Steward, CA; Todd, JA; Wicker, LS
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
We have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 mice accounts for the protection from type 1 diabetes (T1D) provided by the insulin-dependent diabetes susceptibility region 10 (Idd10), aout mouse. Susceptibility to T1D was correlated with genotype-dependent CD101 expression on multiple cell subsets, including Foxp3(+) regulatory CD4(+) T cells, CD11c(+) dendritic cells, and Gr1(+) myeloid cells. The correlation of CD101 expression on immune cells from four independent Idd10 haplotypes with the development of T1D supports the identity of Cd101 as Idd10. Because CD101 has been associated with regulatory T and Ag presentation cell functions, our results provide a further link between immune regulation and susceptibility to T1D.