Please browse here to find research papers published by our clients utilising Ozgene mice.


1. Regulation of the probability of mouse odorant receptor gene choice. (KO non-conditional)
M Khan; E Vaes; P Mombaerts
Cell, 2011 Nov 11;147(4):907-21
Max Planck Institute of Biophysics, 60438 Frankfurt, Germany.
2. Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures. (KO conditional)
E Loyens; A Schallier; SY Chai; D De Bundel; P Vanderheyden; Y Michotte; I Smolders
Seizure : the journal of the British Epilepsy Association, Oct;20(8):602-5. Epub 2011 May 25.
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
3. Analgesic Tolerance to High-Efficacy Agonists But Not to Morphine Is Diminished in Phosphorylation-Deficient S375A -Opioid Receptor Knock-In Mice. (KO/KI)
Grecksch G; Just S; Pierstorff C; Imhof AK; Glück L; Doll C; Lupp A; Becker A; Koch T; Stumm R; Höllt V; Schulz S
J Neurosci, 2011 Sep 28;31(39):13890-6
Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto-von-Guericke-University, D-39120 Magdeburg, Germany.
4. Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation (KO conditional)
Shimba S; Ogawa T; Hitosugi S; Ichihashi Y; Nakadaira Y; Kobayashi M; Tezuka M; Kosuge Y; Ishige K; Ito Y; Komiyama K; Okamatsu-Ogura Y; Kimura K; Saito M
PLoS One, 2011;6(9):e25231. Epub 2011 Sep 22.
Department of Health Science, School of Pharmacy, Nihon University, Funabashi, Chiba, Japan.
5. Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies (KO conditional)
Duysen, EG; Koentgen, F; Williams, GR; Timperley, CM; Schopfer, LM; Cerasoli, DM; Lockridge, O
Chem Res Toxicol, 2011 Sep 7. [Epub ahead of print]
Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-5950, USA.
6. AMP-activated protein kinase (AMPK) 12 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. (KO conditional)
O'Neill HM; Maarbjerg SJ; Crane JD; Jeppesen J; Jørgensen SB; Schertzer JD; Shyroka O; Kiens B; van Denderen BJ; Tarnopolsky MA; Kemp BE; Richter EA; Steinberg GR
Proc Natl Acad Sci U S A, 2011 Sep 6. [Epub ahead of print]
Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5.
7. Preclinical development of CAT-354, an IL-13-neutralising antibody, for the treatment of severe uncontrolled asthma. (KI non-conditional)
May, R; Monk, P; Cohen, E; Manuel, D; Dempsey, F; Davis, N; Dodd, A; Corkill, D; Woods, J; Joberty-Candotti, C; Conroy, L; Koentgen, F; Martin, E; Wilson, R; Brennan, N; Powell, J; Anderson, I.
Br J Pharmacol, 2011 Sep 6. doi: 10.1111/j.1476-5381.2011.01659.x. [Epub ahead of print]
MedImmune, Abington, Cambridge, UK.
8. Lung-specific loss of the laminin 3 subunit confers resistance to mechanical injury (KO conditional)
Urich, D; Eisenberg, JL; Hamill, KJ; Takawira, D; Chiarella, SE; Soberanes, S; Gonzalez, A; Koentgen, F; Manghi, T; Hopkinson, SB; Misharin, AV; Perlman, H; Mutlu, GM; Budinger, GR; Jones, JC
J Cell Sci, 2011 Sep 1;124(Pt 17):2927-37.
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
9. PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression (KO conditional)
Chi, Bun Chan; Chi, Wai Lee; Lin, Mei and Keqiang Ye; Xia, Liu; Xiaoling, Tang; Yongjun, Chen
EMBO J, 2011 Aug 16. doi: 10.1038/emboj.2011.281. [Epub ahead of print]
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
10. Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development. (KO/KI)
Ng, L; Lu, A; Swaroop, A; Sharlin, DS; Forrest, D.
J Neurosci, 2011 Aug 3;31(31):11118
NIDDK, Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892-1772, USA.
11. Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. (KO conditional)
Claudio, E; Cunningham, K; Li, W; Mukouyama, YS; O'Donnell, E; Siebenlist, U.; Soneji, K; Uchida, Y; Wang, H
Hum Mol Genet, 2011 Aug 15;20(16):3198-206. Epub 2011 May
Immune Activation Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
12. Human Cancer-Associated Mutations in A Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A Knock-in and Knockout Mice. (KO conditional)
Ruediger, R; Ruiz, J; Walter, G.
Mol Cell Biol, 2011 Sep;31(18):3832-44. Epub 2011 Jul
Department of Pathology, University of California at San Diego, La Jolla, CA 92093-0612, USA.
13. Evidence That Cd101 Is an Autoimmune Diabetes Gene in Nonobese Diabetic Mice. (KO conditional)
Bluestone, JA; Burren, O; Christensen, M; Clark, J; Finger, EB; Fraser, HI; Fusakio, ME; Houchins, JP; Howlett, SK; Koentgen, F; Masteller, EL; Mattner, J; Mohammed, JP; Moody, V; Moule, C; Naf, D; Peterson, LB; Rainbow, DB; Ridgway, WM; Steward, CA; Todd, JA; Wicker, LS
J Immunol, 2011 Jul 1;187(1):325-36. Epub 2011 May
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
14. Central nervous system dysfunction in a mouse model of FA2H deficiency. (KO conditional)
Bielawski, J; Cheng, H; Fullbright, G; Hama, H.; Han, X; Kern, MJ; Khan, PA; Li, JJ; Potter, KA; Rohrer, B; Scherer, SS; Venkata, JK; Yum, SW
GILA, 2011 Jul;59(7):1009-21. doi: 10.1002/glia.21172. Epub 2011 Apr
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
15. Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. (KO conditional)
An, J; Bun, Chan C; Hao, C; Liu, X; Luo, HR; Pradoldej, S; Ye, K.; Yepes, M
J Neurosci, 2011 Jun 1;31(22):8083
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
16. Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation. (KO/KI)
Gupta, M; He, JC; Li, Q; Lira, SA; Liu, J; Mayer, L; Morse, HC 3rd; Ning, H; Ouyang, X; Ozato, K; Qi, CF; Qin, L; Shin, MS; Xiong, H.; Yang, J; Zhang, R; Zhu, C
Nat Commun, 2011;2:314. doi: 10.1038/ncomms1311.
Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, New York 10029, USA.
17. Exploring phospholipase C-coupled Ca(2+) signalling networks using boolean modelling. (KO conditional)
Albert, R; Bhardwaj, G; Patterson, RL.; van, Rossum DB; Wells, CP
IET Syst Biol, 2011 May;5(3):174
The Pennsylvania State University, Department of Biology, University Park, PA 16801, USA.
18. Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. (KO non-conditional)
Boase, NA; Candi, E; Cook, DI; Dinudom, A; Koentgen, F; Kumar, S.; Melino, G; Rychkov, GY; Semsarian, C; Townley, SL; Tsoutsman, T; Voss, AK
Nat Commun, 2011;2:
Department of Haematology, Centre for Cancer Biology, SA Pathology, PO Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia.
19. Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: A study on the enzyme knockout mice. (KO conditional)
Cheng, Y; Duan, RD; Hansen, GH; Koentgen, F; Niels-Christiansen, LL; Nilsson, A; Ohlsson, L; Zhang, Y
J Lipid Research, 2011 Apr;52(4):771-81. Epub 2010 Dec
Gastroenterology and Nutrition Laboratory, Biomedical Center B11, Lund University, S-221 84 Lund, Sweden.
20. Adenosine Negative Feedback On A2A Adenosine Receptors Mediates Hypo-Responsiveness In Chronically Septic Mice (KO conditional)
Belikoff, B; Hatfield, S; Remick, DG.; Sitkovsky, M
Shock, 2011 Apr;35(4):38
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.
21. piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid Signaling (KO conditional)
Andrew, J. Morris; Hongmei, Ren; Huiyan, Huang; Krishna, Sarma; Michael, A. Frohman; Qun, Gao; Seok-Yong, Choi; Xiaoxue, Peng
Dev Cell, 2011 Mar 15;20(3):376
Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794-5140, USA.
22. The phosphoinositide kinase PIKfyve is vital in early embryonic development: Preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice (KI non-conditional)
Delvecchio, K; Ikonomov, OC; Jin, JP; Rappolee, D; Sbrissa, D; Shisheva, A.; Xie, Y
J Biol Chem, 2011 Apr 15;286(15):13404-13. Epub 2011 Feb
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
23. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response (Double targeting)
Anderton, H; Basten, A; Brink, R.; Gardam, S; Koentgen, F; Limaye, S; Silke, J; Turner, VM; Vaux, DL
Blood, 2011 Apr 14;117(15):4041-51. Epub 2011 Fe
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
24. Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase. (KO conditional)
Barrow, R; Cha, SH; Chakraborty, A; Juluri, KR; Kim, S; Kim, SF; Koldobskiy, MA3; Maag, D; Maxwell, MJ; Resnick, AC; Snowman, AM; Snyder, SH.
Cell Metab, 2011 Feb 2;13(2):215
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
25. IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools. (KO conditional)
Feng, J; Masiuk, M; Morse, HC 3rd.; Qi, CF; Shin, DM; Wang, H
J Immunol, 2011 Feb 1;186(3):1458-66. Epub 2010 Dec
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
26. Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB (KO conditional)
Boucher, KL; Choudhari, N; Hanno, AG; Hardesty, DA; Ma, JF; Maag, D; Maxwell, MJ; Pietropaoli, JW; Resnick, AC.; Saiardi, A; Snowman, AS; Snyder, SH.; Storm, PB; Xu, R
PNAS , 2011 Jan 25;108(4):1391-6. Epub 2011 Jan
The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
27. Vstm3 is a Member of the CD28 Family and an Important Modulator of T Cell Function (KO non-conditional)
Ardourel, D; Bilsborough, J; Blazar, BR; Bontadelli, K; Brandt, CS; Bucher, C; Bukowski, TR; Chadwick, EM; Fox, B; Gao, Z; Hammond, A; Hebb, L; Howard, ED; Johnston, J; Kuijper, JL; Levin, SD; Lewis, KE; Ostrander, CD; Ramsdell, F; Rixon, MW; Taft, DW; West, JW; Wolf, A; Xu, W
Euro J of Immunol, 2011 Apr;41(4):902-15. doi: 10.1002/eji.201041136. Epub 2011 Mar
Department of Immunology, ZymoGenetics, Inc., Seattle, WA, USA.
28. A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice. (KO conditional)
Belikoff, BG; Buras, JA; Georgiev, P; Hatfield, S; Lukashev, D; Ohta, A; Remick, DG; Sitkovsky, M.
J Immunol, 2011 Feb 15;186(4):2444-53. Epub 2011 Jan
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
29. Group V secretory phospholipase A2 plays a pathogenic role in myocardial ischaemia-reperfusion injury. (KO conditional)
Fujioka, D; Kawabata, K; Kobayashi, T; Kugiyama, K.; Mishina, H; Nakamura, T; Obata, JE; Saito, Y; Tamaru, S; Watanabe, K; Watanabe, Y; Yano, T
Cardiovasc Res, 2011 May 1;90(2):335-43. Epub 2010 Dec
Department of Internal Medicine II, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Yamanashi, Chuo 409-3898, Japan.
30. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. (KO/KI)
Brynedal, B; Hafler, JP; Joller, N; Kassam, N; Kuchroo, VK.; Levin, SD; Sharpe, AH; Spoerl, S
J Immunol, 2011 Feb 1;186(3):1338-42. Epub 2011 Ja
Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

30 Publication(s)