Please browse here to find research papers published by our clients utilising Ozgene mice.


1. Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet. (KO conditional)
BK Cole; MA Morris; WJ Grzesik; KA Leone; JL Nadler
Mediators Inflamm., 2012;2012:851798. doi: 10.1155/2012/851798. Epub 2012 Dec 27.
Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
2. NLRX1 does not inhibit MAVS-dependent antiviral signalling. (KO conditional)
F Soares; I Tattoli; ME Wortzman; D Arnoult; DJ Philpott; SE Girardin
Innate immunity, 2012 Dec 4. [Epub ahead of print]
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
3. Human myo-inositol monophosphatase 2, rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. (KO conditional)
T Ohnishi; Y Tanizawa; A Watanabe; T Nakamura; H Ohba; H Hirata; C Kaneda; Y Iwayama; T Arimoto; K Watanabe; I Mori; T Yoshikawa
Journal of neurochemistry, 2012 Dec 4. doi: 10.1111/jnc.12112. [Epub ahead of print]
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan.
4. Generation of mice with a conditional null Fraser syndrome 1 (Fras1) allele. (KO conditional)
JE Pitera; M Turmaine; AS Woolf; PJ Scambler
Genesis, 2012 Dec;50(12):892-8. doi: 10.1002/dvg.22045.
Molecular Medicine Unit, Institute of Child Health, University College London, United Kingdom.
5. Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase. (KO conditional)
E Loyens; D De Bundel; H Demaegdt; SY Chai; P Vanderheyden; Y Michotte; P Gard; I Smolders
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2012 Nov 26:1-11. [Epub ahead of print]
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
6. Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity. (KI non-conditional)
M Espéli; MR Clatworthy; S Bökers; KE Lawlor; AJ Cutler; F Köntgen; PA Lyons; KG Smith
The Journal of experimental medicine, 2012 Nov 19;209(12):2307-19. doi: 10.1084/jem.20121752.
Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, England, UK.
7. Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. (KO conditional)
SK Drexler; L Bonsignore; M Masin; A Tardivel; R Jackstadt; H Hermeking; P Schneider; O Gross; J Tschopp; AS Yazdi
Proceedings of the National Academy of Sciences of the United States of America, 2012 Nov 6;109(45):18384-9. doi: 10.1073/pnas.1209171109.
Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.
8. Elimination of Germinal Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen. (KI ROSA26)
TD Chan; K Wood; JR Hermes; D Butt; CJ Jolly; A Basten; R Brink
Immunity, 2012 Nov 6. pii: S1074-7613(12)00462-1. doi: 10.1016/j.immuni.2012.07.017.
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.
9. A phenotype survey of thirty-six mutant mouse strains with gene targeted defects in glycosyltransferases or glycan-binding proteins. (KO conditional)
SL Orr; D Le; JM Long; P Sobieszczuk; B Ma; H Tian; X Fang; JC Paulson; JD Marth; N Varki
Glycobiology, 2012 Oct 31. [Epub ahead of print]
Department of Pathology, University of California, San Diego, La Jolla, CA 92093-0687, USA.
10. Genetic Deletion of RALA and RALB Small GTPases Reveals Redundant Functions in Development and Tumorigenesis. (Bruce4 ES cells)
P Peschard; A McCarthy; V Leblanc-Dominguez; M Yeo; S Guichard; G Stamp; CJ Marshall
Current biology : CB, 2012 Oct 9. pii: S0960-9822(12)01076-7.
Oncogene Team, Division of Cancer Biology, Institute of Cancer Research, London SW3 6JB, UK.
11. A2B Adenosine Receptor Expression by Myeloid Cells Is Proinflammatory in Murine Allergic-Airway Inflammation. (KO conditional)
BG Belikoff; LJ Vaickus; M Sitkovsky; DG Remick
Journal of immunology (Baltimore, Md. : 1950), 2012 Oct 1;189(7):3707-13.
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
12. Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion. (KO conditional)
S Ye; ZA Karim; R Al Hawas; JE Pessin; AH Filipovich; SW Whiteheart
Blood, 2012 Sep 20;120(12):2484-92. Epub 2012 Jul 5
Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA.
13. Intestinal epithelial toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. (KO conditional)
CP Sodhi; MD Neal; R Siggers; S Sho; C Ma; MF Branca; T Prindle; AM Russo; A Afrazi; M Good; R Brower-Sinning; B Firek; MJ Morowitz; JA Ozolek; GK Gittes; TR Billiar; DJ Hackam
Gastroenterology, 2012 Sep;143(3):708-718.e5. Epub 2012 Jul 13.
Division of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA.
14. The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. (KO conditional)
S Jurado; K Gleeson; K O'Donnell; DJ Izon; CR Walkley; A Strasser; DM Tarlinton; J Heierhorst
The Journal of experimental medicine, Aug 27;209(9):1629-39. Epub 2012 Aug 13.
St. Vincent's Institute of Medical Research, The University of Melbourne, Melbourne, Victoria 3052, Australia.
15. Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype. (KO non-conditional)
EE Norgett; ZJ Golder; B Lorente-Cánovas; N Ingham; KP Steel; FE Karet Frankl
Proceedings of the National Academy of Sciences of the United States of America, 2012 Aug 21;109(34):13775-80. Epub 2012 Aug 7
Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom.
16. Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling. (KO conditional)
RB Perry; E Doron-Mandel; E Iavnilovitch; I Rishal; SY Dagan; M Tsoory; G Coppola; MK McDonald; C Gomes; DH Geschwind; JL Twiss; A Yaron; M Fainzilber
Neuron, 2012 Jul 26;75(2):294-305
Weizmann Institute of Science, Rehovot 76100, Israel.
17. Redd1 Is a Novel Marker of Testis Development but Is Not Required for Normal Male Reproduction. (KO conditional)
AJ Notini; PJ McClive; SJ Meachem; JA van den Bergen; PS Western; SE Gustin; VR Harley; P Koopman; AH Sinclair
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation, 2012 Jul 11. [Epub ahead of print]
Murdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Vic., Australia.
18. Role of STAT1 in the breast. (KO non-conditional)
SG Bailey; MS Cragg; PA Townsend
JAKSTAT., 2012 Jul 1;1(3):197-9. doi: 10.4161/jkst.20967.
Cancer Sciences Unit; Cancer Research UK Centre; Faculty of Medicine; University of Southampton; Southampton General Hospital; Southampton, UK.
19. Mice Deficient in GEM GTPase Show Abnormal Glucose Homeostasis Due to Defects in Beta-Cell Calcium Handling. (KO conditional)
JE Gunton; M Sisavanh; RA Stokes; J Satin; LS Satin; M Zhang; SM Liu; W Cai; K Cheng; GJ Cooney; DR Laybutt; T So; JC Molero; ST Grey; DA Andres; MS Rolph; CR Mackay
PloS one, 2012;7(6):e39462. Epub 2012 Jun 28
Diabetes and Transcription Factors Group, Garvan Institute of Medical Research, Sydney, Australia.
20. Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria. (KO conditional)
IS Kil; SK Lee; KW Ryu; HA Woo; MC Hu; SH Bae; SG Rhee
Molecular cell, 2012 Jun 8;46(5):584-94.
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.
21. Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors. (KI conditional)
A Tikoo; V Roh; KG Montgomery; I Ivetac; P Waring; R Pelzer; L Hare; M Shackleton; P Humbert; WA Phillips
PloS one, 2012;7(5):e36924. doi: 10.1371/journal.pone.0036924. Epub 2012 May 30.
Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
22. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. (KO conditional)
KM Hinkle; M Yue; B Behrouz; JC Dachsel; SJ Lincoln; EE Bowles; JE Beevers; BN Dugger; CB Kent; B Winner; I Prots; K Nishioka; W Lin; DW Dickson; CG Janus; MJ Farrer; HL Melrose
Molecular neurodegeneration, 2012 May 30;7(1):25. [Epub ahead of print]
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA.
23. Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice. (KO conditional)
F Wiede; SH Chew; C van Vliet; IJ Poulton; K Kyparissoudis; T Sasmono; K Loh; ML Tremblay; DI Godfrey; NA Sims; T Tiganis
PloS one, 2012;7(5):e36703. Epub 2012 May 8
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
24. Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. (KO conditional)
Y Liu; FS Korte; F Moussavi-Harami; M Yu; M Razumova; M Regnier; MT Chin
American journal of physiology. Heart and circulatory physiology, 2012 May;302(9):H1860-70. Epub 2012 Mar 9.
Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington 98109, USA.
25. Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response. (KO conditional)
CM Fang; S Roy; E Nielsen; M Paul; R Maul; A Paun; F Koentgen; FM Raval; E Szomolanyi-Tsuda; PM Pitha
Genes and immunity, 2012 Apr 26. doi: 10.1038/gene.2012.10. [Epub ahead of print]
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
26. Methionine sulfoxide reductase contributes to meeting dietary methionine requirements. (KO conditional)
H Zhao; G Kim; RL Levine
Archives of biochemistry and biophysics, 2012 Apr 13;522(1):37-43. [Epub ahead of print]
Laboratory of Biochemistry, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
27. PORCN Moonlights in a Wnt-Independent Pathway That Regulates Cancer Cell Proliferation. (KO conditional)
TM Covey; S Kaur; T Tan Ong; KD Proffitt; Y Wu; P Tan; DM Virshup
PloS one, 2012;7(4):e34532. Epub 2012 Apr 11.
Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
28. Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice. (KO conditional)
V Pham; AL Albiston; CE Downes; CH Wong; S Diwakarla; L Ng; S Lee; PJ Crack; SY Chai
Journal of neurotrauma, 2012 Apr 10;29(6):1243-8. Epub 2011 Dec 5
Howard Florey Institute, Victoria, Australia.
29. Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo. (KO conditional)
L Bai; MG Constantinides; SY Thomas; R Reboulet; F Meng; F Koentgen; L Teyton; PB Savage; A Bendelac
Journal of immunology (Baltimore, Md. : 1950), 2012 Apr 1;188(7):3053-61. Epub 2012 Mar 5.
Committee on Immunology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.
30. NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells. (KO non-conditional)
F Staehli; K Ludigs; LX Heinz; Q Seguín-Estévez; I Ferrero; M Braun; K Schroder; M Rebsamen; A Tardivel; C Mattmann; HR Macdonald; P Romero; W Reith; G Guarda; J Tschopp
Journal of immunology (Baltimore, Md. : 1950), 2012 Apr 15;188(8):3820-8. Epub 2012 Mar 12.
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
31. IAPs limit activation of RIP kinases by TNF receptor 1 during development. (Double targeting)
M Moulin; H Anderton; AK Voss; T Thomas; WW Wong; A Bankovacki; R Feltham; D Chau; WD Cook; J Silke; DL Vaux
The EMBO journal, 2012 Feb 10. doi: 10.1038/emboj.2012.18. [Epub ahead of print]
La Trobe Institute for Molecular Science, La Trobe University, Victoria, Australia.
32. Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice. (KO conditional)
I Caminschi; D Vremec; F Ahmet; MH Lahoud; JA Villadangos; KM Murphy; WR Heath; K Shortman
Molecular immunology, 2012 Feb;50(1-2):9-17. Epub 2011 Dec 29
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
33. Alcohol and aldehyde dehydrogenases: Retinoid metabolic effects in mouse knockout models. (KO non-conditional)
S Kumar; LL Sandell; PA Trainor; F Koentgen; G Duester
Biochimica et biophysica acta, 2012 Jan;1821(1):198-205. Epub 2011 Apr 15.
Sanford-Burnham Medical Research Institute, Development and Aging Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
34. Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype. (KO conditional)
X Tang; L Tian; G Esteso; SC Choi; AD Barrow; M Colonna; F Borrego; JE Coligan
Journal of immunology (Baltimore, Md. : 1950), 2012 Jan 15;188(2):548-58. Epub 2011 Dec 7
Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
35. Microenvironmental regulation by fibrillin-1. (KO conditional)
G Sengle; K Tsutsui; DR Keene; SF Tufa; EJ Carlson; NL Charbonneau; RN Ono; T Sasaki; MK Wirtz; JR Samples; LI Fessler; JH Fessler; K Sekiguchi; SJ Hayflick; LY Sakai
PLoS genetics, 2012 Jan;8(1):e1002425. doi: 10.1371/journal.pgen.1002425. Epub 2012 Jan 5
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America.
36. An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice. (KI conditional)
KM Kinross; KG Montgomery; M Kleinschmidt; P Waring; I Ivetac; A Tikoo; M Saad; L Hare; V Roh; T Mantamadiotis; KE Sheppard; GL Ryland; IG Campbell; KL Gorringe; JG Christensen; C Cullinane; RJ Hicks; RB Pearson; RW Johnstone; GA McArthur; WA Phillips
The Journal of clinical investigation, 2012 Feb 1;122(2):553-7. doi: 10.1172/JCI59309. Epub 2012 Jan 3.
Cancer Research Division, Peter MacCallum Cancer Centre (Peter Mac), East Melbourne, Victoria, Australia.

36 Publication(s)