Please browse here to find research papers published by our clients utilising Ozgene mice.


1. Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular HMGB1 in cellular protection. (KO conditional)
Huang H; Nace GW; McDonald KA; Tai S; Klune JR; Rosborough BR; Ding Q; Loughran P; Zhu X; Beer-Stolz; Chang EB; Billiar T; Tsung A
Hepatology (Baltimore, Md.), 2013 Dec 21. doi: 10.1002/hep.26976. [Epub ahead of print]
Department Of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
2. The role of Dectin-2 for host defense against systemic infection with Candida glabrata. (KO conditional)
Ifrim DC; Bain JM; Reid DM; Oosting M; Verschueren I; Gow NA; van Krieken JH; Brown GD; Kullberg BJ; Joosten LA; van der Meer JW; Koentgen F; Erwig LP; Quintin J; Netea MG
Infection and immunity, Infect Immun. 2013 Dec 16. [Epub ahead of print]
Department of Internal Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands.
3. Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks. (KO/KI)
M Chopin; C Seillet; S Chevrier; L Wu; HC 3rd Morse; GT Belz; ST Nutt
J Exp Med, 2013 Dec 16;210(13):2967-80. doi: 10.1084/jem.20130930.
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
4. Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation. (KI ROSA26)
E Rodríguez-Gallego; M Riera-Borrull; A Hernández-Aguilera; R Mariné-Casadó; A Rull; R Beltrán-Debón; F Luciano-Mateo; JA Menendez; A Vazquez-Martin; JJ Sirvent; V Martín-Paredero; AL Corbí; E Sierra-Filardi; G Aragonès; A García-Heredia; J Camps; C Alonso-Villaverde; J Joven
Mediators of inflammation, 2013;2013:953841. doi: 10.1155/2013/953841. Epub 2013 Dec 15.
Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Spain ; Campus of International Excellence Southern Catalonia, Spain. Catalan I
5. Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. (KI conditional)
V Marsh Durban; MM Deuker; MW Bosenberg; W Phillips; M McMahon
The Journal of clinical investigation, 2013 Dec 2;123(12):5104-18. doi: 10.1172/JCI69619. Epub 2013 Nov 8.
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA
6. Normal Autophagic Activity in Macrophages from Mice Lacking Gαi3, AGS3, or RGS19. (KI non-conditional)
A Vural; TJ McQuiston; JB Blumer; C Park; IY Hwang; Y Williams-Bey; CS Shi; DZ Ma; JH Kehrl
PloS one, 2013 Nov 28;8(11):e81886. doi: 10.1371/journal.pone.0081886.
B-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
7. Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice. (KI non-conditional)
EA Jacobsen; WE Lesuer; L Willetts; KR Zellner; K Mazzolini; N Antonios; B Beck; C Protheroe; SI Ochkur; D Colbert; P Lacy; R Moqbel; J Appleton; NA Lee; JJ Lee
Allergy, 2013 Nov 25. doi: 10.1111/all.12321. [Epub ahead of print]
Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ, USA, USA.
8. Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases. (KO conditional)
GL Vilas; SK Loganathan; J Liu; AK Riau; JD Young; JS Mehta; EN Vithana; JR Casey
Human molecular genetics, 2013 Nov 15;22(22):4579-90. doi: 10.1093/hmg/ddt307.
Membrane Protein Disease Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
9. Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality. (KO/KI)
MG Gall; Y Chen; AJ Vieira de Ribeiro; H Zhang; CG Bailey; DS Spielman; DM Yu; MD Gorrell
PloS one, 2013 Nov 6;8(11):e78378. doi: 10.1371/journal.pone.0078378.
Centenary Institute, Camperdown and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
10. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. (KI non-conditional)
MD Fullerton; S Galic; K Marcinko; S Sikkema; T Pulinilkunnil; ZP Chen; HM O'Neill; RJ Ford; R Palanivel; M O'Brien; DG Hardie; SL Macaulay; JD Schertzer; JR Dyck; BJ van Denderen; BE Kemp; GR Steinberg
Nature medicine, 2013 Nov 3. doi: 10.1038/nm.3372. [Epub ahead of print]
Department of Medicine, Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
11. Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression. (KI conditional)
CL Trejo; S Green; V Marsh; EA Collisson; G Iezza; WA Phillips; M McMahon
Cancer research, 2013 Nov 1;73(21):6448-61. doi: 10.1158/0008-5472.CAN-13-0681. Epub 2013 Sep 9.
Helen Diller Family Comprehensive Cancer Center. Departments of Cell and Molecular Pharmacology. Hematology and Oncology, and Pathology. University of California, San Francisco. San Francisco, California. Surgical Oncology Research Laboratory. Sir Peter M
12. Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction. (KO conditional)
R Xu; BD Paul; DR Smith; R Tyagi; F Rao; AB Khan; DJ Blech; MS Vandiver; MM Harraz; P Guha; I Ahmed; N Sen; M Gallagher; SH Snyder
Proceedings of the National Academy of Sciences of the United States of America, 2013 Oct 1;110(40):16181-16186. Epub 2013 Sep 16.
The Solomon H. Snyder Department of Neuroscience, Department of Pharmacology and Molecular Sciences, and Medical Scientist Training Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
13. Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy. (KO conditional)
SB Han; HP Ang; R Poh; SS Chaurasia; G Peh; J Liu; DT Tan; EN Vithana; JS Mehta
Investigative ophthalmology & visual science, 2013 Sep 27;54(9):6179-89. doi: 10.1167/iovs.13-12089.
Singapore National Eye Centre, Singapore.
14. Kruppel-like factor 15 is critical for vascular inflammation. (KO conditional)
Y Lu; L Zhang; X Liao; P Sangwung; DA Prosdocimo; G Zhou; AR Votruba; L Brian; YJ Han; H Gao; Y Wang; K Shimizu; K Weinert-Stein; M Khrestian; DI Simon; NJ Freedman; MK Jain
The Journal of clinical investigation, 2013 Sep 3. pii: 68552. doi: 10.1172/JCI68552. [Epub ahead of print]
15. The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice. (KO conditional)
M Iguchi; M Osanai; Y Hayashi; F Koentgen; GH Lee
Oncogene, 2013 Aug 19. doi: 10.1038/onc.2013.331. [Epub ahead of print]
Department of Pathology, Kochi University School of Medicine, Kochi, Japan.
16. Loss of the Nuclear Receptor Corepressor SLIRP Compromises Male Fertility. (KO conditional)
SM Colley; L Wintle; R Searles; V Russell; RC Firman; S Smith; K Deboer; DJ Merriner; B Genevieve; JM Bentel; BG Stuckey; MR Phillips; LW Simmons; DM de Kretser; MK O'Bryan; PJ Leedman
PloS one, 2013 Aug 15;8(8):e70700. doi: 10.1371/journal.pone.0070700.
Laboratory for Cancer Medicine, The University of Western Australia Centre for Medical Research, Western Australian Institute for Medical Research, Perth, Australia.
17. Genetic Deletion of Cell Division Autoantigen 1 Retards Diabetes-Associated Renal Injury. (KO conditional)
Z Chai; A Dai; Y Tu; J Li; T Wu; Y Wang; LJ Hale; F Koentgen; MC Thomas; ME Cooper
Journal of the American Society of Nephrology : JASN, 2013 Aug 8. [Epub ahead of print]
Proliferation and Fibrosis Laboratory.
18. IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. (KO conditional)
KE Hamilton; FK Noubissi; PS Katti; CM Hahn; SR Davey; ET Lundsmith; AJ Klein-Szanto; AD Rhim; VS Spiegelman; AK Rustgi
Carcinogenesis, 2013 Jul 11. [Epub ahead of print]
Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
19. Loss of Usp9x Disrupts Cortical Architecture, Hippocampal Development and TGFβ-Mediated Axonogenesis. (KO conditional)
S Stegeman; LA Jolly; S Premarathne; J Gecz; LJ Richards; A Mackay-Sim; SA Wood
PloS one, 2013 Jul 5;8(7):e68287. doi: 10.1371/journal.pone.0068287. Print 2013.
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia.
20. Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. (KO conditional)
P Nagarajan; Z Ge; B Sirbu; C Doughty; PA Agudelo Garcia; M Schlederer; AT Annunziato; D Cortez; L Kenner; MR Parthun
PLoS genetics, 2013 Jun;9(6):e1003518. doi: 10.1371/journal.pgen.1003518. Epub 2013 Jun 6.
Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA.
21. Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells. (KO conditional)
C Xing; X Fu; X Sun; P Guo; M Li; JT Dong
PloS one, 2013 Jun 5;8(6):e65538. doi: 10.1371/journal.pone.0065538. Print 2013.
Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin, China.
22. Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. (KO conditional)
FH Beraldo; IN Soares; DF Goncalves; J Fan; AA Thomas; TG Santos; AH Mohammad; M Roffé; MD Calder; S Nikolova; GN Hajj; AL Guimaraes; AR Massensini; I Welch; DH Betts; R Gros; M Drangova; AJ Watson; R Bartha; VF Prado; VR Martins; MA Prado
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013 May 31. [Epub ahead of print]
Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.
23. Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils. (KI non-conditional)
AD Doyle; EA Jacobsen; SI Ochkur; L Willetts; K Shim; J Neely; J Kloeber; WE Lesuer; RS Pero; P Lacy; R Moqbel; NA Lee; JJ Lee
Journal of leukocyte biology, 2013 May 24. [Epub ahead of print]
Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
24. Glucose homeostasis in mice is transglutaminase 2 independent. (KI non-conditional)
SE Iismaa; M Aplin; S Holman; TW Yiu; K Jackson; JG Burchfield; CJ Mitchell; L O'Reilly; A Davenport; J Cantley; C Schmitz-Peiffer; TJ Biden; GJ Cooney; RM Graham
PloS one, 2013 May 22;8(5):e63346. doi: 10.1371/journal.pone.0063346.
Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.
25. Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation. (KO conditional)
A Pratama; RR Ramiscal; DG Silva; SK Das; V Athanasopoulos; J Fitch; NK Botelho; PP Chang; X Hu; JJ Hogan; P Maña; D Bernal; H Korner; D Yu; CC Goodnow; MC Cook; CG Vinuesa
Immunity, 2013 Apr 18;38(4):669-80. doi: 10.1016/j.immuni.2013.01.011.
John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.
26. Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering. (KI non-conditional)
J Vukovic; GG Borlikova; MJ Ruitenberg; GJ Robinson; RK Sullivan; TL Walker; PF Bartlett
The Journal of neuroscience : the official journal of the Society for Neuroscience,
The University of Queensland, Brisbane, Queensland 4072, Australia.
27. Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type-Specific Functions of TLR4 during Sepsis. (KO conditional)
M Deng; MJ Scott; P Loughran; G Gibson; C Sodhi; S Watkins; D Hackam; TR Billiar
Journal of immunology (Baltimore, Md. : 1950), 2013 Apr 5. [Epub ahead of print]
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
28. Rgs13 constrains early B cell responses and limits germinal center sizes. (KO/KI)
IY Hwang; KS Hwang; C Park; KA Harrison; JH Kehrl
PloS one, 2013;8(3):e60139. doi: 10.1371/journal.pone.0060139. Epub 2013 Mar 22.
B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
29. Cellular specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury. (KO conditional)
GW Nace; H Huang; JR Klune; RE Eid; BR Rosborough; S Korff; S Li; RA Shapiro; DB Stolz; CP Sodhi; DJ Hackam; DA Geller; TR Billiar; A Tsung
Hepatology (Baltimore, Md.), 2013 Mar 4. doi: 10.1002/hep.26346. [Epub ahead of print]
Department of Surgery, University of Pittsburgh, Pittsburgh, PA.
30. Nitroxyl (HNO) Suppresses Vascular Nox2 Oxidase Activity. (KO conditional)
AA Miller; KF Maxwell; S Chrissobolis; ML Bullen; B Biomed; JM Ku; T Michael De Silva; S Selemidis; EU Hooker; GR Drummond; CG Sobey; BK Kemp-Harper
Free radical biology & medicine, 2013 Feb 28. pii: S0891-5849(13)00089-0. doi: 10.1016/j.freeradbiomed.2013.02.025. [Epub ahead of print]
Vascular Biology and Immunopharmacology Group, Department of Pharmacology, Monash University, Melbourne, VIC 3800, Australia.
31. TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. (KO conditional)
VW Tsai; L Macia; H Johnen; T Kuffner; R Manadhar; SB Jørgensen; KK Lee-Ng; HP Zhang; L Wu; CP Marquis; L Jiang; Y Husaini; S Lin; H Herzog; DA Brown; A Sainsbury; SN Breit
PloS one, 2013;8(2):e55174. doi: 10.1371/journal.pone.0055174. Epub 2013 Feb 28.
St Vincent's Centre for Applied Medical Research, St Vincent's Hospital and University of New South Wales, Sydney, New South Wales, Australia.
32. Dexras1, a Small GTPase, Is Required for Glutamate-NMDA Neurotoxicity. (KO conditional)
Y Chen; RS Khan; A Cwanger; Y Song; C Steenstra; S Bang; JH Cheah; J Dunaief; KS Shindler; SH Snyder; SF Kim
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013 Feb 20;33(8):3582-7. doi: 10.1523/JNEUROSCI.1497-12.2013.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
33. Pregnancy Associated Plasma Protein A2 (PAPP-A2) Affects Bone Size and Shape and Contributes to Natural Variation in Postnatal Growth in Mice. (KO conditional)
JK Christians; DR de Zwaan; SH Fung
PloS one, 2013;8(2):e56260. doi: 10.1371/journal.pone.0056260. Epub 2013 Feb 15.
Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
34. Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2. (KO conditional)
W Shi; AL Bain; B Schwer; F Al-Ejeh; C Smith; L Wong; H Chai; MS Miranda; U Ho; M Kawaguchi; Y Miura; JW Finnie; M Wall; J Heierhorst; C Wicking; KJ Spring; FW Alt; KK Khanna
PLoS genetics, 2013 Feb;9(2):e1003298. doi: 10.1371/journal.pgen.1003298. Epub 2013 Feb 7.
Queensland Institute of Medical Research, Herston, Australia.
35. Divergent effects of endogenous and exogenous GILZ in models of inflammation and arthritis. (KO conditional)
D Ngo; E Beaulieu; R Gu; A Leaney; L Santos; H Fan; Y Yang; W Kao; J Xu; V Escriou; S Loiler; MJ Vervoordeldonk; EF Morand
Arthritis and rheumatism, 2013 Jan 17. doi: 10.1002/art.37858. [Epub ahead of print]
Monash University, Clayton, Victoria, Australia.
36. Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo. (KI ROSA26)
JR Sundaram; CP Poore; NH Sulaimee; T Pareek; AB Asad; R Rajkumar; WF Cheong; MR Wenk; GS Dawe; KH Chuang; HC Pant; S Kesavapany
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013 Jan 2;33(1):334-343.
Department of Biochemistry, Centre for Life Sciences, National University of Singapore, 28 Medical Drive, #04-21, Singapore 117456.

36 Publication(s)