Publication in detail

Euro J of Immunol 2011 Apr;41(4):902-15. doi: 10.1002/eji.201041136. Epub 2011 Mar

Vstm3 is a Member of the CD28 Family and an Important Modulator of T Cell Function

Ardourel, D; Bilsborough, J; Blazar, BR; Bontadelli, K; Brandt, CS; Bucher, C; Bukowski, TR; Chadwick, EM; Fox, B; Gao, Z; Hammond, A; Hebb, L; Howard, ED; Johnston, J; Kuijper, JL; Levin, SD; Lewis, KE; Ostrander, CD; Ramsdell, F; Rixon, MW; Taft, DW; West, JW; Wolf, A; Xu, W

Department of Immunology, ZymoGenetics, Inc., Seattle, WA, USA.

Members of the CD28 family play important roles in regulating T-cell functions and share a common gene structure profile. We have identified VSTM3 as a protein whose gene structure matches that of the other CD28 family members. This protein (also known as TIGIT and WUCAM) has been previously shown to affect immune responses and is expressed on NK cells, activated and memory T cells, and Tregs. The nectin-family proteins CD155 and CD112 serve as counter-structures for VSTM3, and CD155 and CD112 also bind to the activating receptor CD226 on T cells and NK cells. Hence, this group of interacting proteins forms a network of molecules similar to the well-characterized CD28-CTLA-4-CD80-CD86 network. In the same way that soluble CTLA-4 can be used to block T-cell responses, we show that soluble Vstm3 attenuates T-cell responses in vitro and in vivo. Moreover, animals deficient in Vstm3 are more sensitive to autoimmune challenges indicating that this new member of the CD28 family is an important regulator of T-cell responses.

ยป Online Version

Proven Track Record

The team at Ozgene has over two decades of experience creating customised knockout and knock-in mice for pivotal medical research globally. Over 400 scientific publications are based on research using Ozgene mice.

Go to Publications

Global Client Base

Ozgene generates genetically customised mice for researchers around the world. Ozgene mice can be found in 31 different countries on 5 continents from small academic institutions to multinational pharmaceutical companies.

See Client Papers

Lean Management

Ozgene is applying Lean Management principles to deliver the highest quality services and shortest lead times to our customers. The implementation of Lean Culture has already seen an improvement in our processes and timelines.

Read More