Publications

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2023

Diabetes. 2023 Sep 12:db230035. doi: 10.2337/db23-0035. Online ahead of print.

Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia

Harry B Cutler, Søren Madsen, Stewart W C Masson, Kristen C Cooke, Meg Potter, James G Burchfield, Jacqueline Stöckli, Marin E Nelson, Gregory J Cooney, David E James

Service type: Knock-in mice

2023

Nat Commun. 2023 Aug 19;14(1):5053. doi: 10.1038/s41467-023-40681-4.

CD98hc is a target for brain delivery of biotherapeutics

Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis.

Service type: Knock-in mice

2023

Immunity. 2023 Aug 8;56(8):1778-1793.e10. doi: 10.1016/j.immuni.2023.06.020. Epub 2023 Jul 17.

Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks

Milas Ugur, R Jacob Labios, Chloe Fenton, Konrad Knöpper, Katarzyna Jobin, Fabian Imdahl, Gosia Golda, Kathrin Hoh, Anika Grafen, Tsuneyasu Kaisho, Antoine-Emmanuel Saliba, Dominic Grün, Georg Gasteiger, Marc Bajénoff, Wolfgang Kastenmüller

Service type: Knock-in mice

2023

JCI Insight. 2023 Jul 10;8(13):e134685. doi: 10.1172/jci.insight.134685.

Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors

Mritunjay Pandey, Jian-Hua Zhang, Poorni R Adikaram, Claire Kittock, Nicole Lue, Adam Awe, Katherine Degner, Nirmal Jacob, Jenna Staples, Rachel Thomas, Allison B Kohnen, Sundar Ganesan, Juraj Kabat, Ching-Kang Chen, William F Simonds

Service type: Knock-in mice

2023

Nature. 2023 Jun;618(7967):1072-1077. doi: 10.1038/s41586-023-06191-5. Epub 2023 May 17.

Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

Nobuhiko Kayagaki, Irma B. Stowe, Kamela Alegre, Ishan Deshpande, Shuang Wu, Zhonghua Lin, Opher S. Kornfeld, Bettina L. Lee, Juan Zhang, John Liu, Eric Suto, Wyne P. Lee, Kellen Schneider, WeiYu Lin, Dhaya Seshasayee, Tushar Bhangale, Cecile Chalouni, Matthew C. Johnson, Prajakta Joshi, Jan Mossemann, Sarah Zhao, Danish Ali, Neil M. Goldenberg, Blayne A. Sayed, Benjamin E. Steinberg, Kim Newton, Joshua D. Webster, Ryan L. Kelly, Vishva M. Dixit

Service type: Knock-in mice

2023

Cells. 2023 Jun 1;12(11):1528. doi: 10.3390/cells12111528.

Corneal Edema in Inducible Slc4a11 Knockout Is Initiated by Mitochondrial Superoxide Induced Src Kinase Activation

Diego G. Ogando, Edward T. Kim, Shimin Li, Joseph A. Bonanno

Service type: Knockout mice

2023

Front Immunol. 2023 May 18:14:1119750. doi: 10.3389/fimmu.2023.1119750. eCollection 2023.

The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver

Sophia Y Y Mah, Hannah K Vanyai, Yuqing Yang, Anne K Voss, Tim Thomas

Service type: Knockout mice

2023

J Neuroinflammation. 2023 May 3;20(1):106. doi: 10.1186/s12974-023-02785-y.

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS

Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel

Service type: Humanized mice

2023

J Neuroinflammation. 2023 Apr 30;20(1):100. doi: 10.1186/s12974-023-02784-z.

Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis

Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem, Sarah K. Williams

Service type: Humanized mice

2023

Sci Adv. 2023 Mar 31;9(13):eadd6911. doi: 10.1126/sciadv.add6911. Epub 2023 Mar 31.

PI(4,5)P2-dependent regulation of endothelial tip cell specification contributes to angiogenesis

Elizabeth M Davies, Rajendra Gurung, Kai Qin Le, Katherine T T Roan, Richard P Harvey, Geraldine M Mitchell, Quenten Schwarz, Christina A Mitchell

Service type: Knockout mice