Publication in detail

Bioorg Med Chem Lett 1999 Oct 4;9(19):278

A direct method for the formation of peptide and carbohydrate dendrimers.

Koentgen, F; Lambert, JN.; Langley, J; Mitchell, JP; Roberts, KD

School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia.

Two new methods for the modification of PAMAM dendrimers have been developed which allow the covergent synthesis of either peptide or carbohydrate-bearing dendrimer molecules. Both methods involve condensation between hydroxylamino nucleophiles and appropriate carbonyl-bearing reaction partners.

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