|Coat colour||Albino (a/a Tyrp1b/Tyrp1b Tyrc/Tyrc)|
|JAX stock number||000646|
- MHC haplotype: H2Ka
- Complement factor: C5 deficient
- High social dominance of males in competition for females.
- High spontaneous incidence of lung adenomas and mammary tumours in breeding females.
- Congenital defects include cleft lip/palate and polydactyly at a prevalence of up to 10%.
- Incidence of nephritis and amyloidosis nearly 100% at 15 months.
- Low aggression and low responsiveness in general (activity, alcohol, anaesthesia, metabolism).
- Presence of hearing loss and blindness.
- A/J mice are challenging breeders, exhibiting reduced productivity and high incidence of non-productive matings. They may require some special maintenance. A/J mice tend to be very docile and easy to work with. A 2022 study found vaginal septa in <2% of females.
- A/J inbred mice were developed by LC Strong in 1921 from a cross between a Cold Spring Harbor albino and a Bagg albino stock.
- The strain was subsequently maintained and bred by Arthur Cloudman after receiving breeders in 1928.
- A/J inbred mice are a valuable model for a wide range of research areas, including cancer, immunology, cardiovascular, developmental biology, sensorineural, behaviour, and disease studies.
- They are also used in studies on CD antigens, antigen receptors, and histocompatibility markers.
- These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: JAX General Terms and Conditions
- JAX mice are the gold standard for animal model research
- Ozgene ARC terms and Conditions
- Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.