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2026

Mol Cancer. 2026 Jan 7;25(1):5. doi: 10.1186/s12943-025-02510-8.

BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans

Haran Sivakumaran, Sneha Nair, Mainá Bitar, Xue Lu, Lu Wang, Ji Liu, Deshapriya S Karunarathne, P Prakrithi, Sebastien Jacquelin, Isela Sarahi Rivera, Kristine M Hillman, Susanne Kaufmann, Rebekah Ziegman, Wei Shi, Sarah Alexandrou, C Elizabeth Caldon, Rakesh N Veedu, Quan H Nguyen, Jonathan Beesley, Michelle N Wykes, Juliet D French, Stacey L Edwards

Service type: Stock strains

2025

Biochim Biophys Acta Gen Subj. 2025 Nov 11;1870(1):130885. doi: 10.1016/j.bbagen.2025.130885. Online ahead of print.

Hepatic response to ethanol feeding in a hepatocyte-specific fatty acid binding protein-4 knock out mouse model

Neha Attal, Trenton A Pritt, Melissa Stair, Tony E Reeves, Iain H McKillop

Service type: Knockout mice

2025

Nat Immunol . 2025 Dec;26(12):2270-2279. doi: 10.1038/s41590-025-02333-1. Epub 2025 Nov 21.

Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors

Svetlana Altshuler-Keylin, Nicole Caduff, Isabel E Ishizuka, Rohit Reja, Katherine Nutsch, Chan Gao, Joy Wang, Ulrike Kaufmann, Mayra Cruz Tleugabulova, Elizabeth Dixon, Hannah Little-Hooy, Rachana Pradhan, Rosa Barreira da Silva, Teresita L Arenzana, Min Xu 5, Mark S Wilson, Jill Schartner, Soyoung A Oh, Kim Newton, Vishva M Dixit, Sascha Rutz

Service type: Knock-in mice

2025

Mol Ther Nucleic Acids . 2025 Nov 10;36(4):102770. doi: 10.1016/j.omtn.2025.102770. eCollection 2025 Dec 9.

Base editing strategies for in vivo correction of two highly recurrent phenylketonuria variants

Aidan Quigley, Ishaan Jindal, Thomas Campion, Delaney Rutherford, Yongseok Han, Walsh Quigley, Ping Qu, Kiran Musunuru, Rebecca Ahrens-Nicklas, Xinying Hong, Xiao Wang

Service type: Humanized mice

2025

Metabolism. 2025 Nov:172:156358. doi: 10.1016/j.metabol.2025.156358. Epub 2025 Aug 5.

A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity

Christine Mund, Anupam Sinha, Anika Aderhold, Ivona Mateska, Eman Hagag, Sofia Traikov, Bettina Gercken, Andres Soto, Jonathan Pollock, Lilli Arndt, Michele Wölk, Natalie Werner, Georgia Fodelianaki, Pallavi Subramanian, Kyoung-Jin Chung, Sylvia Grossklaus, Mathias Langner, Mohamed Elgendy, Tatyana Grinenko, Ben Wielockx, Andreas Dahl, Martin Gericke, Matthias Blüher, Ünal Coskun, David Voehringer, Maria Fedorova, Mirko Peitzsch, Peter J Murray, Triantafyllos Chavakis, Vasileia Ismini Alexaki

Service type: Knock-in mice

2025

Brain Behav Immun. 2025 Nov:130:106099. doi: 10.1016/j.bbi.2025.106099. Epub 2025 Sep 3.

Comparing two anti-inflammatory reflexes: Splanchnic and hypothalamic-pituitary-adrenal

Michael McKinley, Song T Yao, Davide Martelli, Robin McAllen

Service type: Stock strains

2025

Am J Physiol Cell Physiol. 2025 Nov 1;329(5):C1498-C1510. doi: 10.1152/ajpcell.00230.2025. Epub 2025 Oct 3.

Cachexia progression differs among mouse models of metastatic triple-negative breast cancer

Alastair A E Saunders, Chris Karagiannis, Wayne X Du, Lauren S James, Rachel E Thomson, Robin L Anderson, Paul Gregorevic

Service type: Stock strains

2025

Res Sq [Preprint]. 2025 Oct 24:rs.3.rs-7810883. doi: 10.21203/rs.3.rs-7810883/v1.

NUDT21 Regulates Macrophage Cytokine Responses via Alternative Polyadenylation in ARDS

Tingting Mills, Hui Liu, Yu Wang, Scott Collum, Kai-Lieh Huang, Maria Gacha-Garay, Sarah Shin, Xiaoyi Yuan, Megan Ballinger, Hari Yalamanchili, Eric Wagner, Harry Karmouty

Service type: Knock-in mice

2025

Sci Adv. 2025 Oct 17;11(42):eadz1726. doi: 10.1126/sciadv.adz1726. Epub 2025 Oct 17.

Lyn restrains lupus via kinase-independent mechanisms that limit Toll-like receptor activation and type I interferon responsiveness

Elan L'Estrange-Stranieri, Timothy A Gottschalk, Anne M Kong, Mhairi J Maxwell, Ee Shan Pang, Evelyn Tsantikos, David M Tarlinton, Meredith O'Keeffe, Mark D Wright, Margaret L Hibbs

Service type: Knock-in mice

2025

Mol Ther. 2025 Oct 11:S1525-0016(25)00842-1. doi: 10.1016/j.ymthe.2025.10.021. Online ahead of print.

Pancreatic transdifferentiation of NOD mouse livers prevented development of hyperglycemia

Alexandra L G Mahoney, Binhai Ren, Najah T Nassif, Bronwyn A O'Brien, Grant J Logan, Catherine A Gorrie, Ian E Alexander, Ann M Simpson

Service type: Stock strains

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