Publications

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2023

EMBO Rep. 2023 Nov 14:e57972. doi: 10.15252/embr.202357972. Online ahead of print.

MAPL loss dysregulates bile and liver metabolism in mice

Vanessa Goyon, Aurèle Besse-Patin, Rodolfo Zunino, Olesia Ignatenko, Mai Nguyen, Étienne Coyaud, Jonathan M Lee, Bich N Nguyen, Brian Raught, Heidi M McBride

Service type: Knock-in mice

2023

Am J Physiol Gastrointest Liver Physiol. 2023 Nov 14. doi: 10.1152/ajpgi.00140.2023. Online ahead of print.

Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation

Maria A. Ilomäki, Lauri Polari, Carl-Gustaf A. Stenvall, Mina Tayyab, Kirah Kähärä, Karen M. Ridge, Diana M. Toivola

Service type: Knockout mice

2023

Am J Hum Genet. 2023 Nov 3:S0002-9297(23)00358-0. doi: 10.1016/j.ajhg.2023.10.005. Online ahead of print.

Efficient in vivo prime editing corrects the most frequent phenylketonuria variant, associated with high unmet medical need

Dominique L Brooks, Madelynn N Whittaker, Ping Qu, Kiran Musunuru, Rebecca C Ahrens-Nicklas, Xiao Wang

Service type: Knock-in mice

2023

Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2306761120. doi: 10.1073/pnas.2306761120. Epub 2023 Sep 27.

Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation

Gianluca Scarno, Julija Mazej, Mattia Laffranchi, Chiara Di Censo, Irene Mattiola, Arianna M Candelotti, Giuseppe Pietropaolo, Helena Stabile, Cinzia Fionda, Giovanna Peruzzi, Stephen R Brooks, Wanxia Li Tsai, Yohei Mikami, Giovanni Bernardini, Angela Gismondi, Silvano Sozzani, James P Di Santo, Christian A J Vosshenrich, Andreas Diefenbach, Massimo Gadina, Angela Santoni, Giuseppe Sciumè

Service type: Knockout mice

2023

Diabetes. 2023 Sep 12:db230035. doi: 10.2337/db23-0035. Online ahead of print.

Dual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemia

Harry B Cutler, Søren Madsen, Stewart W C Masson, Kristen C Cooke, Meg Potter, James G Burchfield, Jacqueline Stöckli, Marin E Nelson, Gregory J Cooney, David E James

Service type: Knock-in mice

2023

Nat Commun. 2023 Aug 19;14(1):5053. doi: 10.1038/s41467-023-40681-4.

CD98hc is a target for brain delivery of biotherapeutics

Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis.

Service type: Knock-in mice

2023

Immunity. 2023 Aug 8;56(8):1778-1793.e10. doi: 10.1016/j.immuni.2023.06.020. Epub 2023 Jul 17.

Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks

Milas Ugur, R Jacob Labios, Chloe Fenton, Konrad Knöpper, Katarzyna Jobin, Fabian Imdahl, Gosia Golda, Kathrin Hoh, Anika Grafen, Tsuneyasu Kaisho, Antoine-Emmanuel Saliba, Dominic Grün, Georg Gasteiger, Marc Bajénoff, Wolfgang Kastenmüller

Service type: Knock-in mice

2023

JCI Insight. 2023 Jul 10;8(13):e134685. doi: 10.1172/jci.insight.134685.

Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors

Mritunjay Pandey, Jian-Hua Zhang, Poorni R Adikaram, Claire Kittock, Nicole Lue, Adam Awe, Katherine Degner, Nirmal Jacob, Jenna Staples, Rachel Thomas, Allison B Kohnen, Sundar Ganesan, Juraj Kabat, Ching-Kang Chen, William F Simonds

Service type: Knock-in mice

2023

Nature. 2023 Jun;618(7967):1072-1077. doi: 10.1038/s41586-023-06191-5. Epub 2023 May 17.

Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

Nobuhiko Kayagaki, Irma B. Stowe, Kamela Alegre, Ishan Deshpande, Shuang Wu, Zhonghua Lin, Opher S. Kornfeld, Bettina L. Lee, Juan Zhang, John Liu, Eric Suto, Wyne P. Lee, Kellen Schneider, WeiYu Lin, Dhaya Seshasayee, Tushar Bhangale, Cecile Chalouni, Matthew C. Johnson, Prajakta Joshi, Jan Mossemann, Sarah Zhao, Danish Ali, Neil M. Goldenberg, Blayne A. Sayed, Benjamin E. Steinberg, Kim Newton, Joshua D. Webster, Ryan L. Kelly, Vishva M. Dixit

Service type: Knock-in mice

2023

Cells. 2023 Jun 1;12(11):1528. doi: 10.3390/cells12111528.

Corneal Edema in Inducible Slc4a11 Knockout Is Initiated by Mitochondrial Superoxide Induced Src Kinase Activation

Diego G. Ogando, Edward T. Kim, Shimin Li, Joseph A. Bonanno

Service type: Knockout mice