C57BL/10ScSn strain is characterized by a high incidence of spontaneous deviants, making it a potential source for mutants with unique genetic characteristics.
This strain exhibits a remarkable degree of genetic distinctiveness, making it a valuable tool in genetic research.
It is commonly used as a reference strain for the development of resistant congenic lines that differ from the parental strain by single histocompatibility loci.
This strain is known to exhibit congenital abnormalities such as microphthalmia (small eyes), corneal opacities (cloudy corneas), and hydrocephalus (accumulation of cerebrospinal fluid in the brain).
Barbering, a behaviour where mice chew or pluck their own fur or that of cage mates, is also common in this strain.
The C57BL/10ScSn strain traces its origins back to the original work of C.C. Little in 1921, who created this strain through a mating of Miss Abbie Lathrop’s stock. The strain was then passed on to W.L. Russell, and subsequently to J.P. Scott (Sc) at F26 as a separate subline, and later to George Snell (Sn) at F35-36.
The C57BL/10ScSn strain has been widely used in various research fields and has numerous applications due to its unique genetic characteristics, making it a valuable tool in advancing scientific knowledge and understanding various biological processes, diseases, and therapies.
