B10ScSn

B10ScSn

B10ScSn

Strain details
Nomenclature C57BL/10ScSnOzarc
Common nameB10ScSn
SynonymsB10, B10 Scotty Snell
StrainInbred
Coat colourBlack (a/a)
SpeciesMouse
Genetic background-
LocationArea Oz2
Weekly wean target10 males, 10 females

Strain description

  • MHC haplotype: H2Kb
  • C57BL/10ScSn strain is characterized by a high incidence of spontaneous deviants, making it a potential source for mutants with unique genetic characteristics.
  • This strain exhibits a remarkable degree of genetic distinctiveness, making it a valuable tool in genetic research.
  • It is commonly used as a reference strain for the development of resistant congenic lines that differ from the parental strain by single histocompatibility loci.
  • This strain is known to exhibit congenital abnormalities such as microphthalmia (small eyes), corneal opacities (cloudy corneas), and hydrocephalus (accumulation of cerebrospinal fluid in the brain).
  • Barbering, a behaviour where mice chew or pluck their own fur or that of cage mates, is also common in this strain.
  • The C57BL/10ScSn strain traces its origins back to the original work of C.C. Little in 1921, who created this strain through a mating of Miss Abbie Lathrop’s stock. The strain was then passed on to W.L. Russell, and subsequently to J.P. Scott (Sc) at F26 as a separate subline, and later to George Snell (Sn) at F35-36.
  • The C57BL/10ScSn strain has been widely used in various research fields and has numerous applications due to its unique genetic characteristics, making it a valuable tool in advancing scientific knowledge and understanding various biological processes, diseases, and therapies.

Past ARC and transfer reports:

Current Ozgene ARC reports (from 01-Jun-2023)

  • Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.
  • Feher L, et al., Correlations between haematological parameters and age in inbred strain C57BL/10ScSn mice. Acta Biol Acad Sci Hung. 1974;25(3):173-80