BN/RijHsd
BN/RijHsd
| Strain details | |
|---|---|
| Nomenclature | BN/RijHsdOzarc |
| Common name | BN/RijHsd |
| Synonyms | Brown Norway Rat, BN |
| Strain | Inbred |
| Coat colour | Non-agouti brown (a, b, C, hi ) |
| Species | Rat |
| Genetic background | - |
| Location | Area Oz4 |
| Weekly wean target | <10 males, <10 females |
Strain descriptions
- Haplotype: RT1n.
- The BN strain is a docile rat.
- Low litter average: 4.5.
- Median lifespan is around 28-31 months.
- Histocompatibility: RT1n, RT2a or RT2b, RT3b, RT8b.
- Substrains vary with respect to Pep-3 and RT2.
- Low plasma ceruloplasmin levels.
- Hyper-responsive lungs.
- Hydronephrosis and hydroureter common.
- Dimethylbenzanthracene induced a transplantable myeloid leukemia.
- High incidence of urinary bladder and ureteral carcinomas in older males.
- Moderate incidence of pituitary adenomas in older animals
- Resistant to experimental allergic encephalomyelitis.
- Resistant to induction of autologous immune complex glomerulonephritis
- Low activity of NK cells compared with other rat strains.
- Higher percentage of paradoxical sleep than LEW.
- Susceptible to the development of mercury-induced autoimmunity to renal basement membranes.
- Immunologic model as the strain is unique in its expression of the high lgE – responder phenotype.
- Low preference for ethanol and low capability to develop acute tolerance to ethanol hypnosis.
- BN/RijHsd rats were derived from a nucleus colony obtained directly from the TNO Institute, the Netherlands.
- Received from Animal Resource Centre (ARC) in 2023.
- Behaviour, hydronephrosis, cancer research, myelocytic leukemia, aging, HgCl2-induced nephritis.
| BN/RijHsd | BN/RijHsdOzarc | |
|---|---|---|
| WKS | MALE | FEMALE |
| 3 | 32 - 55 | 31 - 58 |
| 4 | 48 - 80 | 39 - 69 |
| 5 | 64 - 108 | 61 - 90 |
| 6 | 87 - 142 | 80 - 111 |
| 7 | 115 - 176 | 90 - 125 |
| 8 | 129 - 210 | 106 - 141 |
| 9 | 173 - 230 | 122 - 152 |
| 10 | 138 - 248 | 122 - 164 |
| 11 | 134 - 270 | 127 - 176 |
| 12 | 216 - 277 | 134 - 182 |
| 13 | 229 - 292 | 144 - 187 |
| 14 | 234 - 305 | 177 - 187 |
Past ARC reports:
Current Ozgene ARC reports (from 01-Jun-2023)
- This strain is housed in Area Oz4
- Please see Oz4 health reports on our Biosecurity page
- Animals are not allowed to be used for propagation.
- Ozgene ARC terms and Conditions
- Rat images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.
- Nishisono S, Kusaba M, Adan Y Imaizumi K (1999) Induction of atherosclerosis in Brown Norway rats by immunization with ovalbumin. Biosci. Biothechnol. Biochem. 63, 379-383.
- Bottger A, Den Bieman M, Lankhorst Æ, Van Lith HA (1996) Strain specific response to hypercholesterolemic diets in the rat. Lab. Anim. 30, 149-157.
- Peers SH, Duncan GS, Flower RJ, Bolton C (1995) Endogeneous corticosteroids modulate lymphoproliferation and susceptibility to experimental allergic encephalo- myelitis in the Brown-Norway rat. International Archives of Allergy and Immunology 106, 20-24.
