BN/RijHsd

BN/RijHsd

BN/RijHsd

Strain details
Nomenclature BN/RijHsdOzarc
Common nameBN/RijHsd
SynonymsBrown Norway Rat, BN
StrainInbred
Coat colourNon-agouti brown (a, b, C, hi )
SpeciesRat
Genetic background-
LocationArea Oz4

Strain descriptions

  • Haplotype: RT1n.
  • The BN strain is a docile rat.
  • Low litter average: 4.5.
  • Median lifespan is around 28-31 months.
  • Histocompatibility: RT1n, RT2a or RT2b, RT3b, RT8b.
  • Substrains vary with respect to Pep-3 and RT2.
  • Low plasma ceruloplasmin levels.
  • Hyper-responsive lungs.
  • Hydronephrosis and hydroureter common.
  • Dimethylbenzanthracene induced a transplantable myeloid leukemia.
  • High incidence of urinary bladder and ureteral carcinomas in older males.
  • Moderate incidence of pituitary adenomas in older animals
  • Resistant to experimental allergic encephalomyelitis.
  • Resistant to induction of autologous immune complex glomerulonephritis
  • Low activity of NK cells compared with other rat strains.
  • Higher percentage of paradoxical sleep than LEW.
  • Susceptible to the development of mercury-induced autoimmunity to renal basement membranes.
  • Immunologic model as the strain is unique in its expression of the high lgE – responder phenotype.
  • Low preference for ethanol and low capability to develop acute tolerance to ethanol hypnosis.
  • BN/RijHsd rats were derived from a nucleus colony obtained directly from the TNO Institute, the Netherlands.
  • Received from Animal Resource Centre (ARC) in 2023.
  • Behaviour, hydronephrosis, cancer research, myelocytic leukemia, aging, HgCl2-induced nephritis.
BN/RijHsd
BN/RijHsdOzarc
WKSMALEFEMALE
332 - 5531 - 58
4
48 - 8039 - 69
564 - 10861 - 90
687 - 14280 - 111
7115 - 17690 - 125
8129 - 210106 - 141
9173 - 230122 - 152
10138 - 248122 - 164
11134 - 270127 - 176
12216 - 277134 - 182
13229 - 292144 - 187
14234 - 305177 - 187

Past ARC and transfer reports:

Current Ozgene ARC reports (from 01-Jun-2023)

  • Rat images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.
  • Nishisono S, Kusaba M, Adan Y Imaizumi K (1999) Induction of atherosclerosis in Brown Norway rats by immunization with ovalbumin. Biosci. Biothechnol. Biochem. 63, 379-383.
  • Bottger A, Den Bieman M, Lankhorst Æ, Van Lith HA (1996) Strain specific response to hypercholesterolemic diets in the rat. Lab. Anim. 30, 149-157.
  • Peers SH, Duncan GS, Flower RJ, Bolton C (1995) Endogeneous corticosteroids modulate lymphoproliferation and susceptibility to experimental allergic encephalo- myelitis in the Brown-Norway rat. International Archives of Allergy and Immunology 106, 20-24.