C57BL/6JOzarc

C57BL/6JOzarc

C57BL/6JOzarc

Strain details
NomenclatureC57BL/6JOzarc
Common nameB6
SynonymsB6J, B6/J, Black6
StrainInbred
Coat ColourBlack (a/a)
SpeciesMouse
JAX stock number000664
LocationArea Oz2, Oz3, Oz5
Weekly wean target250 males, 900 females

Strain description

  • MHC haplotype: H2Kb
  • Complement factor: C5 normal
  • Susceptible to the development of atheromatous lesion after 20 weeks on high fat diets.
  • Develops non-insulin dependent diabetes mellitus and hypertension when fed a high fat, high simple carbohydrate diet.
  • Glucose intolerance is due to spontaneous mutation in Nicotinamide Nucleotide Transhydrogenase (Nnt).
  • Generally refectory to many tumours and to many infectious agents.
  • Congenital abnormalities include microphthalmia, corneal opacities, anophthalmia and hydrocephalus.
  • Susceptible to imperforate vaginas and mucometra.
  • White spotting commonly observed in pigmentation.
  • Aggressiveness observed in male from 6 weeks of age and female breeders.
  • Fighting amongst males increases when cohorts are divided into smaller groups.
  • Barbering and ulcerative dermatitis observed.
  • The C57BL/6J inbred strain was created by Dr. CC Little from the mating of female 57 with male 52 from Miss Abbie Lathrop’s stock.
  • Ozgene ARC received the stock strain from ARC in 2023.
  • B6 mice is the most widely used inbred strain and the first to have its genome sequenced.

Past ARC and transfer reports:

Current Ozgene ARC reports (from 01-Jun-2023)

  • Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.