Common name B6
Synonyms B6J, B6/J, Black6
Coat Colour Black (a/a)
JAX stock number 000664
Location Area Oz2, Oz3, Oz5
MHC haplotype: H2K
b Complement factor: C5 normal
Susceptible to the development of atheromatous lesion after 20 weeks on high fat diets.
Develops non-insulin dependent diabetes mellitus and hypertension when fed a high fat, high simple carbohydrate diet.
Glucose intolerance is due to spontaneous mutation in Nicotinamide Nucleotide Transhydrogenase (Nnt).
Generally refectory to many tumours and to many infectious agents.
Congenital abnormalities include microphthalmia, corneal opacities, anophthalmia and hydrocephalus.
Susceptible to imperforate vaginas and mucometra.
White spotting commonly observed in pigmentation.
Aggressiveness observed in male from 6 weeks of age and female breeders.
Fighting amongst males increases when cohorts are divided into smaller groups.
Barbering and ulcerative dermatitis observed.
The C57BL/6J inbred strain was created by Dr. CC Little from the mating of female 57 with male 52 from Miss Abbie Lathrop’s stock.
Ozgene ARC received the stock strain from ARC in 2023.
B6 mice is the most widely used inbred strain and the first to have its genome sequenced.
Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.