C57BL/6JOzarc
Strain description
- MHC haplotype: H2Kb
- Complement factor: C5 normal
- Susceptible to the development of atheromatous lesion after 20 weeks on high fat diets.
- Develops non-insulin dependent diabetes mellitus and hypertension when fed a high fat, high simple carbohydrate diet.
- Glucose intolerance is due to spontaneous mutation in Nicotinamide Nucleotide Transhydrogenase (Nnt).
- Generally refectory to many tumours and to many infectious agents.
- Congenital abnormalities include microphthalmia, corneal opacities, anophthalmia and hydrocephalus.
- Susceptible to imperforate vaginas and mucometra.
- White spotting commonly observed in pigmentation.
- Aggressiveness observed in male from 6 weeks of age and female breeders.
- Fighting amongst males increases when cohorts are divided into smaller groups.
- Barbering and ulcerative dermatitis observed.
- The C57BL/6J inbred strain was created by Dr. CC Little from the mating of female 57 with male 52 from Miss Abbie Lathrop’s stock.
- Ozgene ARC received the stock strain from ARC in 2023.
- B6 mice is the most widely used inbred strain and the first to have its genome sequenced.
Past ARC and transfer reports:
Current Ozgene ARC reports (from 01-Jun-2023)
- Please see on our Biosecurity page
- These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: JAX General Terms and Conditions
- JAX mice are the gold standard for animal model research.
- Ozgene ARC terms and Conditions
- Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.
