F344

Strain descriptions

MHC Haplotype RT1^lv1
The most popular strain of rat for use in carcinogen evaluation
Relatively low incidence of naturally occurring neoplasms.
High responder to induced neoplasms via chemicals and/or irradiation.
Glandular changes associated with the spontaneous interstitial cell tumours of the testis.
Resistant to spontaneous autoimmune thyroiditis.
Low incidence of nephritis.
Good breeding performance.
Young females are jumpy and don’t like being handled.

Received as Germ Free animals from Charles River Breeding Laboratories, USA (1983).
Charles River rederived F68 from NIH in 1960 to SPF status, NIH received as F51 (1950) from Heston. Heston from Columbia University, USA (1949). Originally developed as an inbred by Curtis (1920) at Columbia University Institute for Cancer Research, USA.
Received from Animal Resource Centre (ARC), Western Australia in 2023.

General multipurpose model, aging, safety and efficacy testing, surgical model, oncology, nutrition.

Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.

J Kanno , C Matsuoka, K Furuta, H Onodera, A Maekawa, Y Hayashi (1987) Glandular changes associated with the spontaneous interstitial cell tumor of the rat testes. 15(4):439-43.