|Synonyms||FVB/NJ, Friend Virus B NIH Jackson, FVB/N, FVBN|
|Coat colour||Albino (A/A Tyrc/Tyrc)|
|JAX stock number||001800|
- MCH haplotype: H2Kq
- Complement factor: C5 deficient
- FVB/NJ mice are known for their large and prominent pronuclei in fertilized eggs, which makes them useful for production of transgenic mice through microinjections.
- They exhibit higher than average activity, anxiety, and basal body temperature, as well as low stress-induced hyperthermia.
- They are also known to exhibit aggression, particularly in male stock from 6 weeks of age.
- FVB/NJ mice have a low incidence of lymphomas but may develop lung tumors.
- Some sublines of FVB/NJ mice may exhibit neuropathological conditions, such as seizures and neuronal necrosis in cerebral cortical and hippocampal neurons.
- FVB/NJ mice were initially derived from outbred Swiss mice at the National Institutes of Health (NIH) in 1966, which were selectively bred for either resistance or sensitivity to histamine challenge post pertussis vaccination.
- At the eighth generation of inbreeding (in the early 1970s), the sensitive line, HSFS/N, was found to carry the Fv1b allele which confers sensitivity to the Friend leukemia virus B strain. The FVB/N strain resulted from inbreeding this line for the Fv1b allele.
- FVB/NJ mice are commonly used in research studies related to transgenic mouse production, behaviour, neuropathology, and immunology. Their large and prominent pronuclei in fertilized eggs facilitate microinjections, making them a valuable strain for generating transgenic mice.
- These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: JAX General Terms and Conditions
JAX mice are the gold standard for animal model research
- Ozgene ARC terms and Conditions
- Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.