goGermline knockout & knock-in mice
17 July'17 - The inaugural ISTT 3Rs prize winner is… the goGermline technology
"The potentially significant impact that the widespread application and use of this transgenic technology provides, makes it a worthy inaugural winner of the ISTT 3Rs prize, the aim of which is to raise awareness of the beneficial 3Rs impact that transgenic technologies can have in relation to the use of animals for scientific research."
Our Principal Scientist in North America, Dr. Roger Askew, will give a presentation and accept the award during the Ethics & 3Rs session at TT2017 in Salt Lake City, Utah, 1-4 Oct'17.
25 Mar'16 - goGermline paper published in genesis
Genesis. 2016 Jun;54(6):326-33. doi: 10.1002/dvg.22938. Epub 2016 May 18.
Exclusive transmission of the embryonic stem cell-derived genome through the mouse germline.
Koentgen F, Lin J, Katidou M, Chang I, Khan M, Watts J, Mombaerts P.
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What is goGermline?
goGermline is a fast and efficient way to generate knockout and knock-in mice. It is a revolutionary technology that incorporates the use of goGermline blastocysts for injecting embryonic stem (ES) cells. goGermline eliminates competition with “host” blastocysts, resulting in 100% ES cell derived offspring.
Ozgene is the only company that can guarantee that only ES cell derived animals are produced at chimera breeding. All of our knockout and knock-in projects use goGermline, with significant benefits to germline efficiency, project timelines and animal welfare. goGermline is also an ideal way to generate mice from KOMP & EUCOMM targeted ES cells.
Watch the video to learn more about goGermline and its benefits to investigators and animal welfare.
Contact us to discuss your goGermline project or licensing of goGermline.
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