Humanised Models
GENETICALLY MODIFIED MICE FOR RESEARCH
Humanised mouse models
in fastest times
- Human genomic replacement of any size gene
- Fastest industry timelines enabled by our goGermline™
award winning technology - Total lowest cost
- Real-time project status portal and notifications
- Own your IP, customised mouse models and all the reagents
Get a quote from us.
GENETICALLY MODIFIED MICE FOR RESEARCH
Humanised mouse models in
fastest times
- Human genomic replacement of any size gene
- Fastest industry timelines enabled by our goGermline™
award winning technology - Total lowest cost
- Real-time project status portal and notifications
- Own your IP, customised mouse models and all the reagents
Get a quote from us.
+500
publications
+2k
projects
+30 years of
knowledge
+NYSE, NASDAQ
listed partners
+Top tier academic
partners
+70% repeat
business
NO PROJECT QUEUES WITH goGermline™
How long does it
take to generate
humanised mouse models?
A revolutionary technology for generating gene-targeted humanised mice. Germline transmission is achieved faster and more efficiently with no excess mice, expediting time to first experimental transgenic mice.
NO PROJECT QUEUES WITH goGermline™
How long does it take to generate humanised mouse models?
A revolutionary technology for generating gene-targeted humanised mice. Germline transmission is achieved faster and more efficiently with no excess mice, expediting time to first experimental transgenic mice.
- ✓ Any gene, any size
- ✓ Fastest possible time to first experiment
- ✓ Humanize whole genes
- ✓ Increase germline transmission efficiency
- ✓ Any gene, any size
- ✓ Fastest possible time to first experiment
- ✓ Increase germline transmission efficiency
- ✓ Humanize whole genes
GETTING YOUR PROJECT STARTED
How to get your
humanised
mouse model
Each humanisation project is based on your requirements and we will assess your gene of interest to find the most appropriate approach.
-
STEP 1
Submit your details above -
STEP 2
We will reach out for details on your objective -
STEP 3
We will provide you a design and quote
GETTING YOUR PROJECT STARTED
How to get your humanised mouse model
Each humanisation project is based on your requirements and we will assess your gene of interest to find the most appropriate approach.
-
STEP 1
Submit your details above -
STEP 2
We will reach out for details on your objective -
STEP 3
We will provide you a design and quote
FAQ
Questions?
- We have no project queues.
- Ozgene’s highly efficient project pipeline allows us to start projects without lengthy waiting periods.
- Your project will start as soon as Ozgene receives a signed contract and a purchase order.
- Get starting by requesting a free quote!
- Ozgene generates mouse models via gene targeting in ES cells using our proprietary goGermline™ technology, which vastly improves the 3R efficiencies and the timeline for development of gene targeted mouse models.
- We also use various technologies to validate and phenotype your mouse lines e.g. RT-qPCR, Western Blot, ELISA and flow cytometry.
- Ozgene is able to create large, gene-targeted replacement models. This system enables routine generation of mouse models with very large genomic replacements.
Ozgene offers gene targeting on the following backgrounds:
- C57BL/6J
- C57BL/6N
- BALB/c
- FVB/n
- NOD
- Less common strains as required
We generate genetically engineered humanised models where the human gene replaces the mouse gene, for example
- humanising point mutations,
- humanising domains, such as extracellular domains,
- humanising the entire gene,
- humanising multi-gene loci.
- Knock in mice
- Knock out mice
- Conditional knockout mice (or floxed mice)
- Other transgenic mice
- Predictable Phenotypes: Targeted modifications result in predictable phenotypes, making it easier to understand the role of specific genes in disease and assess the impact of potential drugs.
- Improved Model Validity: By closely mimicking human genetic conditions, targeted transgenic mice provide more accurate models for studying human diseases and drug responses.
- Reduced Risk of Unintended Effects: The precision of targeted integration reduces the risk of unintended genetic effects, ensuring that observed drug responses are due to the intended gene modifications.
- We have no project queues.
- Ozgene’s highly efficient project pipeline allows us to start projects without lengthy waiting periods.
- Your project will start as soon as Ozgene receives a signed contract and a purchase order.
- Get starting by requesting a free quote!
- Ozgene generates mouse models via gene targeting in ES cells using our proprietary goGermline™ technology, which vastly improves the 3R efficiencies and the timeline for development of gene targeted mouse models.
- We also use various technologies to validate and phenotype your mouse lines e.g. RT-qPCR, Western Blot, ELISA and flow cytometry.
- Ozgene is able to create large, gene-targeted replacement models. This system enables routine generation of mouse models with very large genomic replacements.
Ozgene offers gene targeting on the following backgrounds:
- C57BL/6J
- C57BL/6N
- BALB/c
- FVB/n
- NOD
- Less common strains as required
We generate genetically engineered humanised models where the human gene replaces the mouse gene, for example
- humanising point mutations,
- humanising domains, such as extracellular domains,
- humanising the entire gene,
- humanising multi-gene loci.
- Knock in mice
- Knock out mice
- Conditional knockout mice (or floxed mice)
- Other transgenic mice
- Predictable Phenotypes: Targeted modifications result in predictable phenotypes, making it easier to understand the role of specific genes in disease and assess the impact of potential drugs.
- Improved Model Validity: By closely mimicking human genetic conditions, targeted transgenic mice provide more accurate models for studying human diseases and drug responses.
- Reduced Risk of Unintended Effects: The precision of targeted integration reduces the risk of unintended genetic effects, ensuring that observed drug responses are due to the intended gene modifications.
