K-18 hACE2

K-18 hACE2

K18-hACE2

Strain details
NomenclatureB6.Cg-Tg(K18-ACE2)2Prlmn/JOzarc
Common nameK18-hACE2
SynonymsACE2
StrainTransgenic
Coat ColourBlack
SpeciesMouse
Genetic background-
JAX stock number034860
LocationArea Oz3

Strain descriptions

  • K18-hACE2 transgenic mice express human ACE2, the receptor used by severe acute respiratory syndrome coronavirus (SARS-CoV) to gain cellular entry.
  • This model of infection with SARS-CoV mimics the human SARS disease.
  • These mice should be handled in a manner consistent with CDC/ABSA/WHO guidelines for prevention of human infection with the SARS-CoV-2 virus.
  • Proper PPE and handling methods should be used at all times when working with these mice.
  • Homozygous K18-hACE2 mice are available.
  • K18-hACE2 transgenic mice are imported from JAX to Animal Resource Centre (ARC) Australia in 2020.
  • This strain is transferred to Ozgene ARC in 2023.
  • K18-hACE2 are susceptible to SARS-CoV-2 and SARS-CoV viruses, they are useful for studying antiviral therapies to COVID-19 and SARS.
  • These mice should be handled in a manner consistent with CDC/ABSA/WHO guidelines for prevention of human infection with the SARS-CoV-2 virus. Proper PPE and handling methods should be used at all times when working with these mice.

Past ARC and transfer reports:

Current Ozgene ARC reports (from 01-Jun-2023)

  • Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.
  • Oladunni FS, Park JG, Pino PA, Gonzalez O, Akhter A, Allué-Guardia A, Olmo-Fontánez A, Gautam S, Garcia-Vilanova A, Ye C et al. 2020. Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice. Nat Commun. 2020 Nov 30;11(1):6122. doi: 10.1038/s41467-020-19891-7. PMID: 33257679
  • Zheng J, Wong LYR, Li K, Verma AK, Ortiz ME, Wohlford-Lenane C, Leidinger MR, Knudson CM, Meyerholz DK, McCray Jr. PB, Perlman S 2021. COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Nature. 2021 Jan;589(7843):603-607. doi: 10.1038/s41586-020-2943-z. PMID: 33166988
  • Zumla A, Chan JFW, Azhar EI, Hui DSC, Yuen KY 2016. Coronaviruses – drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. doi: 10.1038/nrd.2015.37. PMID: 26868298