- MHC haplotype:
- The Dmdmdx strain is a mouse model of Duchenne muscular dystrophy (DMD), a genetic disorder causing muscle weakness.
- These mice have a mutation in the dystrophin gene, leading to the absence of functional dystrophin protein.
- The mdxmutation of Dmd is sex-linked recessive and heterozygous females are visually indistinguishable from wild-type mice. Females homozygous and males hemizygous for the Dmdmdx allele retain a normal lifespan and can survive up to two years.
- Dmdmdx strain may exhibit cystitis and congenital abnormalities such as microphthalmia, corneal opacities, and hydrocephalus.
- Despite muscle pathology, Dmdmdx mice behave normally in terms of locomotor activity and general behaviour.
- Strain received from Australian Neuromuscular Research Institute in 1997 from Dr. Sue Fletcher.
- The Dmdmdx strain is a unique mouse model of DMD, showing atypical phenotypic characteristics compared to other DMD models. It could be valuable for studying the role of dystrophin in muscle and other organ systems, as well as compensatory mechanisms that allow for normal behaviour despite muscle pathology.
- Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.