NOD

NOD

NOD

Strain details
Nomenclature NOD/ShiLtJOzArc
Common nameNOD
SynonymsNon-obese Diabetic, NOD/LtJ
StrainInbred
Coat colourAlbino (A/A Tyrc/Tyrc)
SpeciesMouse
JAX stock number001976
LocationArea Oz2
Weekly wean target20 males, 50 females

Strain description

  • MHC haplotype: H2Kg7
  • Complement factor: C5 deficient
  • The Jackson Laboratory reports that diabetes occurs in 90-100% of females by 30 weeks of age and 40-60% of males by 30-40 weeks of age.
  • Susceptibility to diabetes is polygenic and environment factors such as housing conditions, health status and diet exert a strong effect on penetrance.
  • Females produce 4 to 5 litters before becoming diabetic.
  • Female breeders are aggressive.
  • The incidence of diabetes in males is influenced by environmental factors including pathogens in an inverse relationship i.e. higher incidence of diabetes in germfree animals than conventional animals.
  • Mice free from diabetes by 1 year are prone to develop follicle centre cell lymphomas.
  • Important Note: This strain is homozygous for Cdh23ahl, the age-related hearing loss 1 mutation, which on this background results in progressive hearing loss that is already severe by three months of age.
  • Strain was formerly called NOD/LtJ until 2007 when it was changed to NOD/ShiLtJ
  • This strain was transferred from ARC to Ozgene ARC in 2023.
  • This strain is used in immunology and inflammation research and is a polygenic model for type 1 diabetes.

Past ARC and transfer reports:

Current Ozgene ARC reports (from 01-Jun-2023)

  • Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.