NSG

Strain details
Nomenclature	NOD.Cg-Prkdc^scid ll2rg^tm1Wjl /SzJ/Ozarc
Common name	NSG
Synonyms	NOD-scid IL2Rgamma^null, NOD-scid IL2Rg^null,NOD scid gamma
Strain	Congenic, Spontaneous mutation, Targeted mutation
Coat colour	Albino (A/A Tyr^c /Tyr^c )
Species	Mouse
Genetic background	NOD/ShiLtJ
JAX stock number	005557
Location	Area Oz1

Strain descriptions

MHC haplotype: H2K^g7
NSG mice do not express the Prkdc gene nor the X-linked Il2rg gene.
The mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
NSG mice lack mature T cells, B cells, or functional NK cells, and are deficient in cytokine signaling, leading to better engraftment of human hematopoietic stem cells and peripheral-blood mononuclear cells than any other published mouse strain.
NSG mice exhibit a progressive hearing loss that is already severe by three months of age. Due to their level of immunodeficiency NSG mice need to be maintained in a ‘maximum barrier’.
This strain is only available for Australian and New Zealand researchers.

These double mutant mice were produced by breeding female NOD.CB17- Prkdc^scid /J mice with male mice bearing the X-linked B6.129S4-Il2rg^tm1Wjl /J allele. The resulting male mice heterozygous for the Prkdc^scid allele and hemizygous for the Il2rg^tm1Wjl allele were crossed to female NOD.CB17- Prkdc^scid /J mice for eight generations.
Heterozygotes were interbred to produce mice homozygous for the Prkdc^scid allele and homozygous (females) or hemizygous (males) for the Il2rg^tm1Wjl allele.
NSG strain is imported from JAX into Animal Resource Centre (ARC) in 2021.
The stock strain is transferred to Ozgene ARC in 2023.

Recent publications have demonstrated this strain’s outstanding utility in the studies of islet transplantation, hematopoietic stem cells and cancer stem cells.

These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: JAX General Terms and Conditions.
JAX mice are the gold standard for animal model research.
Ozgene ARC terms and Conditions

Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.