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A direct method for the formation of peptide and carbohydrate dendrimers.

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1999

Bioorg Med Chem Lett 1999 Oct 4;9(19):278

A direct method for the formation of peptide and carbohydrate dendrimers.

Koentgen, F;Lambert, JN.;Langley, J;Mitchell, JP;Roberts, KD

School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia.

Service type: Not applicable

Abstract

Two new methods for the modification of PAMAM dendrimers have been developed which allow the covergent synthesis of either peptide or carbohydrate-bearing dendrimer molecules. Both methods involve condensation between hydroxylamino nucleophiles and appropriate carbonyl-bearing reaction partners.

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