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Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.

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2015

Nat Commun. 2015 Apr 20;6:6804. doi: 10.1038/ncomms7804.

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.

J Li;SF Jørgensen;SM Maggadottir;M Bakay;K Warnatz;J Glessner;R Pandey;U Salzer;RE Schmidt;E Perez;E Resnick;S Goldacker;M Buchta;T Witte;L Padyukov;V Videm;T Folseraas;F Atschekzei;JT Elder;RP Nair;J Winkelmann;C Gieger;MM Nöthen;C Büning;S Brand;KE Sullivan;JS Orange;B Fevang;S Schreiber;W Lieb;P Aukrust;H Chapel;C Cunningham-Rundles;A Franke;TH Karlsen;B Grimbacher;H Hakonarson;L Hammarström;E Ellinghaus

Children's Hospital of Philadelphia & University of Pennsylvania, PA, USA. Oslo University Hospital, Norway. University of Freiburg, Germany. Hannover Medical School, Germany. University of Miami Miller School of Medicine, FL, USA. Mount Sinai School of Medicine, New York, NY, USA. Karolinska Institutet, Stockholm, Sweden. Norwegian University of Science and Technology, Trondheim, Norway. University of Michigan, Ann Arbor, MI, USA. German Research Center for Environmental Health, Neuherberg, Germany. Technische Universität München, Germany. Stanford Center for Sleep Sciences and Medicine, Palo Alto, CA, USA. University of Bonn, Germany. Charité, Berlin, Germany. University Hospital Munich-Grosshadern, Munich, Germany. Texas Children's Hospital, Houston, TX, USA. Christian-Albrechts-University, Kiel, Germany. University of Oxford, UK. Karolinska University Hospital, Huddinge, Sweden.

Service type: Knockout mice

Abstract

Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency in adults, characterized by B-cell abnormalities and inadequate antibody response. CVID patients have considerable autoimmune comorbidity and we therefore hypothesized that genetic susceptibility to CVID may overlap with autoimmune disorders. Here, in the largest genetic study performed in CVID to date, we compare 778 CVID cases with 10,999 controls across 123,127 single-nucleotide polymorphisms (SNPs) on the Immunochip. We identify the first non-HLA genome-wide significant risk locus at CLEC16A (rs17806056, P=2.0 × 10(-9)) and confirm the previously reported human leukocyte antigen (HLA) associations on chromosome 6p21 (rs1049225, P=4.8 × 10(-16)). Clec16a knockdown (KD) mice showed reduced number of B cells and elevated IgM levels compared with controls, suggesting that CLEC16A may be involved in immune regulatory pathways of relevance to CVID. In conclusion, the CLEC16A associations in CVID represent the first robust evidence of non-HLA associations in this immunodeficiency condition.

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