Role of STAT1 in the breast.

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JAKSTAT. 2012 Jul 1;1(3):197-9. doi: 10.4161/jkst.20967.

Role of STAT1 in the breast.

SG Bailey;MS Cragg;PA Townsend

Cancer Sciences Unit; Cancer Research UK Centre; Faculty of Medicine; University of Southampton; Southampton General Hospital; Southampton, UK.

Service type: Knockout mice


Signal transducer and activator of transcription-1 (STAT1) plays a role in the transduction of stress and cytokine responses, DNA damage, and activation of B and T cell immune responses. The ability of STAT1 to act as a pro- or anti-apoptotic signaling molecule depends upon the cellular environment and stimulus. Post-translational modifications provide the main method of control over the function of STAT1, however, recent data in the breast has shown that loss of STAT1 from both the tumor and the surrounding mammary epithelium greatly influence the development and response to treatment of breast cancers. Here, we discuss the recent findings of Chan et al. in Breast Cancer Research who described a new role for STAT1 in the development of estrogen receptor (ER)-positive and progesterone receptor (PR)-positive luminal breast cancers.

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