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Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome.

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2016

Mol Neurobiol. 2016 Sep;53(7):4874-82. doi: 10.1007/s12035-015-9408-7. Epub 2015 Sep 11.

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome.

E Alcocer-Gómez;C Ulecia-Morón;F Marín-Aguilar;T Rybkina;N Casas-Barquero;J Ruiz-Cabello;B Ryffel;L Apetoh;F Ghiringhelli;P Bullón;JA Sánchez-Alcazar;AM Carrión;MD Cordero

Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC-Junta de Andalucía and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, 41013, Sevilla, Spain. Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide de Sevilla, Carretera de Utrera Km. 1, 41013, Sevilla, Spain. Research Laboratory, Dental School, University of Sevilla, Sevilla, Spain. Dpto. Psiquiatría, Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain. CIBER de Enfermedades Respiratorias, Madrid, Spain; Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares and Universidad Complutense Madrid, Madrid, Spain. CNRS, UMR7355, Orléans, France. INSERM, UMR866, Dijon, France. Centre Georges François Leclerc, Dijon, France. Université de Bourgogne, Dijon, France. Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide de Sevilla, Carretera de Utrera Km. 1, 41013, Sevilla, Spain. Research Laboratory, Dental School, University of Sevilla, Sevilla, Spain. IBiS Institute of Biomedicine of Seville, University Hospital Virgen del Rocío-CSIC-University of Seville Spain, Sevilla, Spain.

Service type: Knock-in mice

Abstract

Depression is a major public health concern in modern society, yet little is known about the molecular link between this condition and neuroinflammation. The inflammasome complex was recently shown to be implicated in depression. The present study shows the implication of NLRP3 inflammasome in animal model of stress-induced depression. Accordingly, we show here that in the absence of a NLRP3 inflammasome, prolonged stress does not provoke depressive behaviors or microglial activation in mice or dampen hippocampal neurogenesis. Indeed, NLRP3 deletion or inhibition of microglial activation impairs the stress-induced alterations associated with depression. According to these findings in animal model, the inflammasome could be a target for new therapeutic interventions to prevent depression in patients.

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