PVG/c

Strain details
Nomenclature	PVG/cOzarc
Common name	PVG/c
Synonyms	PVG
Strain	Inbred
Coat colour	White with black hood (a, B, C, h)
Species	Rat
Genetic background	-
Location	Vivarium 4
Supply	Tier 2: pre-allocation, breed on request

Strain description

MHC Haplotype RT1^c
Animals are docile and has very good breeding performance.
Popular inbred for general use as low activity relative to other strains.
Resistant to experimental allergic encephalomyelitis and the induction of autoimmune thyroiditis.
Useful model for development of autoimmune thyroiditis and diabetes due to insulitis following thymectomy and sublethal x-irradiation.

Originally inbred by Glaxo, UK (1946) from stock originating from King College of Household Science to Lister Institute, to Virol to Glaxo (P = Piebald, V = Virol, G = Glaxo, C = ARC Compton where a recognised subline developed). CSIRO from Glaxo, UK.
To Murdoch University from John Curtin School of Medical Research, Canberra, Australia as F13+ (1976). JCSMR from CSIRO, NSW Australia as F20 (1970).
Animal Resource Centre (ARC), Western Australia received stock strain from Murdoch University, Perth, Australia as F12 (1981). Caesarean derived to SPF status (1981).
Strain is transferred to Ozgene ARC in 2023.

Application: Useful model for development of autoimmune thyroiditis and diabetes due to insulitis following thymectomy and sublethal x-irradiation.

Past ARC reports:

Current Ozgene ARC reports (from 01-Jun-2023)

Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.