Wistar Kyoto

Strain descriptions

MHC haplotype: RT1^l
Adult WKY have an inability to excrete acid appropriately after acute or chronic acid loading compared to Sprague Dawley rats.
A subset of WKY originating at NIH demonstrates an inheritable transmission of biventricular cardiac hypertrophy (BVH).
WKY with BVH provide a natural model of volume load hypertrophy.
Recognised normotensive control to use in parallel with studies involving the hypertensive SHR rat.

Originally from the outbred Wistar colony at the Kyoto School of Medicine from which the spontaneous hypertensive rat SHR was selected and inbred (note SHR/N). Maintained as a normotensive control to evaluate against the hypertensive SHR strain.
NIH received non-inbred Wistar stock from Kyoto School of Medicine, Japan (1971). NIH established the rat as an inbred Wistar colony via brother x sister mating (1971).
Flinders University from NIH, USA as F14 (1976).
Received to ARC from the School of Medicine, Flinders University, South Australia as F12 (1983). Caesarean derived to SPF status (1983).
Wistar Kyoto was transferred from ARC to Ozgene ARC in 2023.