Can you see the target?

Can you see the target?

Can you see the target?

In this issue

– Feature
– Latest publications
– Updates

Colourblind MouseCan you see the target?

Most people take the ability to see colour for granted. This is not the case for the 8-10% of males and 0.5% of females that are red-green colour-blind. According to Dr Maureen Neitz, a Professor of Ophthalmology at the University of Washington, red-green colour-blindness is generally not considered to be a debilitating visual disorder, however, many affected individuals would disagree.

Dr Neitz’s lab has focused on discovering the genetic basis for normal vision and vision disorders. In her most recent publication, Dr Neitz features a mouse model developed by Ozgene that can be used to study disease variants of human L/M opsins. The L and M opsins refer to the red and green photoreceptors within the retina. Red-green colour-blindness is usually caused by a mutation in these opsins.

Most of Dr Neitz’s career has involved trying to help those who suffer from colour-blindness. She also assisted in the development of a quick and inexpensive way to screen for colour vision deficiencies at schools around the world.

Dr Neitz’s gene therapy project was also featured in an award-winning film series “Cracking the Colour Code” produced by Electric Pictures, located in Perth, Western Australia, which is also Ozgene’s home town. Click on the link below to view the trailer.

To find out more about Dr Neitz and her exciting work, please visit the Neitz Color Vision website or view her most recent publication below.

To read more about Ozgene mouse models, visit the Ozgene website.

Our customers publish more often

An Ozgene mouse model is published every 12 days, with over 200 research papers published by our clients utilising Ozgene mouse models, 124 of them in the past 4 years. Please see the latest publications and testimonials from our customers below.

Visual Neuroscience. 2014 Jan 1.
S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.
Greenwald SH, Kuchenbecker JA, Roberson DK, Neitz M, Neitz J. Vision Sciences, University of Washington, Seattle, WA, USA. [read]

“I received constant feedback complete with gel images and experimental design, discussion of difficulties encountered so I felt I always knew what was going on with the project as if it were happening in my own lab.”

– Dr Maureen Neitz, University of Washington, USA

Epilepsia. 2014 Mar 7.
Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy.
Hatch RJ, Reid CA, Petrou S. Florey Institute of Neuroscience and Mental Health, Melbourne, Australia. [read]

“The NaVβ1(C121W) mouse model generated by Ozgene has been instrumental in revealing pathogenic mechanisms in human genetic epilepsy.”

– Dr Steven Petrou, Howard Florey Institute, Australia

J Renin Angiotensin Aldosterone Syst. 2014 Feb 14.
Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages.Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages.
Nikolaou A, Stijlemans B, Laoui D, Schouppe E, Tran HT, Tourwé D, Chai SY, Vanderheyden PM, Van Ginderachter JA. Vrije Universiteit Brussel, Belgium. [read]

Am J Respir Crit Care Med. 2014 Feb 7.
Transforming Growth Factor β-induced Protein Promotes Severe Vascular Inflammatory Responses.
Bae JS, Lee W, Nam JO, Kim JE, Kim SW, Kim IS. Kyungpook National University, Daegu, Republic of Korea. [read]

Go to papers

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Did you know?

Since 1999, Ozgene has undertaken over 1000 knockout and knockin mouse projects, with germline transmission achieved for all projects to date, including double targeting. See a list of successful publications on the Ozgene website.

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