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2025

Metabolism. 2025 Nov:172:156358. doi: 10.1016/j.metabol.2025.156358. Epub 2025 Aug 5.

A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity

Christine Mund, Anupam Sinha, Anika Aderhold, Ivona Mateska, Eman Hagag, Sofia Traikov, Bettina Gercken, Andres Soto, Jonathan Pollock, Lilli Arndt, Michele Wölk, Natalie Werner, Georgia Fodelianaki, Pallavi Subramanian, Kyoung-Jin Chung, Sylvia Grossklaus, Mathias Langner, Mohamed Elgendy, Tatyana Grinenko, Ben Wielockx, Andreas Dahl, Martin Gericke, Matthias Blüher, Ünal Coskun, David Voehringer, Maria Fedorova, Mirko Peitzsch, Peter J Murray, Triantafyllos Chavakis, Vasileia Ismini Alexaki

Service type: Knock-in mice

2025

Brain Behav Immun. 2025 Nov:130:106099. doi: 10.1016/j.bbi.2025.106099. Epub 2025 Sep 3.

Comparing two anti-inflammatory reflexes: Splanchnic and hypothalamic-pituitary-adrenal

Michael McKinley, Song T Yao, Davide Martelli, Robin McAllen

Service type: Stock strains

2025

Am J Physiol Cell Physiol. 2025 Nov 1;329(5):C1498-C1510. doi: 10.1152/ajpcell.00230.2025. Epub 2025 Oct 3.

Cachexia progression differs among mouse models of metastatic triple-negative breast cancer

Alastair A E Saunders, Chris Karagiannis, Wayne X Du, Lauren S James, Rachel E Thomson, Robin L Anderson, Paul Gregorevic

Service type: Stock strains

2025

Sci Adv. 2025 Oct 17;11(42):eadz1726. doi: 10.1126/sciadv.adz1726. Epub 2025 Oct 17.

Lyn restrains lupus via kinase-independent mechanisms that limit Toll-like receptor activation and type I interferon responsiveness

Elan L'Estrange-Stranieri, Timothy A Gottschalk, Anne M Kong, Mhairi J Maxwell, Ee Shan Pang, Evelyn Tsantikos, David M Tarlinton, Meredith O'Keeffe, Mark D Wright, Margaret L Hibbs

Service type: Knock-in mice

2025

Mol Ther. 2025 Oct 11:S1525-0016(25)00842-1. doi: 10.1016/j.ymthe.2025.10.021. Online ahead of print.

Pancreatic transdifferentiation of NOD mouse livers prevented development of hyperglycemia

Alexandra L G Mahoney, Binhai Ren, Najah T Nassif, Bronwyn A O'Brien, Grant J Logan, Catherine A Gorrie, Ian E Alexander, Ann M Simpson

Service type: Stock strains

2025

J Control Release. 2025 Oct 10:386:114143. doi: 10.1016/j.jconrel.2025.114143. Epub 2025 Aug 19.

Gut microbial diversity is preserved through localised chemo-immunotherapy delivery in a KPC mouse model of pancreatic cancer

Elahe Minaei, Paul Joyce, Samantha J Wade, Christopher Brownlee, Chelsea Penney, Marie Ranson, Morteza Aghmesheh, Ronald Sluyter, Kara L Vine-Perrow

Service type: Stock strains

2025

J Control Release 2025 Oct 9;388(Pt 1):114299. doi: 10.1016/j.jconrel.2025.114299. Online ahead of print.

Polymeric-lipid nanoparticles that leverage cationic helper lipids and the protein corona for lung-targeted delivery of a novel anti-cancer drug

Santhni Subramaniam, Leigh Donnellan, Anthony Wignall, Joanna Woodcock, Carl Coolen, Stuart Pitson, Ali Taheri, Clifford Young, Peter Hoffmann, Clive A Prestidge, Paul Joyc

Service type: Stock strains

2025

JCI Insight. 2025 Sep 9;10(20):e193733. doi: 10.1172/jci.insight.193733. eCollection 2025 Oct 22.

Rac1 palmitoylation is required for cardiac stress adaptation and regulation of protein kinase A signaling

James P Teuber, Rachel E Scissors, Arasakumar Subramani, Nageswara Madamanchi, Matthew J Brody

Service type: Knock-in mice

2025

Commun Biol. 2025 Aug 29;8(1):1302. doi: 10.1038/s42003-025-08763-9.

Stress-inducible phosphoprotein 1 (STIP1) is a critical stemness regulator in mouse embryonic stem cells and early mammalian development

Camila Felix de Lima Fernandes, Marilene Hohmuth Lopes, Maria Clara da Silva Souza, Samuel Ribeiro Soares, Jenny Andrea Arévalo-Romero, Rachel E Lackie, Bárbara Paranhos Coelho, João Pedro Alves de Araújo, Jacqueline Marcia Boccacino, Rebeca Piatniczka Iglesia, Maria Isabel Melo-Escobar, Mariana Brandão Prado, Marcelo Falchetti, Frederico Moraes Ferreira, Helder Nakaya, Tiago Góss Dos Santos, Edroaldo Lummertz da Rocha, Flávio H Beraldo, Vania F Prado, Marco A M Prado

Service type: Stock strains

2025

J Exp Clin Cancer Res. 2025 Aug 14;44(1):239. doi: 10.1186/s13046-025-03502-8.

Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma

Kimberley M Hanssen, Jayne Murray, Ruby Pandher, Stephanie Alfred, Laura D Gamble, Jennifer Brand, Erin Mosmann, Frances K Kusuma, Crystal Mak, Adam Kearns, Alvin Kamili, Caroline Atkinson, Alexis Z Minchaca, Jean Bertoldo, David S Ziegler, Francis Mussai, Paul N M Cheng, Murray D Norris, Jamie I Fletcher, Michelle Haber

Service type: Stock strains

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