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Publications

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2021

Nat Commun. 2021 Jun 18;12(1):3754. doi: 10.1038/s41467-021-23909-z.

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkel, Katrin Nitz, Claudia M van Tiel, Tom T P Seijkens, Pascal J H Kusters, Ela Karshovka, Koen H M Prange, Yuting Wu, Sanne L N Brouns, Sigrid Unterlugauer, Marijke J E Kuijpers, Myrthe E Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T A Megens, Johan W M Heemskerk, Isabel Goncalves, Christian Weber, Norbert Gerdes, Dorothee Atzler, Esther Lutgens

Service type: Knockout mice

2021

J Exp Med. 2021 Jun 7;218(6):e20210008. doi: 10.1084/jem.20210008.

PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling

Jiwen Li, Catharina Conrad, Tingting W Mills, Nathaniel K Berg, Boyun Kim, Wei Ruan, Jae W Lee, Xu Zhang, Xiaoyi Yuan, Holger K Eltzschig.

Service type: Knockout mice

2021

Am J Hematol. 2021 Jun 1;96(6):698-707. doi: 10.1002/ajh.26171. Epub 2021 May 3.

Hematopoietic expression of a chimeric murine-human CALR oncoprotein allows the assessment of anti-CALR antibody immunotherapies in vivo

Sarada Achyutuni, Harini Nivarthi, Andrea Majoros, Eva Hug, Christina Schueller, Ruochen Jia, Cecilia Varga, Michael Schuster, Martin Senekowitsch, Dimitris Tsiantoulas, Anoop Kavirayani, Christoph J Binder, Christoph Bock, Oleh Zagrijtschuk, Robert Kralovics.

Service type: Knock-in mice

2021

Biochem Biophys Res Commun. 2021 Jul 23;563:66-72. doi: 10.1016/j.bbrc.2021.05.063. Epub 2021 May 29.

Comprehensive expression pattern of kin of irregular chiasm-like 3 in the adult mouse brain

Tomoko Hisaoka, Tadasuke Komori, Kohta Fujimoto, Toshio Kitamura, Yoshihiro Morikawa

Service type: Knock-in mice

2021

Mol Psychiatry. 2021 May 7. doi: 10.1038/s41380-021-01139-5. Online ahead of print.

Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice

Xin Li, Hongyu Zhong, Zhongke Wang, Rui Xiao, Per Antonson, Tianyao Liu, Chuan Wu, Jiao Zou, Lian Wang, Ivan Nalvarte, Haiwei Xu, Margaret Warner, Jan-Ake Gustafsson, Xiaotang Fan.

Service type: Knockout mice

2021

Sci Rep. 2021 Apr 29;11(1):9319. doi: 10.1038/s41598-021-88895-0.

Inducible knockout of Clec16a in mice results in sensory neurodegeneration

Heather S Hain, Rahul Pandey, Marina Bakay, Bryan P Strenkowski, Danielle Harrington, Micah Romer, William W Motley, Jian Li, Eunjoo Lancaster, Lindsay Roth, Judith B Grinspan, Steven S Scherer, Hakon Hakonarson

Service type: Knockout mice

2021

Diabetes. 2021 Apr 21;db201121. doi: 10.2337/db20-1121. Online ahead of print.

Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis

Alexandre Picard, Salima Metref, David Tarussio, Wanda Dolci, Xavier Berney, Sophie Croizier, Gwenaël Labouebe, Bernard Thorens.

Service type: Knock-in mice

2021

Int J Mol Sci. 2021 Mar 26;22(7):3409. doi: 10.3390/ijms22073409.

Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease

Christian Griñán-Ferré, Júlia Companys-Alemany, Júlia Jarné-Ferrer, Sandra Codony, Celia González-Castillo, Daniel Ortuño-Sahagún, Lluïsa Vilageliu, Daniel Grinberg, Santiago Vázquez, Mercè Pallàs

Service type: Humanized mice

2021

Cancers (Basel). 2021 Mar 14;13(6):1288. doi: 10.3390/cancers13061288.

p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair

Keane K Y Lai, Xiaohui Hu, Keisuke Chosa, Cu Nguyen, David P Lin, Keith K Lai, Nobuo Kato, Yusuke Higuchi, Sarah K Highlander, Elizabeth Melendez, Yoshihiro Eriguchi, Patrick T Fueger, Andre J Ouellette, Nyam-Osor Chimge, Masaya Ono, Michael Kahn

Service type: Knock-in mice

2021

bioRxiv. 2021 Mar 02. doi: https://doi.org/10.1101/2021.03.01.433470

EHF is essential for epidermal and colonic epithelial homeostasis and suppresses Apc-initiated colonic tumorigenesis

Camilla M. Reehorst, Rebecca Nightingale, Ian Y. Luk, Laura Jenkins, Frank Koentgen, David S. Williams, Charbel Darido, Fiona Tan, Holly Anderton, Michael Chopin, Kael Schoffer, Moritz F. Eissmann, Michael Buchert, Dmitri Mouradov, Oliver M Sieber, Matthias Ernst, Amardeep S. Dhillon, John M. Mariadason

Service type: Knockout mice