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2022

Curr Biol. 2022 Nov 21;32(22):4832-4841.e5. doi: 10.1016/j.cub.2022.09.037. Epub 2022 Oct 10.

Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration

Fengwei Zhang, Sarah O K Mak, Yuchu Liu, Ya Ke, Feng Rao, Wing Ho Yung, Li Zhang, Billy Kwok Chong Chow

Service type: Knockout mice

2022

J Physiol. 2022 Nov;600(22):4827-4848. doi: 10.1113/JP283811. Epub 2022 Oct 19.

Chronic reduction of store operated Ca2+ entry is viable therapeutically but is associated with cardiovascular complications

Fang Yu, Raphael Courjaret, Asha Elmi, Ethel Alcantara Adap, Nelson N Orie, Fawzi Zghyer, Satanay Hubrack, Sajad Hayat, Nidal Asaad, Stefan Worgall, Manikkam Suthanthiran, Vidya Mohamed Ali, Khaled Machaca

Service type: Knock-in mice

2022

Sci Immunol. 2022 Oct 28;7(76):eabm8389. doi: 10.1126/sciimmunol.abm8389. Epub 2022 Oct 28.

Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response

Marcus James Robinson, Mark R Dowling, Catherine Pitt, Kristy O'Donnell, Rosela H Webster, Danika L Hill, Zhoujie Ding, Alexandra R Dvorscek, Erica J Brodie, Philip D Hodgkin, Isaak Quast, David Mathew Tarlinton

Service type: Knock-in mice

2022

Endocrinology 2022 Oct 23;163(12):bqac158. doi: 10.1210/endocr/bqac158.

Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism

Grace Lim, Alexander Widiapradja, Scott P Levick, Kelly J McKelvey, Xiao-Hui Liao, Samuel Refetoff, Martyn Bullock, Roderick J Clifton-Bligh

Service type: Knockout mice

2022

iScience. 2022 Oct 8;25(11):105292. doi: 10.1016/j.isci.2022.105292. eCollection 2022 Nov 18.

KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands

Liyan Fan, Alexander F Lesser, David R Sweet, Komal S Keerthy, Yuan Lu, Ernest R Chan, Vinesh Vinayachandran, Olga Ilkayeva, Tapatee Das, Christopher B Newgard, Mukesh K Jain

Service type: Knockout mice

2022

Dev Cell. 2022 Aug 22;57(16):1957-1975.e9. doi: 10.1016/j.devcel.2022.07.012.

DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential

Bruno Frederico, Isaura Martins, Diana Chapela, Francesca Gasparrini, Probir Chakravarty, Tobias Ackels, Cécile Piot, Bruna Almeida, Joana Carvalho, Alessandro Ciccarelli, Christopher J Peddie, Neil Rogers, James Briscoe, François Guillemot, Andreas T Schaefer, Leonor Saúde, Caetano Reis E Sousa

Service type: Knock-in mice

2022

Immunity. 2022 Aug 17;S1074-7613(22)00354-5. doi: 10.1016/j.immuni.2022.07.019. Online ahead of print.

Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

Marco A Ataide, Konrad Knöpper, Paulina Cruz de Casas, Milas Ugur, Sarah Eickhoff, Mangge Zou, Haroon Shaikh, Apurwa Trivedi, Anika Grafen, Tao Yang, Immo Prinz, Knut Ohlsen, Mercedes Gomez de Agüero, Andreas Beilhack, Jochen Huehn, Mauro Gaya, Antoine-Emmanuel Saliba, Georg Gasteiger, Wolfgang Kastenmüller

Service type: Knock-in mice

2022

Stem Cell Reports. 2022 Aug 1;S2213-6711(22)00364-2. doi: 10.1016/j.stemcr.2022.07.005. Online ahead of print.

Exclusive generation of rat spermatozoa in sterile mice utilizing blastocyst complementation with pluripotent stem cells

Joel Zvick, Monika Tarnowska-Sengül, Adhideb Ghosh, Nicola Bundschuh, Pjeter Gjonlleshaj, Laura C Hinte, Christine L Trautmann, Falko Noé, Xhem Qabrati, Seraina A Domenig, Inseon Kim, Thomas Hennek, Ferdinand von Meyenn, Ori Bar-Nur

Service type: goGermline™ embryos

2022

Mol Cell. 2022 Jun 16;S1097-2765(22)00540-8. doi: 10.1016/j.molcel.2022.06.004. Online ahead of print.

Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1

Samuel A Killackey, Yuntian Bi, Fraser Soares, Ikram Hammi, Nathaniel J Winsor, Ali A Abdul-Sater, Dana J Philpott, Damien Arnoult, Stephen E Girardin

Service type: Knockout mice

2022

Oncoimmunology. 2022 Jun 13;11(1):2081009. doi: 10.1080/2162402X.2022.2081009. eCollection 2022.

Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect

Kef K Prasit, Laura Ferrer-Font, Olivia K Burn, Regan J Anderson, Benjamin J Compton, Alfonso J Schmidt, Johannes U Mayer, Chun-Jen J Chen, Nathaniel Dasyam, David S Ritchie, Dale I Godfrey, Stephen R Mattarollo, P Rod Dundar, Gavin F Painter, Ian F Hermans

Service type: Transgenic mice