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2024

J Immunother Cancer. 2024 Jul 4;12(7):e008677. doi: 10.1136/jitc-2023-008677.

Impact of isotype on the mechanism of action of agonist anti-OX40 antibodies in cancer: implications for therapeutic combinations

Jane E Willoughby, Lang Dou, Sabyasachi Bhattacharya, Heather Jackson, Laura Seestaller-Wehr, David Kilian, Laura Bover, Kui S Voo, Kerry L Cox, Tom Murray, Mel John, Hong Shi, Paul Bojczuk, Junping Jing, Heather Niederer, Andrew J Shepherd, Laura Hook, Stephanie Hopley, Tatyana Inzhelevskaya, Chris A Penfold, C Ian Mockridge, Vikki English, Sara J Brett, Roopa Srinivasan, Christopher Hopson, James Smothers, Axel Hoos, Elaine Paul, Stephen L Martin, Peter J Morley, Niranjan Yanamandra, Mark S Cragg

Service type: Knock-in mice

2024

J Exp Med. 2024 Jul 1;221(7):e20231814. doi: 10.1084/jem.20231814. Epub 2024 Apr 25.

Dual fluorescence reporter mice for Ccl3 transcription, translation, and intercellular communication

Maria Belen Rodrigo, Anna De Min, Selina Kathleen Jorch, Cristina Martin-Higueras, Ann-Kathrin Baumgart, Beata Goldyn, Sara Becker, Natalio Garbi, Niels A Lemmermann, Christian Kurts

Service type: Knock-in mice

2024

Diabetes. 2024 Jun 21:db230490. doi: 10.2337/db23-0490. Online ahead of print.

Trefoil factor 2 expressed by the murine pancreatic acinar cells is required for the development of islets and for beta cell function during aging

Jose A Ortiz, Nadiah Ghazalli, Kassandra Lopez, Jeffrey Rawson, Erika M McCown, Eunjin Oh, Jose M Irimia, Kevin Jou, Jacob Mares, Min-Hsuan Chen, Xiwei Wu, Heather N Zook, Janine C Quijano, Neslihan Erdem, Anahy Lizarraga, Fouad Kandeel, Patrick T Fueger, Debbie C Thurmond, Hsun Teresa Ku

Service type: Knockout mice

2024

J Exp Med. 2024 Aug 5;221(8):e20232160. doi: 10.1084/jem.20232160. Epub 2024 Jun 6.

Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement

Zhoujie Ding, Maree Hagan, Feng Yan, Nick W Y Schroer, Jack Polmear, Kim L Good-Jacobson, Alexandra R Dvorscek, Catherine Pitt, Kristy O'Donnell, Stephen L Nutt, Dimitra Zotos, Craig McKenzie, Danika L Hill, Marcus J Robinson, Isaak Quast, Frank Koentgen, David M Tarlinton

Service type: Knockout mice

2024

Nat Commun. 2024 Jun 1;15(1):4696. doi: 10.1038/s41467-024-49066-7.

Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans

Samuel D Chauvin, Shoichiro Ando, Joe A Holley, Atsushi Sugie, Fang R Zhao, Subhajit Poddar, Rei Kato, Cathrine A Miner, Yohei Nitta, Siddharth R Krishnamurthy, Rie Saito, Yue Ning, Yuya Hatano, Sho Kitahara, Shin Koide, W Alexander Stinson, Jiayuan Fu, Nehalee Surve, Lindsay Kumble, Wei Qian, Oleksiy Polishchuk, Prabhakar S Andhey, Cindy Chiang, Guanqun Liu, Ludovic Colombeau, Raphaël Rodriguez, Nicolas Manel, Akiyoshi Kakita, Maxim N Artyomov, David C Schultz, P Toby Coates, Elisha D O Roberson, Yasmine Belkaid, Roger A Greenberg, Sara Cherry, Michaela U Gack, Tristan Hardy, Osamu Onodera, Taisuke Kato, Jonathan J Miner

Service type: Knock-in mice

2024

Clin Immunol. 2024 Jun:263:110206. doi: 10.1016/j.clim.2024.110206. Epub 2024 Apr 8.

P75NTR+CD64+ neutrophils promote sepsis-induced acute lung injury

Di Fu, Shan Gao, Jia-Nan Li, Yan-Hui Cui, Yan-Wei Luo, Yan-Jun Zhong, Qiao Li, Cong Luo, Ru-Ping Dai, Ru-Yi Luo, Zhao-Lan Hu

Service type: Knockout mice

2024

Mech Ageing Dev. 2024 May 31:220:111951. doi: 10.1016/j.mad.2024.111951.

The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop

Andreas Frøslev Mathisen, Thomas Aga Legøy, Ulrik Larsen, Lucas Unger, Shadab Abadpour, Joao A Paulo, Hanne Scholz, Luiza Ghila, Simona Chera

Service type: Knockout mice

2024

Dev Cell. 2024 May 20:S1534-5807(24)00298-3. doi: 10.1016/j.devcel.2024.04.022.

Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis

Rebecca Nightingale, Camilla M Reehorst, Natalia Vukelic, Nikolaos Papadopoulos, Yang Liao, Shalini Guleria, Caroline Bell, François Vaillant, Sudip Paul, Ian Y Luk, Amardeep S Dhillon, Laura J Jenkins, Riley J Morrow, Felicity C Jackling, Ashwini L Chand, David Chisanga, Yunshun Chen, David S Williams, Robin L Anderson, Sarah Ellis, Peter J Meikle, Wei Shi, Jane E Visvader, Bhupinder Pal, John M Mariadason

Service type: Knockout mice

2024

Endocrinology. 2024 Mar 29;165(5):bqae040. doi: 10.1210/endocr/bqae040.

Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice

Arezoo Daryadel, Cong Tang, Ye Xie, Mirko Peitzsch, Viktoria Fisi, Constanze Hantel, Dominique Loffing-Cueni, David T Breault, David Penton, Johannes Loffing, Felix Beuschlein

Service type: Knockout mice

2024

Sci Adv. 2024 Mar;10(9):eadj3551. doi: 10.1126/sciadv.adj3551. Epub 2024 Mar 1.

Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions

Adam R Wolfe, Tiantian Cui, Sooin Baie, Sergio Corrales-Guerrero, Amy Webb, Veronica Castro-Aceituno, Duan-Liang Shyu, Joanna M Karasinska, James T Topham, Daniel J Renouf, David F Schaeffer, Megan Halloran, Rebecca Packard, Ryan Robb, Wei Chen, Nicholas Denko, Michael Lisanti, Timothy C Thompson, Philippe Frank, Terence M Williams

Service type: Knockout mice

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