The ongoing Morse quest to break the code

The ongoing Morse quest to break the code

The ongoing Morse quest to break the code

In this issue

goGermline special
Latest publications
Frank’s blog
Ozgene travel
Geneoz VMS news

The ongoing Morse quest to break the code

Scientist mouseMost Virology and Cellular Immunology studies are mouse-based and use a wide range of experimental approaches to understand important biologic questions, including cellular immunology, genetic analyses, development and analysis of genetically engineered mice (conditional knockouts, knock-ins, reporters), and bioinformatics. Efforts are made to translate basic findings made in these studies to the understanding of normal human biology and diseases.

Dr. Herbert (Sandy) C. Morse III is the Chief of Virology and Cellular Immunology Section at the National Institute of Allergy and Infectious Diseases (NIAID). He has long standing interests in normal patterns of normal hematopoietic differentiation and perturbations associated with development of malignancies and autoimmunity.

One of the areas of particular interest to the Morse laboratory has been the transcription factor IRF8. These studies were facilitated by the generation of a conditional knockout of IRF8 and a “reporter” mouse expressing an IRF8-EGFP fusion protein under the control of endogenous regulatory sequences. Both are being widely distributed to interested laboratories.

Another area of interest is TRIM21 that modifies IRF8 by ubiquitylation. The protein was knocked out in mice and found to contribute to a process known as antibody-dependent intracellular neutralization of viruses.

Dr Morse is a recognized expert in the field of mouse genetics, and he serves as a member of the Committee on Standardized Genetic Nomenclature for Mice.

For more information on Dr Morse and his research, visit the NIAID website.

For further reading, see selected publications below:

  • Wang H et al. J Immunol. 2014 Aug 15.  [read]
    A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation.
  • Yoshida Y et al. Immunity. 2014 Feb 20.  [read]
    The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.
  • Chopin M et al. J Exp Med. 2013 Dec 16.  [read]
    Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks.
  • Gupta, M et al. Nat Commun, 2011 May 17.  [read]
    Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation.
  • Feng, J et al. J Immunol, 2011 Feb 1.  [read]
    IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools.
  • Atsumi, T et al. J Immunol, 2009 Jun 15.  [read]
    Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.

Scientist mouseTake advantage of goGermline special

Last month we introduced goGermline, a revolutionary technology to generate knockout and knock-in mice faster, more efficiently and with significantly fewer animals.

The first 20 projects will receive an introductory saving. Get in touch with us today to take advantage of the special!

Read more

Latest publications

Front. Cell. Neurosci. 2014 Sep 8.
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Beccano-Kelly DA, Kuhlmann N, Tatarnikov I, Volta M, Munsie LN, Chou P, Cao LP, Han H, Tapia L, Farrer MJ, Milnerwood AJ. – University of British Columbia, Canada.  [read]

Physiol Rep. 2014 Sep 4.
A Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β-cell, regeneration.
Chung CH, Miller A, Panopoulos A, Hao E, Margolis R, Terskikh A, Levine F. – Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.  [read]

Go to papers

Steve Jobs videoFrank’s blog – The Lean Ozgene story… so far

The Lean Ozgene story started as so many others, by chance. I happened to buy the book, “The Toyota Way”, by Jeff Liker during the AALAS conference…

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Ozgene travel

Frank looks forward to seeing many of you during his upcoming travels. He is also excited to present the ‘The Ozgene MindQuest’ at the ‘Operational Excellence Conference’ in Utah. In Europe, Frank will be travelling together with our European-based Principal Scientist, John Dixon.

September 2014

October 2014

  • 1: Düsseldorf, Germany
  • 2: Hannover, Germany
  • 6-7: Chicago, IL, USA
  • 8-9: Logan, UT, USA:
  • 40th Annual Operational Excellence Conference (speaker)
  • 10: Salt Lake City, UT, USA
  • 13: Seattle, WA, USA
  • 14: Portland, OR, USA
  • 15: San Francisco, CA, USA
  • 16: Los Angeles, CA, USA
  • 17: San Diego, CA, USA

If you would like to meet with Frank and John in any of these locations…

Contact us now

Einstein mouseGeneoz VMS news

Our Geneoz VMS developers pay a lot of attention to enterprise integration, making sure that any new applications integrate with existing systems. For instance, Geneoz VMS integrates with Dropbox™, myOzgene portal, Pushover™ notification application, company chat, SMSGlobal™ and the Vivarium monitoring for environmental conditions.

Go to Geneoz VMS