In this issue
As our population continues to age and life expectancies increase, so does the burden of neurodegenerative conditions such as Alzheimer’s disease. That’s why Associate Professor Elizabeth Coulson of the Queensland Brain Institute, The University of Queensland, is focusing her research on this debilitating disease.
Dr Coulson has developed a deep interest into identifying and characterising the genetic regulators of neurodegenerative disorders. Her current research specifically focuses on cell death signalling mediated by the p75 neurotrophin receptor (p75NTR) and its role in the cholinergic neurons of the brain. As part of this, she is investigating the connection between disturbed sleep and Alzheimer’s disease. The goal of the research is to use the findings to develop treatments for neurological diseases, such as Alzheimer’s. Mouse models provided by Ozgene are an important part of Dr Coulson’s research.
As an extension of her work in mouse models, Dr Coulson is developing methods to assess cholinergic degeneration by magnetic resonance imaging (MRI) and positron emission spectrography (PET). that can be translated between humans and animal models of dementia.
We hope that one day soon, Alzheimer’s will be forgotten!
For more information on Dr Coulson’s research, visit the Queensland Brain Institute website.
For more information on Ozgene mouse models, please see Ozgene services.
J Exp Med. 2014 Oct 27.
GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.
Wang X, Sumida H, Cyster JG. – University of California, San Francisco, San Francisco, CA, USA. [read]
PLoS One. 2014 Oct 13.
Ly49E Expression on CD8αα-Expressing Intestinal Intraepithelial Lymphocytes Plays No Detectable Role in the Development and Progression of Experimentally Induced Inflammatory Bowel Diseases.
Van Acker A, Filtjens J, Van Welden S, Taveirne S, Van Ammel E, Vanhees M, Devisscher L, Kerre T, Taghon T, Vandekerckhove B, Plum J, Leclercq G. – Ghent University, Ghent, Belgium. [read]
Cell Death Dis. 2014 Oct 9.
SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation.
Chaudhary N, Nakka KK, Chavali PL, Bhat J, Chatterjee S, Chattopadhyay S. – Pune University Campus, Pune & Bose Institute, Kolkata, India. [read]
Ozgene 15 years – get 15% off
We are celebrating our 15th birthday this month! To thank you for the past years, we are offering a 15% Australian Spring Special saving, and giving you 5 more reasons to start your knockout or knock-in mouse project with Ozgene!
Are you interested in the goGermline technology or the Lean management system at Ozgene, including the live timelines and live project updates? Or are you simply just curious…? Contact us today to book your personal webinar, where we show you how Ozgene works and what it means to your project.
As you may know, I have been traveling for the past two months. It was a great trip with a lot of great people. Now that I am back, business resumes as normal, hence this blog entry on an F1 tyre change…
We have now activated live project timelines through myOzgene and live project updates directly to your email. Both features are powered by Geneoz. Let us know if you would like to be among the first clients to have access to these features and provide valuable feedback for us to develop them further.