Mouse models
Mouse models
The house mouse (Mus musculus) has long been an essential mammalian model in scientific research, providing valuable insights into genetics, physiology, health, and disease. Humans and mice share many genetic and genomic similarities, making mice indispensable for understanding complex biological processes. Their small size, rapid reproduction, and ease of care make them a cost-effective and efficient research model. These combined advantages make the mouse model a powerful tool for advancing our understanding of human biology.
Generating mouse models
At Ozgene, we have an established and proven track record in generating customised mouse models for biomedical research. Our models support studies into gene function, human diseases, and the development of therapeutics. We leverage both our published and patented goGermline™ technology, and our innovative OzBIG platform, to deliver industry-leading results.
Our goGermline™ technology enables the generation of mouse models with exceptional speed, using the reliable method of gene targeting through homologous recombination. Impressively, all of our mouse model projects to date have successfully achieved germline transmission.
Complementing this, our OzBIG technology offers advanced capabilities for designing complex mouse models, including large genomic modifications, humanised models, and more sophisticated targeting strategies. This allows researchers to explore biological questions at an even deeper level, expanding the potential of mouse model research.
What technology do we use?
Ozgene specialises in generating mouse models via gene targeting in embryonic stem (ES) cells, utilising our proprietary goGermline™ technology to significantly enhance 3R (Replacement, Reduction, and Refinement) efficiencies and accelerate project timelines. We also employ our OzBIG platform for advanced and complex model generation needs.
We do not use CRISPR, as our focus remains on the proven precision and reliability of gene targeting technologies.
Customised mouse model generation
Ozgene offers customised mouse model generation where the pricing is determined by the complexity of the project, the materials provided by the customer and the desired deliverables.
We will provide an obligation free project design and proposal based on your specific requirements free of charge.
Getting started with your mouse models
Start your research sooner with Ozgene’s unbeatable mouse model generation timelines.
- We have no project queues. Ozgene’s highly efficient project pipeline allows us to start projects without lengthy waiting periods.
- Your project will start as soon as Ozgene receives a signed contract and a purchase order.
- Ozgene’s current average time for new mouse model completion is 29 weeks.
- Our fastest gene targeted mouse models have been generated in 20 weeks from project design to heterozygous targeted F1 mice.
Types of customised mouse models
We offer the following gene targeting backgrounds
- C57BL/6J
- C57BL/6N
- BALB/c
- FVB/n
- NOD
- Less common strains as required
Get in touch
We provide tailored preclinical solutions to support your research, from genetically modified mouse models to breeding and phenotyping. Request a free quote today.
Fill out the form, and our team will respond within two business days. For stock strain enquiries, contact Ozgene ARC at arc@ozgene.com. For additional contact options, visit our contact page.
“We selected Ozgene because they offered a very competitive price, published experience with similar projects, and a complete package from design to delivery with good project support throughout.“
– Dr Simon Archer, University of Surrey, UK
