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2023

Sci Rep. 2023 Mar 6;13(1):3747. doi: 10.1038/s41598-023-30663-3.

Functional dissection of two amino acid substitutions unique to the human FOXP2 protein

Ulrich Bornschein, Hugo Zeberg, Wolfgang Enard, Wulf Hevers, Svante Pääbo

Service type: Knock-in mice

2023

Nat Metab. 2023 Feb 16. doi: 10.1038/s42255-023-00736-8. Online ahead of print.

PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages

Maaike Schilperoort, David Ngai, Marina Katerelos, David A Power, Ira Tabas

Service type: Knock-in mice

2023

EMBO J. 2023 Feb 15;42(4):e112118. doi: 10.15252/embj.2022112118. Epub 2023 Jan 3.

A critical period of prehearing spontaneous Ca2+ spiking is required for hair-bundle maintenance in inner hair cells

Adam J Carlton, Jing-Yi Jeng, Fiorella C Grandi, Francesca De Faveri, Federico Ceriani, Lara De Tomasi, Anna Underhill, Stuart L Johnson, Kevin P Legan, Corné J Kros, Guy P Richardson, Mirna Mustapha, Walter Marcotti

Service type: Knock-in mice

2023

PLoS One. 2023 Feb 9;18(2):e0280792. doi: 10.1371/journal.pone.0280792. eCollection 2023.

Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney

Geoff Harley, Marina Katerelos, Kurt Gleich, Mardiana Lee, Peter F Mount, David A Power

Service type: Knock-in mice

2023

Bone. 2023 Feb;167:116636. doi: 10.1016/j.bone.2022.116636. Epub 2022 Nov 30.

Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular density

Alexandra K O'Donohue, Ya Xiao, Lucinda R Lee, Timothy Schofield, Tegan L Cheng, Craig F Munns, Paul A Baldock, Aaron Schindeler

Service type: Knockout mice

2023

mBio 2023 Jan 24;e0354222. doi: 10.1128/mbio.03542-22. Online ahead of print.

Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation

Jesse H Arbuckle, Jodi L Vogel, Stacey Efstathiou, Thomas M Kristie

Service type: Knock-in mice

2023

Sci Rep. 2023 Jan 21;13(1):1215. doi: 10.1038/s41598-023-27782-2.

Codon modification of Tuba1a alters mRNA levels and causes a severe neurodevelopmental phenotype in mice

Ines Leca, Alexander William Phillips, Lyubov Ushakova, Thomas David Cushion, David Anthony Keays

Service type: Knock-in mice

2022

Am J Physiol Endocrinol Metab 2022 Dec 1;323(6):E467-E479. doi: 10.1152/ajpendo.00401.2021. Epub 2022 Sep 21.

Genetic ablation of the preptin-coding portion of Igf2 impairs pancreatic function in female mice

E J Buckels, H-L Hsu, C M Buchanan, B G Matthews, K L Lee

Service type: Knock-in mice

2022

Curr Biol. 2022 Nov 21;32(22):4832-4841.e5. doi: 10.1016/j.cub.2022.09.037. Epub 2022 Oct 10.

Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration

Fengwei Zhang, Sarah O K Mak, Yuchu Liu, Ya Ke, Feng Rao, Wing Ho Yung, Li Zhang, Billy Kwok Chong Chow

Service type: Knockout mice

2022

J Physiol. 2022 Nov;600(22):4827-4848. doi: 10.1113/JP283811. Epub 2022 Oct 19.

Chronic reduction of store operated Ca2+ entry is viable therapeutically but is associated with cardiovascular complications

Fang Yu, Raphael Courjaret, Asha Elmi, Ethel Alcantara Adap, Nelson N Orie, Fawzi Zghyer, Satanay Hubrack, Sajad Hayat, Nidal Asaad, Stefan Worgall, Manikkam Suthanthiran, Vidya Mohamed Ali, Khaled Machaca

Service type: Knock-in mice

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