Custom model development & preclinical service
Custom engineered mouse models
Precision-targeted, rapid delivery. Powered by goGermline™ technology.
At Ozgene, we create custom mouse models to accelerate preclinical research and translational science. Whether you need a conditional knockout, knock-in, transgenic, or humanized model, our goGermline™ and OzBIG platforms deliver fast, reproducible results from concept to colony.
Why choose Ozgene
No project queues
We begin immediately upon contract and PO. Lean internal systems ensure reliable, transparent project flow.
goGermline™ technology
Patented embryo platform ensures 100% ES cell-derived germline transmission – no mosaicism, no uncertainty.
Accelerated timelines
Our lean, in-house workflows enable faster project execution without compromising quality – from targeting vector to validated live animals within ~29 weeks.
OzBIG for large genomic knock-ins
Efficiently generate large DNA insertions (20 – 240 kb), ideal for humanized models and complex targeting strategies.
In-house delivery
Design, targeting, genotyping, breeding, cryopreservation, and phenotyping, conducted in purpose-built facilities across the USA and Australia, including our AAALAC-accredited site.
What we offer
| Model type | Use case |
|---|---|
| Knockout mice | Functional gene inactivation for loss-of-function studies |
| Knock-in mice | Targeted point mutations, reporters, tags, or human gene integration |
| Conditional alleles | Tissue-specific or inducible control via Cre/Lox or FLP/FRT systems |
| Humanized models | Insert human orthologs or gene clusters to improve clinical relevance |
| Reporter Lines | Florescent/luminescent tags for in vivo tracking and imaging |
All models are generated using homologous recombination to ensure precision, reproducibility, and reliability, from simple knockouts to complex multigenic integrations.
Compare: goGermline™ vs. CRISPR
| Feature | goGermline™ (Ozgene) | CRISPR |
|---|---|---|
| Germline transmission | 100% ES cell-derived | Variable; often mosaic |
| Precision & predictability | High | May have off-target effects |
| Timeline to F1 | ~29 weeks (avg) | ~24-36 weeks (variable) |
| QC burden | Low | High (screening required) |
| Ideal for | KO, KI, humanized, conditional allele | KO, simple edits |
goGermline™ matters because it enables faster, more predictable outcomes in genetically engineered mouse model development. By ensuring 100% germline transmission from embryonic stem cells, goGermline™ streamlines the path from model creation to experimental cohorts. This reduces time, animal use, and uncertainty empowering researchers to make confident decisions, accelerate discovery, and focus on the science that matters most.
Global reach. Local precision.
With operations in Australia and the United States, Ozgene delivers genetically engineered mice to research institutes and biotech clients across North America, Europe and Asia-Pacific. All facilities meet global standards for animal ethics, compliance and biosafety.
Frequently asked questions
How long does it take to generate a custom mouse model?
Is CRISPR used in your model generation?
Do you offer phenotyping with model generation?
Can I start with just a targeting strategy?
Do you support international shipping?
Let’s build the right model for your research
Whether you’re preparing for drug discovery, grant submission or publication, Ozgene is your scientific partner in mouse model generation.
Get in touch
We provide tailored preclinical solutions to support your research, from genetically modified mouse models to breeding and phenotyping. Request a free quote today.
Fill out the form, and our team will respond within two business days. For stock strain enquiries, contact Ozgene ARC at arc@ozgene.com. For additional contact options, visit our contact page.
