All Publications Filter Results Impact of isotype on the mechanism of action of agonist anti-OX40 antibodies in cancer: implications for therapeutic combinationsDual fluorescence reporter mice for Ccl3 transcription, translation, and intercellular communicationTrefoil factor 2 expressed by the murine pancreatic acinar cells is required for the development of islets and for beta cell function during agingKi67 deficiency impedes chromatin accessibility and BCR gene rearrangementInherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humansP75NTR+CD64+ neutrophils promote sepsis-induced acute lung injuryThe age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loopEhf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesisZona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female MiceNutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditionsING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage developmentStellate cell-specific adhesion molecule protocadherin 7 regulates sinusoidal contractionDisruption of the SP-A/SP-R210L (Myo18Aα) pathway prolongs gestation and reduces fetal survival during lipopolysaccharide-induced parturition in late gestationA Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infectionInhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in miceMAPL loss dysregulates bile and liver metabolism in miceDefining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliationEfficient in vivo prime editing corrects the most frequent phenylketonuria variant, associated with high unmet medical needDivergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammationDual Tracer Test to measure tissue-specific insulin action in individual mice identifies in vivo insulin resistance without fasting hyperinsulinemiaCD98hc is a target for brain delivery of biotherapeuticsLymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networksSpecific regulation of mechanical nociception by Gβ5 involves GABA-B receptorsInhibiting membrane rupture with NINJ1 antibodies limits tissue injuryCorneal Edema in Inducible Slc4a11 Knockout Is Initiated by Mitochondrial Superoxide Induced Src Kinase ActivationThe chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liverSequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MSCo-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosisPI(4,5)P2-dependent regulation of endothelial tip cell specification contributes to angiogenesisFunctional dissection of two amino acid substitutions unique to the human FOXP2 proteinPFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophagesA critical period of prehearing spontaneous Ca2+ spiking is required for hair-bundle maintenance in inner hair cellsMutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidneyTargeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular densityDeletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral ReactivationCodon modification of Tuba1a alters mRNA levels and causes a severe neurodevelopmental phenotype in miceGenetic ablation of the preptin-coding portion of Igf2 impairs pancreatic function in female miceSecretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydrationChronic reduction of store operated Ca2+ entry is viable therapeutically but is associated with cardiovascular complicationsLong-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune responseFoxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and HypothyroidismKLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demandsDNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potentialLymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodesExclusive generation of rat spermatozoa in sterile mice utilizing blastocyst complementation with pluripotent stem cellsMitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effectHepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processingNovel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microgliaEnteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitisHobit and Blimp-1 regulate T RM abundance after LCMV infection by suppressing tissue exit pathways of T RM precursorsFunctional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in MiceIntense light elicited alveolar type 2 specific circadian PER2 protects from bacterial lung injury via BPIFB1Up-regulation of proBDNF/p75 NTR signaling in antibody-secreting cells drives systemic lupus erythematosusImmunization of mice with the self-peptide ACBP coupled to keyhole limpet hemocyaninPlatelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBACE-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC InhibitorsLoss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle TraffickingTargeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colonThe long non-coding RNA NRON promotes the development of cardiac hypertrophy in the murine heartA multifunctional mouse model to study the role of Samd3BHLHE40 promotes macrophage pro-inflammatory gene expression and functionsEndosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibitionSynthesis of human amyloid restricted to liver results in an Alzheimer disease-like neurodegenerative phenotypeGermline DDX41 mutations cause ineffective hematopoiesis and myelodysplasiaCochlear fibrocyte and osteoblast lineages expressing type 2 deiodinase identified with a Dio2 CreERt2 alleleMultifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell ProliferationMacrophage-Derived MicroRNA-21 Drives Overwhelming Glycolytic and Inflammatory Response during Sepsis via Repression of the PGE 2/IL-10 AxisComprehensive expression pattern of kin of irregular chiasm-like 3 in the adult mouse brainThe AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levelsCell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular diseaseDevelopmental and Behavioral Phenotypes in a Mouse Model of DDX3X SyndromePMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signalingMyD88 Is Not Required for Muscle Injury-Induced Endochondral Heterotopic Ossification in a Mouse Model of Fibrodysplasia Ossificans ProgressivaInducible Slc4a11 Knockout Triggers Corneal Edema Through Perturbation of Corneal Endothelial PumpHematopoietic expression of a chimeric murine-human CALR oncoprotein allows the assessment of anti-CALR antibody immunotherapies in vivoLoss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in miceInducible knockout of Clec16a in mice results in sensory neurodegenerationFgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic GluconeogenesisInhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Diseasep300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and RepairEHF is essential for epidermal and colonic epithelial homeostasis and suppresses Apc-initiated colonic tumorigenesisUsing a Reporter Mouse to Map Known and Novel Sites of GLP-1 Receptor Expression in Peripheral Tissues of Male MiceFibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse modelGeneration of an HLA-DQ2.5 Knock-In MouseThe p63 C-terminus is essential for murine oocyte integrityALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutationDefective lysosome reformation during autophagy causes skeletal muscle diseaseIntense light as anticoagulant therapy in humansAntidepressant actions of ketamine engage cell-specific translation via eIF4ERFamide-related peptide neurons modulate reproductive function and stress responsesDeletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCCA proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouseAdipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin SecretionMutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosisLong-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1-isoformsA novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cellsCharacterization of Anaphylatoxin Receptor Expression and C3a/C5a Functions in Anaphylatoxin Receptor Reporter MiceBVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for NeurodegenerationAntibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral ResponseTissue-resident memory CD8+ T cells shape local and systemic secondary T cell responsesA Self-Sustaining Endocytic-Based Loop Promotes Breast Cancer Plasticity Leading to Aggressiveness and Pro-Metastatic BehaviorAntinociceptive Effects of Potent, Selective and Brain Penetrant Muscarinic M4 Positive Allosteric Modulators in Rodent Pain ModelsDkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal GlandDefined p16 High Senescent Cell Types Are Indispensable for Mouse HealthspanPro-BDNF Knockout Causes Abnormal Motor Behaviours and Early Death in MiceIdentification of novel targets of RBM5 in the healthy and injured brain.SIRT2 Is Involved in Cisplatin-Induced Acute Kidney Injury Through Regulation of Mitogen-Activated Protein Kinase phosphatase-1Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb.Association of modulation of pro-inflammatory responses by dectin-2 with preterm delivery: An experimental model.Substitution of Murine Type I Collagen A1 3-hydroxylation Site Alters Matrix Structure but Does Not Recapitulate Osteogenesis Imperfecta Bone DysplasiaSNAP23 Depletion Enables More SNAP25/calcium Channel Excitosome Formation to Increase Insulin Exocytosis in Type 2 DiabetesDownregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation.B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2.Targeted deletion of PD-1 in myeloid cells induces antitumor immunity.Social Behaviour Is Altered in the Insulin-Regulated Aminopeptidase Knockout MouseDeficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction.Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations.Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection.Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging SuperoxideDepletion of CD40 on CD11c+ cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH.Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbsAcyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1.AMBN Mutations Causing Hypoplastic Amelogenesis Imperfecta and Ambn knockout-NLS-lacZ Knockin Mice Exhibiting Failed Amelogenesis and Ambn Tissue-SpecificityInhibitory interneurons mediate autism-associated behaviors via 4E-BP2.Heterozygous Loss of Keratinocyte TRIM16 Expression Increases Melanocytic Cell Lesions and Lymph Node MetastasisThe macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis.Altered Gut Microbiome in Parkinson’s Disease and the Influence of Lipopolysaccharide in a Human α-Synuclein Over-Expressing Mouse Model.Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium.An important role of podoplanin in hair follicle growth.Rorβ regulates selective axon-target innervation in the mammalian midbrain.The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicingGDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis.The testicular soma of Tsc22d3 knockout mice supports spermatogenesis and germline transmission from spermatogonial stem cell lines upon transplantation.Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions-Brief Report.Sacs R272C missense homozygous mice develop an ataxia phenotype.IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and CancerHobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation.Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice.Gαi2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination.Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy.Alloimmunogenicity of an isolated MHC allele is affected by the context of MHC mismatch in a murine model.Redundant and nonredundant organismal functions of EPS15 and EPS15L1.An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation.Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease.Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects.Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta.Mitochondrial complex III is essential for suppressive function of regulatory T cells.Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis.Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice.SPACIA1/SAAL1 Deletion Results in a Moderate Delay in Collagen-Induced Arthritis Activity, along with mRNA Decay of Cyclin-dependent Kinase 6 Gene.Macrophage CD40-signaling drives experimental autoimmune encephalomyelitis.Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation.Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance.Macrophagic Stabilin-1 Restored Disruption of Vascular Integrity Caused by Sepsis.CLEC16A regulates splenocyte and NK cell function in part through MEK signaling.Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis.GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation.Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice.Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction.PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice.Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses.The Parkinson’s disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mice and humans.Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans.Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling.UXT is required for spermatogenesis in mice.Rab23 Regulates Radial Migration of Projection Neurons via N-cadherinElongator subunit 3 (ELP3) modifies ALS through tRNA modification.Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis.Desacetyl-α-melanocyte-stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance.SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α.Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma.Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress.A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP DeficiencyThe tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice.Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling.Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.Drug-induced immune thrombocytopenia: Mapping of the drug binding site to the membrane-proximal region of platelet GPIX.Adipose KLF15 Controls Lipid Handling to Adapt to Nutrient Availability.Generation and phenotypic characterisation of a cytochrome P450 4×1 knockout mouse.Myeloid deficiency of CCN3 exacerbates liver injury in a mouse model of nonalcoholic fatty liver disease.Sustained T follicular helper cell response is essential for control of chronic viral infectionDichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse.Cardiovascular adaptation to hypoxia and the role of peripheral resistance.Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease.Increased liver AGEs induce hepatic injury mediated through an OST48 pathway.Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition.The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia.Monitoring C3aR Expression Using a Floxed tdTomato-C3aR Reporter Knock-in Mouse.Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration.Lineage-specific functions of TET1 in the postimplantation mouse embryo.Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging.Role of a Dual Splicing and Amino Acid Code in Myopia, Cone Dysfunction and Cone Dystrophy Associated with L/M Opsin Interchange Mutations.Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation.Endogenous inspired biomineral-installed hyaluronan nanoparticles as pH-responsive carrier of methotrexate for rheumatoid arthritis.The Inflammatory Bowel Disease-Associated Autophagy Gene Atg16L1T300A Acts as a Dominant Negative Variant in Mice.Oral prion disease pathogenesis is impeded in the specific absence of CXCR5-expressing dendritic cells.An Essential Role of Maspin in Embryogenesis and Tumor Suppression.New murine Niemann-Pick type C models bearing a pseudoexon-generating mutation recapitulate the main neurobehavioural and molecular features of the disease.α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection.Modelling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice.First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15.Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.Development and Validation of a New Mouse Model to Investigate the Role of SV2A in Epilepsy.IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniaeHumanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets.Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration.An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation.Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome.Critical Role of IL-22/IL22-RA1 Signaling in Pneumococcal Pneumonia.Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus.Inhibition of CBLB protects from lethal Candida albicans sepsis.Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.Hepatic overexpression of CD36 improves glycogen homeostasis and attenuates high-fat diet induced hepatic steatosis and insulin resistance.Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes.Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice.Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.Characterizing the molecular phenotype of an Atp7aT985I conditional knock-in mouse model for X-linked distal hereditary motor neuropathy (dHMNX).Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion.Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex.CD27 Agonism Plus PD-1 Blockade Recapitulates CD4+ T-cell Help in Therapeutic Anticancer Vaccination.The Role of Dectin-2 for Host Defense Against Disseminated CandidiasisTRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesisExclusive transmission of embryonic stem cell-derived genome through the mouse germline.Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient miceIntestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation.A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis.Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration.Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gating.Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1.Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice.Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice.Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice.Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice.Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment.Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARγ Signaling.Characterization of a genetically engineered mouse model of hemophilia A with complete deletion of the F8 gene.Helios Controls a Limited Subset of Regulatory T Cell Functions.Discovery of the imidazole-derived GPR40 agonist AM-3189.Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography.Pappa2 deletion alters IGFBPs but has little effect on glucose disposal or adiposity.Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.Response to Heard et al.Pappa2 deletion in mice affects male but not female fertility.Breeding Strategy Determines Rupture Incidence in Post-Infarct Healing WARPing Cardiovascular Research.Fam83h null mice support a neomorphic mechanism for human ADHCAICytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.PAPP-A2 expression by osteoblasts is required for normal postnatal growth in mice.Generation and characterization of mice with a conditional null allele of the HtrA4 gene.MAR binding protein SMAR1 favors IL-10 mediated regulatory T cell function in acute colitis.Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells.Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent.APP intracellular domain-WAVE1 pathway reduces amyloid-β production.Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury.The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.Age-related hearing loss and degeneration of cochlear hair cells in mice lacking thyroid hormone receptor β1.The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 RestorationDifferential Tissue-Specific Function of Adora2b in Cardioprotection.Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD).Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice.Inductively coupled mass spectrometry analysis of biometals in conditional Hamp1 and Hamp1 and Hamp2 transgenic mouse models.Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus.Anti-PCSK9 Antibody Pharmacokinetics and Low-Density Lipoprotein-Cholesterol Pharmacodynamics in Nonhuman Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to Neonatal Fc Receptor-Binding Enhancement.Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.Epithelial NAIPs protect against colonic tumorigenesis.Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease.Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse.The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1.Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development.Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain.Positron emission tomography and functional characterization of a complete PBR/TSPO knockout.Nox2 Knockout Delays Infarct Progression and Increases Vascular Recovery through Angiogenesis in Mice following Ischaemic Stroke with Reperfusion.GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.Ly49E Expression on CD8αα-Expressing Intestinal Intraepithelial Lymphocytes Plays No Detectable Role in the Development and Progression of Experimentally Induced Inflammatory Bowel Diseases.SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation.12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance.PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol and atherosclerosis in the absence of ApoE.The Role of p75NTR in Cholinergic Basal Forebrain Structure and Function.Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in miceMaternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β-cell, regeneration.A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell DifferentiationRunx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer.Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland.Netrin-1 controls sympathetic arterial innervation.The diabetes susceptibility gene clec16a regulates mitophagy.AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndrome.Facilitation of endoglin-targeting cancer therapy by development/utilization of a novel genetically engineered mouse model expressing humanized endoglin (CD105).Characterization of the Mitofusin 2 R94W Mutation in a Knock-in Mouse Model.Stress- and diet-induced fat gain is controlled by NPY in catecholaminergic neuronsOptimization of GPR40 Agonists for Type 2 DiabetesNaive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells.Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells.The co-repressor Rcor1 is essential for murine erythropoiesis.Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy.A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism.Physiological expression of the PI3K-activating mutation Pik3caH1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation.Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages.Transforming Growth Factor β-induced Protein Promotes Severe Vascular Inflammatory Responses.S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variantp85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression.Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages.Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection.Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks.The role of Dectin-2 for host defense against systemic infection with Candida glabrata.Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation.Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.KLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells.Normal Autophagic Activity in Macrophages from Mice Lacking Gαi3, AGS3, or RGS19.Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice.Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases.Regulation of stress-inducible phosphoprotein 1 nuclear retention by protein inhibitor of activated STAT PIAS1.Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality.Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression.Development of a Conditional Mesd (Mesoderm Development) Allele for Functional Analysis of the Low-Density Lipoprotein Receptor-Related Family in Defined TissuesInositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction.Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy.Lrig2-deficient mice are protected against PDGFB-induced glioma.Kruppel-like factor 15 is critical for vascular inflammation.The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice.Loss of the Nuclear Receptor Corepressor SLIRP Compromises Male Fertility.Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury.Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injuryIMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts.Loss of Usp9x Disrupts Cortical Architecture, Hippocampal Development and TGFβ-Mediated Axonogenesis.Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4.Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells.Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein.Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils.Glucose homeostasis in mice is transglutaminase 2 independent.Signaling of high mobility group box 1 (HMGB1) through toll-like receptor 4 in macrophages requires CD14.Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation.Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering.Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type-Specific Functions of TLR4 during Sepsis.Rgs13 constrains early B cell responses and limits germinal center sizes.Cellular specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury.Nitroxyl (HNO) Suppresses Vascular Nox2 Oxidase Activity.TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator.Dexras1, a Small GTPase, Is Required for Glutamate-NMDA Neurotoxicity.Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.Pregnancy Associated Plasma Protein A2 (PAPP-A2) Affects Bone Size and Shape and Contributes to Natural Variation in Postnatal Growth in Mice.Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2.Divergent effects of endogenous and exogenous GILZ in models of inflammation and arthritis.Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo.Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet.NLRX1 does not inhibit MAVS-dependent antiviral signalling.Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genesGeneration of mice with a conditional null Fraser syndrome 1 (Fras1) allele.Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase.Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis.Elimination of Germinal Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen.A phenotype survey of thirty-six mutant mouse strains with gene targeted defects in glycosyltransferases or glycan-binding proteins.Genetic Deletion of RALA and RALB Small GTPases Reveals Redundant Functions in Development and Tumorigenesis.A2B Adenosine Receptor Expression by Myeloid Cells Is Proinflammatory in Murine Allergic-Airway Inflammation.Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion.Intestinal epithelial toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype.Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling.Redd1 Is a Novel Marker of Testis Development but Is Not Required for Normal Male Reproduction.Role of STAT1 in the breast.Mice Deficient in GEM GTPase Show Abnormal Glucose Homeostasis Due to Defects in Beta-Cell Calcium Handling.Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria.Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6.Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a responseMethionine sulfoxide reductase contributes to meeting dietary methionine requirements.PORCN Moonlights in a Wnt-Independent Pathway That Regulates Cancer Cell Proliferation.Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice.Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo.NLRC5 deficiency selectively impairs MHC class I-dependent lymphocyte killing by cytotoxic T cells.IAPs limit activation of RIP kinases by TNF receptor 1 during development.Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice.Alcohol and aldehyde dehydrogenases: Retinoid metabolic effects in mouse knockout models.Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype.Microenvironmental regulation by fibrillin-1.An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.Regulation of the probability of mouse odorant receptor gene choice.Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures.Analgesic Tolerance to High-Efficacy Agonists But Not to Morphine Is Diminished in Phosphorylation-Deficient S375A {micro}-Opioid Receptor Knock-In Mice.Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat FormationProduction of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity StudiesAMP-activated protein kinase (AMPK) {beta}1{beta}2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.Preclinical development of CAT-354, an IL-13-neutralising antibody, for the treatment of severe uncontrolled asthma.Lung-specific loss of the laminin {alpha}3 subunit confers resistance to mechanical injuryPIKE-mediated PI3-kinase activity is required for AMPA receptor surface expressionTwo transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations.Human Cancer-Associated Mutations in A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-in and Knockout Mice.Central nervous system dysfunction in a mouse model of FA2H deficiency.Evidence That Cd101 Is an Autoimmune Diabetes Gene in Nonobese Diabetic Mice.Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex.Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation.Exploring phospholipase C-coupled Ca(2+) signalling networks using boolean modelling.Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.Adenosine Negative Feedback On A2A Adenosine Receptors Mediates Hypo-Responsiveness In Chronically Septic MiceCrucial role of alkaline sphingomyelinase in sphingomyelin digestion: A study on the enzyme knockout mice.piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid SignalingThe phosphoinositide kinase PIKfyve is vital in early embryonic development: Preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- miceDeletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center responseIFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools.Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase.Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKBA2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice.Vstm3 is a Member of the CD28 Family and an Important Modulator of T Cell FunctionGroup V secretory phospholipase A2 plays a pathogenic role in myocardial ischaemia-reperfusion injury.Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.A comparative study of Lrrk2 function in primary neuronal cultures.Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK.Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise CapacitymicroRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus.The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas.Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells.Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activityThe SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.Regional neural tube closure defined by the Grainy head-like transcription factors.Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation.PNPASE regulates RNA import into mitochondria.In vivo studies of mutant fibrillin-1 microfibrils.Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus.S100A4 regulates macrophage chemotaxisAGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice.Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene, BORISc-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia.Expression of helios, an ikaros transcription factor family member, differentiates thymic-derived from peripherally induced foxp3+ T regulatory cells.PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland developmentGermline deletion of AMP-activated protein kinase {beta} subunits reduces bone mass without altering osteoclast differentiation or function.Death-associated protein kinase-mediated cell death modulated by interaction with DANGEREngineering the mouse genome to model human disease for drug discovery.Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- miceAcute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.Toll-like-receptor-4 Inhibits Enterocyte Proliferation via Impaired beta-catenin Signaling in Necrotizing Enterocolitis.Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory.Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice.Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses.Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice.A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in MiceGene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.Probasin Promoter Driven Expression of ID1 Is not Sufficient for Carcinogenesis in Rodent Prostate.Mice lacking the extracellular matrix protein WARP develop normally but have compromised peripheral nerve structure and function.Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel co-localized with mGluR6 at mouse photoreceptor ribbon synapses.Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.Testis Development, Fertility, and Survival in Ethanolamine Kinase 2-Deficient Mice.Osteoclast inhibitory lectin (OCIL), an immune cell product that is required for normal bone physiology in vivo.ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein.Rat aquaporin-5 4.3-Kb 5′-flanking region differentially regulates expression in salivary gland and lung in vivo.Conditional activation of a single-copy L1 transgene in mice by Cre.The extracellular matrix protein WARP is a novel component of a distinct subset of basement membranes.The murine stanniocalcin 2 gene is a negative regulator of post-natal growth.Enamel Defects and Ameloblast-specific Expression in Enam Knock-out/lacZ Knock-in Mice.Distal cis-regulatory elements are required for tissue-specific expression of enamelin (Enam).Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1.The Ets transcription factor Elf5 specifies mammary alveolar cell fate.Perturbed desmosomal cadherin expression in grainy head-like 1-null mice.Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis.An important role for type III Interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity.Anoikis effector Bit1 negatively regulates Erk activity.The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells.Sequences in intron 51 of the von Willebrand factor gene target promoter activation to a subset of lung endothelial cells in transgenic mice.IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosisNOTCH1 pathway activation is an early hallmark of SCL T-leukemogenesis.Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair.Temporal regulation of Cre-recombinase activity in Scl-positive neurons of the central nervous system.Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro.Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action.The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent.Renin enhancer is critical for control of renin gene expression and cardiovascular function.Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodiesEndoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis.Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination.Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development.Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterningGout-associated uric acid crystals activate the NALP3 inflammasome.The murine stanniocalcin 1 gene is not essential for growth and development.Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.Generation of transgenic mice with mild and severe retinal neovascularisation.Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptationA homolog of Drosophila grainy head is essential for epidermal integrity in mice.In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis.Lentiviral vector-based models of amyloid pathology: from cells to animals.Matrix Metalloproteinases Are Not Essential for Aggrecan Turnover during Normal Skeletal Growth and Development.Human growth hormone presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejection.Genetically tagging endothelial cells in vivo: bone marrow derived cells do not contribute toal Growth and Development.The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removalEdd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion.Novel approaches to models of Alzheimer’s disease pathology for drug screening and development.The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5′ bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain.Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice.Role of the polymeric Ig receptor in mucosal B cell homeostasis.The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU S12.Impaired cardiac contractility response to hemodynamic stress in S100A1 deficient mice.FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses.A 320 kilobase artificial chromosome encoding the human HLA DR3 DQ2 MHC haplotype confers HLA restriction in transgenic mice.Essential role for the lymphostromal plasma membrane Ly 6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland.Efficient Cre mediated deletion in cardiac progenitor cells conferred by a 3’UTR ires Cre allele of the homeobox gene Nkx2 5.Molecular cloning of F4/80 like receptor, a seven span membrane protein expressed differentially by dendritic cell and monocyte macrophage subpopulations.The small muscle specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin like growth factor 1 dependent manner.Impaired thrombin generation in beta 2-glycoprotein I null mice.Gene targeting in a centralized facility.Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2 5.Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.Gigantism in mice lacking suppressor of cytokine signalling 2.Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis.Proapoptotic Bcl 2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.A direct method for the formation of peptide and carbohydrate dendrimers.Apoptosis regulator bcl w is essential for spermatogenesis but appears otherwise redundant.EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract.Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ “knock in” strategyMajor histocompatibility complex class II expression by intrinsic renal cells is required for crescentic glomerulonephritis.Induction of acute inflammation in vivo by staphylococcal superantigens I: Leukocyte recruitment occurs independently of T lymphocytes and major histocompatibility complex Class II molecules.Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation.Distinct roles for lymphotoxin alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue.Adult mice with targeted mutation of the interleukin 11 receptor (IL11Ra) display normal hematopoiesis.The role of leukemia inhibitory factor in skeletal muscle regeneration.Homeosis and intestinal tumours in Cdx2 mutant mice.The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.Resistance to endotoxin shock and reduced dissemination of gram negative bacteria in CD14 deficient mice.Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte macrophage colony stimulating factor and interleukins 3 and 5.Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expressionAbsence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.Creation and characterization of E selectin and VCAM 1 deficient mice.Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins.T cell development in mice lacking the CD3 zeta/eta gene.Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF mediated toxicity but highly susceptible to infection by Listeria monocytogenes.Targeted disruption of the MHC class II Aa gene in C57BL/6 mice.Simple screening procedure to detect gene targeting events in embryonic stem cells.Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor.
